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Proteins/UNIPROT:Q96I59

NARS2

Protein·UNIPROT:Q96I59Asparaginyl-tRNA synthetase

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Mitochondrial aminoacyl-tRNA synthetase that catalyzes the specific attachment of the asparagine amino acid (aa) to the homologous transfer RNA (tRNA), further participating in protein synthesis. The reaction occurs in a two steps: asparagine is first activated by ATP to form Asn-AMP and then transferred to the acceptor end of tRNA(Asn) (Probable)..

Function from UniProtKB (Q96I59), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

3 rows

combined oxidative phosphorylation defect type 24 has a germline basis in NARS2DiseaseGenCC HGNC:26274|MONDO:0014547Inferred only
hearing loss, autosomal recessive has a germline basis in NARS2DiseaseGenCC HGNC:26274|MONDO:0019588Inferred only
mitochondrial disease has a germline basis in NARS2DiseaseGenCC HGNC:26274|MONDO:0044970Inferred only

Statements

55 statements

55 statements · 5 reference databases · Subject: NARS2 · Sources: Hetionet, Human Protein Atlas, Reactome, Rhea, WikiPathways

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NARS2 is expressed in adipose tissueAnatomyHuman Protein Atlas ENSG00000137513Inferred only
NARS2 is expressed in adrenal glandAnatomyHuman Protein Atlas ENSG00000137513Inferred only
NARS2 is expressed in bone marrowAnatomyHuman Protein Atlas ENSG00000137513Inferred only
NARS2 is expressed in breastAnatomyHuman Protein Atlas ENSG00000137513Inferred only
NARS2 is expressed in bronchusAnatomyHuman Protein Atlas ENSG00000137513Inferred only
NARS2 is expressed in caudate nucleusAnatomyHuman Protein Atlas ENSG00000137513Inferred only
NARS2 is expressed in cerebellumAnatomyHuman Protein Atlas ENSG00000137513Inferred only
NARS2 is expressed in cerebral cortexAnatomyHuman Protein Atlas ENSG00000137513Inferred only
NARS2 is expressed in colonAnatomyHuman Protein Atlas ENSG00000137513Inferred only
NARS2 is expressed in duodenumAnatomyHuman Protein Atlas ENSG00000137513Inferred only
NARS2 is expressed in endometriumAnatomyHuman Protein Atlas ENSG00000137513Inferred only
NARS2 is expressed in epididymisAnatomyHuman Protein Atlas ENSG00000137513Inferred only

Show the remaining 43

NARS2 is expressed in esophagusAnatomyHuman Protein Atlas ENSG00000137513Inferred only
NARS2 is expressed in fallopian tubeAnatomyHuman Protein Atlas ENSG00000137513Inferred only
NARS2 is expressed in gallbladderAnatomyHuman Protein Atlas ENSG00000137513Inferred only
NARS2 is expressed in liverAnatomyHuman Protein Atlas ENSG00000137513Inferred only
NARS2 is expressed in lungAnatomyHuman Protein Atlas ENSG00000137513Inferred only
NARS2 is expressed in lymph nodeAnatomyHuman Protein Atlas ENSG00000137513Inferred only
NARS2 is expressed in mouth mucosaAnatomyHuman Protein Atlas ENSG00000137513Inferred only
NARS2 is expressed in myocardiumAnatomyHuman Protein Atlas ENSG00000137513Inferred only
NARS2 is expressed in nasopharynxAnatomyHuman Protein Atlas ENSG00000137513Inferred only
NARS2 is expressed in ovaryAnatomyHuman Protein Atlas ENSG00000137513Inferred only
NARS2 is expressed in pancreasAnatomyHuman Protein Atlas ENSG00000137513Inferred only
NARS2 is expressed in parathyroid glandAnatomyHuman Protein Atlas ENSG00000137513Inferred only
NARS2 is expressed in placentaAnatomyHuman Protein Atlas ENSG00000137513Inferred only
NARS2 is expressed in prostate glandAnatomyHuman Protein Atlas ENSG00000137513Inferred only
NARS2 is expressed in rectumAnatomyHuman Protein Atlas ENSG00000137513Inferred only
NARS2 is expressed in saliva-secreting glandAnatomyHuman Protein Atlas ENSG00000137513Inferred only
NARS2 is expressed in seminal vesicleAnatomyHuman Protein Atlas ENSG00000137513Inferred only
NARS2 is expressed in Skeletal muscle tissueAnatomyHuman Protein Atlas ENSG00000137513Inferred only
NARS2 is expressed in Small intestineAnatomyHuman Protein Atlas ENSG00000137513Inferred only
NARS2 is expressed in smooth muscle tissueAnatomyHuman Protein Atlas ENSG00000137513Inferred only
NARS2 is expressed in spleenAnatomyHuman Protein Atlas ENSG00000137513Inferred only
NARS2 is expressed in stomachAnatomyHuman Protein Atlas ENSG00000137513Inferred only
NARS2 is expressed in testisAnatomyHuman Protein Atlas ENSG00000137513Inferred only
NARS2 is expressed in thyroid glandAnatomyHuman Protein Atlas ENSG00000137513Inferred only
NARS2 is expressed in tonsilAnatomyHuman Protein Atlas ENSG00000137513Inferred only
NARS2 is expressed in urinary bladderAnatomyHuman Protein Atlas ENSG00000137513Inferred only
NARS2 is expressed in uterine cervixAnatomyHuman Protein Atlas ENSG00000137513Inferred only
NARS2 is expressed in vaginaAnatomyHuman Protein Atlas ENSG00000137513Inferred only
NARS2 is expressed in vermiform appendixAnatomyHuman Protein Atlas ENSG00000137513Inferred only
NARS2 is expressed in zone of skinAnatomyHuman Protein Atlas ENSG00000137513Inferred only
NARS2 participates in Ectoderm differentiationPathwayWikiPathways WP2858Inferred only
NARS2 participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only
NARS2 participates in Mitochondrial tRNA aminoacylationPathwayReactome R-HSA-379726Inferred only
NARS2 participates in TranslationPathwayReactome R-HSA-72766Inferred only
NARS2 participates in tRNA AminoacylationPathwayReactome R-HSA-379724Inferred only
ALG9 increases the expression of NARS2ProteinHetionet hetionet:regulates:79796-79731Inferred only
AMDHD2 decreases the expression of NARS2ProteinHetionet hetionet:regulates:51005-79731Inferred only
FHL2 increases the expression of NARS2ProteinHetionet hetionet:regulates:2274-79731Inferred only
GNAS decreases the expression of NARS2ProteinHetionet hetionet:regulates:2778-79731Inferred only
NR4A1 increases the expression of NARS2ProteinHetionet hetionet:regulates:3164-79731Inferred only
PAK1 increases the expression of NARS2ProteinHetionet hetionet:regulates:5058-79731Inferred only
PXN increases the expression of NARS2ProteinHetionet hetionet:regulates:5829-79731Inferred only
L-asparagine is a substrate of NARS2CompoundRhea RHEA:11180Inferred only

Reactions

1 reaction

CHEBI:78442+L-asparagine+ATP(4-)CHEBI:78515+AMP+diphosphate(3-)+hydron
Catalysed by NARS1 or NARS2
Reaction pageDirection not assertedBalanced
Rhea RHEA:11180CC BY 4.0Reference data

Other names

2 names

Resolves to: NARS2

Also called: AsnRSAsparagine--tRNA ligase, mitochondrial

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