CHEBI:15611

Three steps

• 4-methyl-2-oxopentanoateReach from here →
  1. sarcosine:oxygen oxidoreductase (demethylating)
  2. transport of glycine and leucine (cytosol to extracellular)
  3. L-Leucine:2-oxoglutarate aminotransferase

  Catalysed by PIPOX, SARDH, SLC7A5, BCAT2peroxisome, extracellular space, cytosol, mitochondrial matrixOne of 5 routes

• CHEBI:17927Reach from here →
  1. sarcosine:oxygen oxidoreductase (demethylating)
  2. bile acid-CoA: amino acid N-acyltransferase
  3. N1,N8-diacetylspermidine to N1-acetylspermidine conversion

  Catalysed by PIPOX, SARDH, BAATperoxisome, cytosolOne of 2 routes

• 3-phenylpyruvateReach from here →
  1. sarcosine:oxygen oxidoreductase (demethylating)
  2. transport of glycine and phenylalanine (cytosol to extracellular)
  3. Phenylalanine Transaminase, Mitochondrial

  Catalysed by PIPOX, SARDH, SLC7A5, GOT2 and 1 moreperoxisome, extracellular space, cytosol, mitochondrial matrixOne of 6 routes

• dTDPReach from here →
  1. sarcosine dehydrogenase (sarcosine)
  2. 5,10-Methylenetetrahydrofolate:dUMP C-methyltransferase
  3. DTDP Diphosphohydrolase

  Catalysed by SARDH, TYMS, ENTPD3, ENTPD1 and 1 moremitochondrial matrix, cytosol, extracellular spaceOne of 6 routes

• dTTPReach from here →
  1. sarcosine dehydrogenase (sarcosine)
  2. 5,10-Methylenetetrahydrofolate:dUMP C-methyltransferase
  3. dTTP + H2O = dTMP + diphosphate + H(+)

  Catalysed by SARDH, TYMS, ASMTLmitochondrial matrix, cytosol

• CHEBI:18095Reach from here →
  1. sarcosine:oxygen oxidoreductase (demethylating)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)

  Catalysed by PIPOX, SARDH, SLC6A9, SLC6A14 and 2 moreperoxisome, extracellular space, cytosolOne of 5 routes

• N-carbamoyl-beta-alanineReach from here →
  1. sarcosine:oxygen oxidoreductase (demethylating)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. Transport of 3-Ureidopropionate

  Catalysed by PIPOX, SARDH, SLC6A9, SLC6A14peroxisome, extracellular space, cytosolOne of 2 routes

• N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamideReach from here →
  1. sarcosine:oxygen oxidoreductase (demethylating)
  2. 5-Phospho-D-ribosylamine:glycine ligase (ADP-forming)
  3. 10-formyltetrahydrofolate:5'-phosphoribosylglycinamide formyltransferase

  Catalysed by PIPOX, SARDH, GARTperoxisome, cytosol

• arsenic triglutathioneReach from here →
  1. sarcosine:oxygen oxidoreductase (demethylating)
  2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
  3. arsenic triglutathione + 3 [thioredoxin]-dithiol + 3 S-adenosyl-L-methionine = trimethylarsine + 3 [thioredoxin]-disulfide + 3 glutathione + 3 S-adenosyl-L-homocysteine + 3 H(+)

  Catalysed by PIPOX, SARDH, GSS, AS3MTperoxisomeOne of 3 routes

• 2-phenylethylamineReach from here →
  1. sarcosine:oxygen oxidoreductase (demethylating)
  2. transport of glycine and phenylalanine (cytosol to extracellular)
  3. L-phenylalanine carboxy-lyase (phenylethylamine-forming)

  Catalysed by PIPOX, SARDH, SLC7A5, DDCperoxisome, extracellular space, cytosol

• 2-formamido-N(1)-(5-phospho-D-ribosyl)acetamidineReach from here →
  1. sarcosine:oxygen oxidoreductase (demethylating)
  2. transport of glutamine and glycine (cytosol to extracellular)
  3. 5'-Phosphoribosylformylglycinamide:L-glutamine amido-ligase (ADP-forming)

  Catalysed by PIPOX, SARDH, SLC7A5, PFASperoxisome, extracellular space, cytosol

• gamma-L-glutamyl-(2S)-2-aminobutanoateReach from here →
  1. sarcosine:oxygen oxidoreductase (demethylating)
  2. (2S)-2-aminobutanoate + glyoxylate = 2-oxobutanoate + glycine
  3. (2S)-2-aminobutanoate + L-glutamate + ATP = gamma-L-glutamyl-(2S)-2-aminobutanoate + ADP + phosphate + H(+)

  Catalysed by PIPOX, SARDH, AGXT2, GCLCperoxisome

• S-methylmercury-L-cysteineReach from here →
  1. sarcosine:oxygen oxidoreductase (demethylating)
  2. transport of glycine and methionine (cytosol to extracellular)
  3. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)

