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Proteins/UNIPROT:Q8WUX1
Symporter that cotransports neutral amino acids and sodium ions, coupled to an H(+) antiporter activity. Releases L-glutamine and glycine from astroglial cells and may participate in the glutamate/GABA-L-glutamine cycle and the NMDA receptors activation (By similarity). In addition, contributes significantly to L-glutamine uptake in retina, namely in ganglion and Mueller cells therefore, participates in the retinal glutamate-glutamine cycle (By similarity). The transport activity is pH sensitive and Li(+) tolerant. Moreover functions in both direction and is associated with large uncoupled fluxes of protons (By similarity). The transport is electroneutral coupled to the cotransport of 1 Na(+) and the antiport of 1 H(+) (By similarity). May have a particular importance for modulation of net hepatic glutamine flux (By similarity)..
Function from UniProtKB (Q8WUX1), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 4 · transported by
4 compounds
4 compounds.
0 reported routes4 assembled routes
75 statements
75 statements · 7 reference databases · Subject: SLC38A5 · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways
17 reactions
L-alanine+proton+2sodium(1+)L-alanine+proton+2sodium(1+)
Transported by SLC38A5 or SLC38A3
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR05307CC BY 4.0Reference data
5 names
Resolves to: SLC38A5
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR05313CC BY 4.0Reference data
L-glutamine+proton+sodium(1+)L-glutamine+proton+sodium(1+)
Transported by SLC38A5 or SLC38A3
Reaction pageReversibleBalancedextracellular space, cytosol
Human-GEM MAR06380CC BY 4.0Reference data
proton+sodium(1+)+L-seryl residueproton+sodium(1+)+L-seryl residue
Transported by SLC38A5 or SLC38A1 or SLC38A2 or SLC38A4
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR06381CC BY 4.0Reference data
L-asparagine+proton+sodium(1+)L-asparagine+proton+sodium(1+)
Transported by SLC38A5 or SLC38A1 or SLC38A2 or SLC38A4
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR06382CC BY 4.0Reference data
proton+CHEBI:15971+sodium(1+)proton+CHEBI:15971+sodium(1+)
Transported by SLC38A5 or SLC38A2
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR06384CC BY 4.0Reference data
L-cysteine+proton+sodium(1+)L-cysteine+proton+sodium(1+)
Transported by SLC38A5
Reaction pageReversibleBalancedextracellular space, cytosol
Human-GEM MAR06887CC BY 4.0Reference data
proton+2sodium(1+)+L-seryl residueproton+2sodium(1+)+L-seryl residue
Transported by SLC38A5
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR08735CC BY 4.0Reference data
L-alanine+proton+sodium(1+)L-alanine+proton+sodium(1+)
Transported by SLC38A5
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR09605CC BY 4.0Reference data
glycine+proton+sodium(1+)glycine+proton+sodium(1+)
Transported by SLC38A5
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR09606CC BY 4.0Reference data
L-glutamine+sodium(1+)+hydronL-glutamine+sodium(1+)+hydron
Transported by SLC38A5 or SLC38A3
Reaction pageReversibleBalanced
Rhea RHEA:71127CC BY 4.0Reference data
L-asparagine+sodium(1+)+hydronL-asparagine+sodium(1+)+hydron
Transported by SLC38A5 or SLC38A3
Reaction pageReversibleBalanced
Rhea RHEA:71131CC BY 4.0Reference data