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Proteins/UNIPROT:Q9H2J7
Functions as a sodium-dependent neutral amino acid transporter. Exhibits preference for the branched-chain amino acids, particularly leucine, valine and isoleucine and methionine. Can also transport low-affinity substrates such as alanine, phenylalanine, glutamine and pipecolic acid. Mediates the saturable, pH-sensitive and electrogenic cotransport of proline and sodium ions with a stoichiometry of 1:1. May have a role as transporter for neurotransmitter precursors into neurons. In contrast to other members of the neurotransmitter transporter family, does not appear to be chloride-dependent..
Function from UniProtKB (Q9H2J7), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · transported by
1 compound
1 compound.
0 reported routes1 assembled route
62 statements
62 statements · 5 reference databases · Subject: SLC6A15 · Sources: Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
24 reactions
L-alanine+sodium(1+)L-alanine+sodium(1+)
Transported by SLC6A15 or SLC1A5 or SLC38A1 or SLC1A4 or SLC38A2 or SLC38A4 or SLC6A19
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR05305CC BY 4.0Reference data
8 names
Resolves to: SLC6A15
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR05308CC BY 4.0Reference data
L-asparagine+sodium(1+)L-asparagine+sodium(1+)
Transported by SLC6A15 or SLC38A1 or SLC38A2 or SLC38A4
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR05311CC BY 4.0Reference data
sodium(1+)+L-valinesodium(1+)+L-valine
Transported by SLC6A15 or SLC6A19
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR05314CC BY 4.0Reference data
L-leucine+sodium(1+)L-leucine+sodium(1+)
Transported by SLC6A15 or SLC38A1 or SLC38A2 or SLC38A4 or SLC3A2 or SLC6A19
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR05315CC BY 4.0Reference data
L-isoleucine+sodium(1+)L-isoleucine+sodium(1+)
Transported by SLC6A15 or SLC6A19
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR05316CC BY 4.0Reference data
sodium(1+)+CHEBI:17203sodium(1+)+CHEBI:17203
Transported by SLC6A7 or SLC6A15 or SLC38A1 or SLC38A2 or SLC38A4 or SLC6A20
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR05322CC BY 4.0Reference data
L-methionine+sodium(1+)L-methionine+sodium(1+)
Transported by SLC6A15 or SLC38A1 or SLC38A2 or SLC38A4 or SLC6A19 or SLC22A5
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR05324CC BY 4.0Reference data
sodium(1+)+CHEBI:16857sodium(1+)+CHEBI:16857
Transported by SLC6A15 or SLC38A1 or SLC38A2 or SLC38A4
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR05326CC BY 4.0Reference data
sodium(1+)+L-seryl residuesodium(1+)+L-seryl residue
Transported by SLC6A15 or SLC38A1 or SLC38A2 or SLC38A4 or SLC6A19
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR06375CC BY 4.0Reference data
L-cysteine+sodium(1+)L-cysteine+sodium(1+)
Transported by SLC6A15 or SLC1A5 or SLC1A4 or SLC38A4 or SLC6A19
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR06377CC BY 4.0Reference data
L-proline+sodium(1+)L-proline+sodium(1+)
Transported by SLC38A4 or SLC38A2 or SLC6A17 or SLC38A1 or SLC6A15
Reaction pageRight to leftBalanced
Rhea RHEA:28967CC BY 4.0Reference data