  Catalysed by PIPOX, SARDH, SLC7A5, SLC7A8peroxisome, extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 6 routes

• 2-aminoisobutanoateReach from here →
  1. sarcosine:oxygen oxidoreductase (demethylating)
  2. transport of alanine and glycine (cytosol to extracellular)
  3. 2-aminoisobutanoate(out) + L-alanine(in) = 2-aminoisobutanoate(in) + L-alanine(out)

  Catalysed by PIPOX, SARDH, SLC3A2, SLC7A5 and 1 moreperoxisome, extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• 15-deoxy-Delta(12,14)-prostaglandin J2-S-(R)-glutathioneReach from here →
  1. sarcosine:oxygen oxidoreductase (demethylating)
  2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
  3. 15-deoxy-Delta(12,14)-prostaglandin J2 + glutathione = 15-deoxy-Delta(12,14)-prostaglandin J2-S-(R)-glutathione

  Catalysed by PIPOX, SARDH, GSS, MGST3peroxisome

• (6R)-10-formyltetrahydrofolateReach from here →
  1. sarcosine:oxygen oxidoreductase (demethylating)
  2. formaldehyde + NAD(+) + H2O = formate + NADH + 2 H(+)
  3. (6S)-5,6,7,8-tetrahydrofolate + formate + ATP = (6R)-10-formyltetrahydrofolate + ADP + phosphate

  Catalysed by PIPOX, SARDH, ALDH9A1, MTHFD1 and 1 moreperoxisomeOne of 3 routes

• (5S)-hydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoateReach from here →
  1. sarcosine:oxygen oxidoreductase (demethylating)
  2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
  3. (5S)-hydroperoxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O

  Catalysed by PIPOX, SARDH, GSS, GPX1 and 1 moreperoxisome

• (12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoateReach from here →
  1. sarcosine:oxygen oxidoreductase (demethylating)
  2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
  3. (12S)-hydroperoxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O

  Catalysed by PIPOX, SARDH, GSS, GPX1 and 1 moreperoxisome

• (15S)-hydroxy-(11Z,13E)-eicosadienoateReach from here →
  1. sarcosine:oxygen oxidoreductase (demethylating)
  2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
  3. (15S)-hydroperoxy-(11Z,13E)-eicosadienoate + 2 glutathione = (15S)-hydroxy-(11Z,13E)-eicosadienoate + glutathione disulfide + H2O

  Catalysed by PIPOX, SARDH, GSS, GPX1 and 1 moreperoxisome

• (17S)-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoateReach from here →
  1. sarcosine:oxygen oxidoreductase (demethylating)
  2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
  3. (17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + 2 glutathione = (17S)-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + glutathione disulfide + H2O

  Catalysed by PIPOX, SARDH, GSS, GPX1 and 1 moreperoxisome

• a hydroxy-1,2-diacyl-glycero-3-phosphocholineReach from here →
  1. sarcosine:oxygen oxidoreductase (demethylating)
  2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
  3. a hydroperoxy-1,2-diacyl-glycero-3-phosphocholine + 2 glutathione = a hydroxy-1,2-diacyl-glycero-3-phosphocholine + glutathione disulfide + H2O

  Catalysed by PIPOX, SARDH, GSS, GPX4peroxisome

• glycodeoxycholate 3-sulfateReach from here →
  1. sarcosine:oxygen oxidoreductase (demethylating)
  2. Glycodeoxycholate amidohydrolase
  3. glycodeoxycholate + 3'-phosphoadenylyl sulfate = glycodeoxycholate 3-sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by PIPOX, SARDH, SULT2A1peroxisome, cytosol

• 5-(3,3-dimethylguanidino)-2-oxopentanoateReach from here →
  1. sarcosine:oxygen oxidoreductase (demethylating)
  2. glycine + 2-oxoglutarate = glyoxylate + L-glutamate
  3. N(omega),N(omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + glycine

  Catalysed by PIPOX, SARDH, AADAT, AGXT2peroxisomeOne of 7 routes

• 5-(3,3'-dimethylguanidino)-2-oxopentanoateReach from here →
  1. sarcosine:oxygen oxidoreductase (demethylating)
  2. glycine + 2-oxoglutarate = glyoxylate + L-glutamate
  3. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine

  Catalysed by PIPOX, SARDH, AADAT, AGXT2peroxisomeOne of 3 routes

• 5-(3-methylguanidino)-2-oxopentanoateReach from here →
  1. sarcosine:oxygen oxidoreductase (demethylating)
  2. glycine + 2-oxoglutarate = glyoxylate + L-glutamate
  3. N(omega)-methyl-L-arginine + glyoxylate = 5-(3-methylguanidino)-2-oxopentanoate + glycine

