propionyl-CoA

Two steps

• chlorine(.)Reach from here →
  1. Active Transport
  2. Carnitine Transport by Atb0

  Catalysed by SLC6A14mitochondrial matrix, cytosol, extracellular space

• acetateReach from here →
  1. Propanoyl-CoA hydrolase
  2. transport of acetate and propanoate (cytosol to extracellular)

  Catalysed by ACOT7, SLC16A4, SLC16A5, SLC16A7 and 1 morecytosol, extracellular spaceOne of 2 routes

• formic acidReach from here →
  1. Propanoyl-CoA hydrolase
  2. transport of formate and propanoate (cytosol to extracellular)

  Catalysed by ACOT7, SLC16A4, SLC16A5, SLC16A1cytosol, extracellular spaceOne of 2 routes

• butyric acidReach from here →
  1. Propanoyl-CoA hydrolase
  2. transport of butyrate and propanoate (cytosol to extracellular)

  Catalysed by ACOT7, SLC16A4, SLC16A5, SLC16A7 and 1 morecytosol, extracellular spaceOne of 2 routes

• (9Z)-octadecenoateReach from here →
  1. Active Transport
  2. Utilized Transport

  No catalyst recordedmitochondrial matrix, cytosol, endoplasmic reticulumOne of 2 routes

• (9Z)-hexadecenoateReach from here →
  1. Active Transport
  2. Utilized Transport

  No catalyst recordedmitochondrial matrix, cytosol, endoplasmic reticulumOne of 6 routes

• (5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. Active Transport
  2. Utilized Transport

  No catalyst recordedmitochondrial matrix, cytosol, endoplasmic reticulumOne of 2 routes

• (S)-lactic acidReach from here →
  1. Propanoyl-CoA hydrolase
  2. transport of L-lactate and propanoate (cytosol to extracellular)

  Catalysed by ACOT7, SLC16A4, SLC16A5, SLC16A3 and 3 morecytosol, extracellular spaceOne of 2 routes

• taurineReach from here →
  1. Propanoyl-CoA hydrolase
  2. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)

  Catalysed by ACOT7, BAATcytosolOne of 2 routes

• glycineReach from here →
  1. Propanoyl-CoA hydrolase
  2. glycine N-acyltransferase (N-arachidonoylglycine)

  Catalysed by ACOT7, GLYAT, GLYATL2, GLYATL1cytosol, mitochondrial matrixOne of 10 routes

• (R)-methylmalonyl-CoAReach from here →
  1. Propanoyl-CoA hydrolase
  2. aldehyde dehydrogenase (2-methyl-3-oxopropanoate)

  Catalysed by ACOT7, ALDH6A1cytosol, mitochondrial matrixOne of 4 routes

• 3'-dephospho-CoAReach from here →
  1. Propanoyl-CoA hydrolase
  2. acid phosphatase 2, lysosomal (CoA)

  Catalysed by ACOT7, ACP2cytosol, lysosomeOne of 2 routes

• (2E)-dodecenoyl-CoAReach from here →
  1. Propanoyl-CoA hydrolase
  2. (2E)-dodecenoyl-CoA formation

  Catalysed by ACOT7cytosol, mitochondrial matrixOne of 3 routes

• 4,8,12-trimethyltridecanoyl-CoAReach from here →
  1. Propanoyl-CoA hydrolase
  2. propanoyl-CoA C-acyltransferase (3-ketopristanoyl-CoA)

  Catalysed by ACOT7, ACAA1, MYO5Bcytosol, peroxisomeOne of 2 routes

• (6Z,9Z,12Z)-octadecatrienoyl-CoAReach from here →
  1. Propanoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (gamma-linolenate)

  Catalysed by ACOT7, SLC27A2, ACSL4, ACSL3 and 5 morecytosolOne of 7 routes

• butanoyl-CoAReach from here →
  1. Propanoyl-CoA hydrolase
  2. Butanoate:CoA ligase (AMP-forming)

  Catalysed by ACOT7, ACSM4, ACSM1, ACSM2A and 3 morecytosolOne of 11 routes

• dodecanoyl-CoAReach from here →
  1. Propanoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (lauric acid)

  Catalysed by ACOT7, SLC27A2, ACSL4, ACSL3 and 5 morecytosolOne of 9 routes

• glutaryl-CoAReach from here →
  1. Propanoyl-CoA hydrolase
  2. Production of Glutaryl Carnitine

  Catalysed by ACOT7, CPT1A, CPT1C, CPT1BcytosolOne of 2 routes

• eicosanoyl-CoAReach from here →
  1. Propanoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (eicosanoate)

  Catalysed by ACOT7, SLC27A2, ACSL4, ACSL3 and 5 morecytosolOne of 12 routes

• itaconyl-CoAReach from here →
  1. Propanoyl-CoA hydrolase
  2. Itaconate:CoA ligase (GDP-forming)

  Catalysed by ACOT7, SUCLG1, SUCLG2, SUCLA2cytosol, mitochondrial matrixOne of 2 routes

• (9Z,12Z)-octadecadienoyl-CoAReach from here →
  1. Propanoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)

  Catalysed by ACOT7, SLC27A2, ACSL4, ACSL3 and 5 morecytosolOne of 13 routes

• tetradecanoyl-CoAReach from here →
  1. Propanoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (myristic acid)

  Catalysed by ACOT7, SLC27A2, ACSL4, ACSL3 and 5 morecytosolOne of 11 routes

• octanoyl-CoAReach from here →
  1. Propanoyl-CoA hydrolase
  2. Octanoyl-CoA:L-carnitine O-octanoyltransferase

  Catalysed by ACOT7, CROTcytosol, mitochondrial matrixOne of 20 routes

• phytanoyl-CoAReach from here →
  1. Propanoyl-CoA hydrolase
  2. phytanate-CoA ligase

  Catalysed by ACOT7cytosolOne of 5 routes

• propanoyl-CoAReach from here →
  1. propanoyl-CoA:carbon-dioxide ligase (ADP-forming)
  2. (S)-methylmalonyl-CoA + H(+) = propanoyl-CoA + CO2

  Catalysed by PCCA, PCCB, ECHDC1mitochondrial matrix

• octadecanoyl-CoAReach from here →
  1. Propanoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (stearate)

  Catalysed by ACOT7, SLC27A2, ACSL4, ACSL3 and 4 morecytosolOne of 15 routes

• O-acetyl-(R)-carnitineReach from here →
  1. Active Transport
  2. Acetyl-CoA:carnitine O-acetyltransferase

  Catalysed by CPT1A, CPT1C, CPT1Bmitochondrial matrix, cytosolOne of 9 routes

• sphing-4-enineReach from here →
  1. Propanoyl-CoA hydrolase
  2. acyl-CoA:sphingosine N-acyltransferase

  Catalysed by ACOT7, ASAH1, ACER2, ACER1 and 1 morecytosol, Golgi apparatusOne of 2 routes

• spermidineReach from here →
  1. Propanoyl-CoA hydrolase
  2. diamine N-acetyltransferase (N1-acetylspermidine)

  Catalysed by ACOT7, SAT1, SAT2cytosolOne of 3 routes

• L-methionineReach from here →
  1. Propanoyl-CoA hydrolase
  2. N-acetylglutamate synthase (N-acetylmethionine)

  Catalysed by ACOT7, NAGScytosol, mitochondrial matrix

• L-alanineReach from here →
  1. Propanoyl-CoA hydrolase
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)

  Catalysed by ACOT7cytosol, mitochondrial matrix

• L-asparagineReach from here →
  1. Propanoyl-CoA hydrolase
  2. N-acetylglutamate synthase (N-acetyl-L-asparagine)

  Catalysed by ACOT7, NAGScytosol, mitochondrial matrix

• L,L-cystathionineReach from here →
  1. Propanoyl-CoA hydrolase
  2. N-acetylglutamate synthase (N-acetyl-L-cystathionine)

  Catalysed by ACOT7, NAGScytosol, mitochondrial matrix

• an acyl-CoAReach from here →
  1. Propanoyl-CoA hydrolase
  2. acyl-CoA:sphingosine N-acyltransferase

  Catalysed by ACOT7, ASAH1, ACER2, ACER1 and 1 morecytosol, Golgi apparatusOne of 2 routes

• (3Z)-dodecenoyl-CoAReach from here →
  1. Propanoyl-CoA hydrolase
  2. acetyl-CoA C-acyltransferase (3-oxomyrist-5-enoyl-CoA)

  Catalysed by ACOT7, HADHA, ACAA2, HADHBcytosol, mitochondrial matrixOne of 3 routes

• (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoAReach from here →
  1. Propanoyl-CoA hydrolase
  2. 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate:CoA ligase (AMP-forming)

  Catalysed by ACOT7, SLC27A2, SLC27A5cytosol, endoplasmic reticulumOne of 3 routes

• deoxycholoyl-CoAReach from here →
  1. Propanoyl-CoA hydrolase
  2. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)

  Catalysed by ACOT7, SLC27A2, SLC27A5cytosolOne of 4 routes

• decanoyl-CoAReach from here →
  1. Propanoyl-CoA hydrolase
  2. medium-chain acyl-CoA ligase (decanoic acid)

  Catalysed by ACOT7, ACSM4, ACSM1, ACSM2A and 3 morecytosolOne of 7 routes

• (2E)-hexadecenoyl-CoAReach from here →
  1. Propanoyl-CoA hydrolase
  2. Carnitine O-Palmitoyltransferase

  Catalysed by ACOT7, CPT1A, CPT1C, CPT1BcytosolOne of 4 routes

• (9Z)-hexadecenoyl-CoAReach from here →
  1. Propanoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (palmitolate)

  Catalysed by ACOT7, SLC27A2, ACSL4, ACSL3 and 5 morecytosolOne of 11 routes

• 3-hydroxyisovaleryl-CoAReach from here →
  1. Propanoyl-CoA hydrolase
  2. (3-Hydroxyisovalerylcoa->3-Hydroxyisovalerylcarnitine)

  Catalysed by ACOT7, CPT1A, CPT1Bcytosol

• CHEBI:63544Reach from here →
  1. Propanoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (adrenic acid)

  Catalysed by ACOT7, SLC27A2, ACSL4, ACSL3 and 5 morecytosolOne of 7 routes

• hexacosanoyl-CoAReach from here →
  1. Propanoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (cerotic acid)

  Catalysed by ACOT7, SLC27A2, ACSL4, ACSL3 and 5 morecytosolOne of 5 routes

• tetracosanoyl-CoAReach from here →
  1. Propanoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (lignocerate)

  Catalysed by ACOT7, SLC27A2, ACSL4, ACSL3 and 5 morecytosolOne of 10 routes

• docosanoyl-CoAReach from here →
  1. Propanoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (behenic acid)

  Catalysed by ACOT7, SLC27A2, ACSL4, ACSL3 and 5 morecytosolOne of 9 routes

• (2E)-octadecenoyl-CoAReach from here →
  1. Propanoyl-CoA hydrolase
  2. Carnitine O-Palmitoyltransferase

  Catalysed by ACOT7, CPT1A, CPT1C, CPT1BcytosolOne of 3 routes

• (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoAReach from here →
  1. Propanoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (stearidonic acid)

  Catalysed by ACOT7, SLC27A2, ACSL4, ACSL3 and 5 morecytosolOne of 8 routes

• (8Z,11Z,14Z)-eicosatrienoateReach from here →
  1. Active Transport
  2. Utilized Transport

  No catalyst recordedmitochondrial matrix, cytosol, endoplasmic reticulum

• (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoAReach from here →
  1. Propanoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (EPA)

  Catalysed by ACOT7, SLC27A2, ACSL4, ACSL3 and 5 morecytosolOne of 9 routes

• (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoAReach from here →
  1. Propanoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (DPA)

  Catalysed by ACOT7, SLC27A2, ACSL4, ACSL3 and 5 morecytosolOne of 6 routes