  Catalysed by PIPOX, SARDH, AADAT, AGXT2peroxisomeOne of 3 routes

• S-disulfanyl-L-cysteineReach from here →
  1. sarcosine:oxygen oxidoreductase (demethylating)
  2. transport of cysteine and glycine (cytosol to extracellular)
  3. S-sulfanyl-L-cysteine + L-cysteine = S-disulfanyl-L-cysteine + L-alanine

  Catalysed by PIPOX, SARDH, SLC3A2, SLC7A5 and 2 moreperoxisome, extracellular space, cytosol

• (5Z)-dodecenoyl-CoAReach from here →
  1. sarcosine:oxygen oxidoreductase (demethylating)
  2. bile acid-CoA: amino acid N-acyltransferase
  3. acetyl-CoA C-acyltransferase (3-oxomyrist-7-enoyl-CoA)

  Catalysed by PIPOX, SARDH, BAAT, HADHA and 2 moreperoxisome, mitochondrial matrixOne of 2 routes

• (11Z)-docosenoyl-CoA(4-)Reach from here →
  1. sarcosine:oxygen oxidoreductase (demethylating)
  2. bile acid-CoA: amino acid N-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (cis-cetoleic acid)

  Catalysed by PIPOX, SARDH, BAAT, SLC27A2 and 7 moreperoxisome, cytosolOne of 5 routes

• (7Z)-tetradecenoyl-CoAReach from here →
  1. sarcosine:oxygen oxidoreductase (demethylating)
  2. bile acid-CoA: amino acid N-acyltransferase
  3. long-chain-fatty-acid-CoA ligase ((7Z)-tetradecenoic acid)

  Catalysed by PIPOX, SARDH, BAAT, SLC27A2 and 7 moreperoxisome, cytosolOne of 8 routes

• (4Z,7Z,10Z,13Z)-hexadecatetraenoyl-CoAReach from here →
  1. sarcosine:oxygen oxidoreductase (demethylating)
  2. bile acid-CoA: amino acid N-acyltransferase
  3. Fatty Acid Beta Oxidation (C18:4->C16:4), Mitochondrial

  Catalysed by PIPOX, SARDH, BAAT, HADHA and 2 moreperoxisome, mitochondrial matrixOne of 3 routes

• (7Z,10Z)-hexadecadienoyl-CoAReach from here →
  1. sarcosine:oxygen oxidoreductase (demethylating)
  2. bile acid-CoA: amino acid N-acyltransferase
  3. Fatty Acid Beta Oxidation Trans (C18:2->C16:2), Mitochondrial

  Catalysed by PIPOX, SARDH, BAAT, HADHA and 2 moreperoxisome, mitochondrial matrix

• (4Z,7Z)-decadienoyl-CoAReach from here →
  1. sarcosine:oxygen oxidoreductase (demethylating)
  2. bile acid-CoA: amino acid N-acyltransferase
  3. Fatty Acid Beta Oxidation (C12:3->C10:2), Mitochondrial

  Catalysed by PIPOX, SARDH, BAAT, ECHS1 and 2 moreperoxisome, mitochondrial matrixOne of 2 routes

• (5Z)-octenoyl-CoAReach from here →
  1. sarcosine:oxygen oxidoreductase (demethylating)
  2. bile acid-CoA: amino acid N-acyltransferase
  3. Fatty Acid Beta Oxidation (C10:2->C8:1), Mitochondrial

  Catalysed by PIPOX, SARDH, BAAT, ECHS1 and 2 moreperoxisome, mitochondrial matrixOne of 2 routes

• 3-(glutathion-S-yl)-4-hydroxynonanalReach from here →
  1. sarcosine:oxygen oxidoreductase (demethylating)
  2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
  3. (E)-4-hydroxynon-2-enal + glutathione = 3-(glutathion-S-yl)-4-hydroxynonanal

  Catalysed by PIPOX, SARDH, GSS, GSTP1peroxisome

• glycoursodeoxycholate 3-sulfateReach from here →
  1. sarcosine:oxygen oxidoreductase (demethylating)
  2. glycine to glycoursodeoxycholate conversion
  3. glycoursodeoxycholate + 3'-phosphoadenylyl sulfate = glycoursodeoxycholate 3-sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by PIPOX, SARDH, SULT2A1peroxisome, cytosol

• glycochenodeoxycholate 3-sulfateReach from here →
  1. sarcosine:oxygen oxidoreductase (demethylating)
  2. chenodeoxycholoyl-CoA + glycine = glycochenodeoxycholate + CoA + H(+)
  3. glycochenodeoxycholate + 3'-phosphoadenylyl sulfate = glycochenodeoxycholate 3-sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by PIPOX, SARDH, BAAT, SULT2A1peroxisome

• deoxycholateReach from here →
  1. sarcosine:oxygen oxidoreductase (demethylating)
  2. Glycodeoxycholate amidohydrolase
  3. Glycodeoxycholate amidohydrolase

  Catalysed by PIPOX, SARDHperoxisome, cytosol

• a quinolReach from here →
  1. sarcosine:oxygen oxidoreductase (demethylating)
  2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
  3. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol

  Catalysed by PIPOX, SARDH, GSS, SQORperoxisome

• hypochlorous acidReach from here →
  1. sarcosine:oxygen oxidoreductase (demethylating)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. Peroxidase

  Catalysed by PIPOX, SARDH, SLC6A9, SLC6A14 and 1 moreperoxisome, extracellular space, cytosolOne of 4 routes

• potassium atomReach from here →
  1. sarcosine:oxygen oxidoreductase (demethylating)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. transport of chloride (cytosol to extracellular)

  Catalysed by PIPOX, SARDH, SLC6A9, SLC6A14 and 2 moreperoxisome, extracellular space, cytosolOne of 2 routes

• folic acidReach from here →
  1. sarcosine dehydrogenase (sarcosine)
  2. 5,10-Methylenetetrahydrofolate:dUMP C-methyltransferase
  3. dihydrofolate:NAD+ oxidoreductase

  Catalysed by SARDH, TYMS, DHFR, DHFR2mitochondrial matrix, cytosolOne of 2 routes

• CHEBI:27540Reach from here →
  1. sarcosine:oxygen oxidoreductase (demethylating)
  2. bile acid-CoA: amino acid N-acyltransferase
  3. medium-chain acyl-CoA ligase (hexanoic acid)

  Catalysed by PIPOX, SARDH, BAAT, ACSM4 and 5 moreperoxisome, cytosolOne of 6 routes

• selenomethionineReach from here →
  1. sarcosine dehydrogenase (sarcosine)
  2. 5-methyltetrahydrofolate:NADP+ oxidoreductase
  3. Methionine Synthase

  Catalysed by SARDH, MTHFRmitochondrial matrix, cytosol, nucleusOne of 2 routes

• elaidic acidReach from here →
  1. sarcosine:oxygen oxidoreductase (demethylating)
  2. bile acid-CoA: amino acid N-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (elaidate)

  Catalysed by PIPOX, SARDH, BAAT, SLC27A2 and 7 moreperoxisome, cytosolOne of 5 routes

• 5-hydroxytryptophanReach from here →
  1. sarcosine:oxygen oxidoreductase (demethylating)
  2. transport of glycine and tryptophan (cytosol to extracellular)
  3. L-Tryptophan, Tetrahydrobiopterin:Oxygen Oxidoreductase (5-Hydroxylating)

  Catalysed by PIPOX, SARDH, SLC7A5, TPH1 and 1 moreperoxisome, extracellular space, cytosolOne of 2 routes

• 5(S)-HETEReach from here →
  1. sarcosine:oxygen oxidoreductase (demethylating)
  2. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
  3. Glutathione: 5-HPETE oxidoreductase

  Catalysed by PIPOX, SARDH, GSS, GPX5 and 8 moreperoxisome, cytosolOne of 2 routes

• CHEBI:28701Reach from here →
  1. sarcosine:oxygen oxidoreductase (demethylating)
  2. bile acid-CoA: amino acid N-acyltransferase
  3. Propanoyl-CoA:acetyl-CoA C-acyltransferase

  Catalysed by PIPOX, SARDH, BAAT, ACAA1 and 2 moreperoxisomeOne of 7 routes

• pyridoxine 5'-phosphateReach from here →
  1. sarcosine:oxygen oxidoreductase (demethylating)
  2. transport of alanine and glycine (cytosol to extracellular)
  3. L-selenocysteine selenide-lyase (L-alanine-forming)

  Catalysed by PIPOX, SARDH, SLC3A2, SLC7A5 and 2 moreperoxisome, extracellular space, cytosol

• N-acetyl-L-cysteineReach from here →
  1. sarcosine:oxygen oxidoreductase (demethylating)
  2. transport of cysteine and glycine (cytosol to extracellular)
  3. N-acetylglutamate synthase (N-acetyl-L-cysteine)

  Catalysed by PIPOX, SARDH, SLC3A2, SLC7A5 and 2 moreperoxisome, extracellular space, cytosol, mitochondrial matrix

• a dicarboxylateReach from here →
  1. sarcosine:oxygen oxidoreductase (demethylating)
  2. Hippurate (Benzoylglycinate) Formation
  3. N-benzoylglycine(out) + a dicarboxylate(in) = N-benzoylglycine(in) + a dicarboxylate(out)

  Catalysed by PIPOX, SARDH, SLC22A6, SLC22A8peroxisome, mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes