Pathway
Nuclear events mediated by NFE2L2
In response to chemical and other stressors, the constitutive degradation of NFE2L2 by the KEAP1:CUL3:26S proteasome system is disrupted, allowing NFE2L2 to accumulate. Stabilized NFE2L2 translocates to the nucleus where it binds to antioxidant response elements (AREs) in the promoters and enhancers of target genes to upregulate their expression (reviewed in Baird and Yamamoto, 2020).
REACT:R-HSA-9759194Reactome
What the reference databases state
Statements
86 statements
86 statements · 1 reference database · Subject: Nuclear events mediated by NFE2L2 · Sources: Reactome
- ABCC1 participates in Nuclear events mediated by NFE2L2ProteinReactome R-HSA-9759194Inferred only
- ABCC3 participates in Nuclear events mediated by NFE2L2ProteinReactome R-HSA-9759194Inferred only
- ABCF2 participates in Nuclear events mediated by NFE2L2ProteinReactome R-HSA-9759194Inferred only
- ABCG2 participates in Nuclear events mediated by NFE2L2ProteinReactome R-HSA-9759194Inferred only
- ADRM1 participates in Nuclear events mediated by NFE2L2ProteinReactome R-HSA-9759194Inferred only
- AREG participates in Nuclear events mediated by NFE2L2ProteinReactome R-HSA-9759194Inferred only
- ATF4 participates in Nuclear events mediated by NFE2L2ProteinReactome R-HSA-9759194Inferred only
- BACH1 participates in Nuclear events mediated by NFE2L2ProteinReactome R-HSA-9759194Inferred only
- BCL2 participates in Nuclear events mediated by NFE2L2ProteinReactome R-HSA-9759194Inferred only
- BCL2L1 participates in Nuclear events mediated by NFE2L2ProteinReactome R-HSA-9759194Inferred only
- BTRC participates in Nuclear events mediated by NFE2L2ProteinReactome R-HSA-9759194Inferred only
- CCL2 participates in Nuclear events mediated by NFE2L2ProteinReactome R-HSA-9759194Inferred only
Show the remaining 74
- CDKN2A participates in Nuclear events mediated by NFE2L2ProteinReactome R-HSA-9759194Inferred only
- CHD6 participates in Nuclear events mediated by NFE2L2ProteinReactome R-HSA-9759194Inferred only
- CREBBP participates in Nuclear events mediated by NFE2L2ProteinReactome R-HSA-9759194Inferred only
- CUL1 participates in Nuclear events mediated by NFE2L2ProteinReactome R-HSA-9759194Inferred only
- EGF participates in Nuclear events mediated by NFE2L2ProteinReactome R-HSA-9759194Inferred only
- EP300 participates in Nuclear events mediated by NFE2L2ProteinReactome R-HSA-9759194Inferred only
- G6PD participates in Nuclear events mediated by NFE2L2ProteinReactome R-HSA-9759194Inferred only
- GCLC participates in Nuclear events mediated by NFE2L2ProteinReactome R-HSA-9759194Inferred only
- GCLM participates in Nuclear events mediated by NFE2L2ProteinReactome R-HSA-9759194Inferred only
- GSK3B participates in Nuclear events mediated by NFE2L2ProteinReactome R-HSA-9759194Inferred only
- GSTA1 participates in Nuclear events mediated by NFE2L2ProteinReactome R-HSA-9759194Inferred only
- GSTA3 participates in Nuclear events mediated by NFE2L2ProteinReactome R-HSA-9759194Inferred only
- HMOX1 participates in Nuclear events mediated by NFE2L2ProteinReactome R-HSA-9759194Inferred only
- IDH1 participates in Nuclear events mediated by NFE2L2ProteinReactome R-HSA-9759194Inferred only
- KEAP1 participates in Nuclear events mediated by NFE2L2ProteinReactome R-HSA-9759194Inferred only
- MAFG participates in Nuclear events mediated by NFE2L2ProteinReactome R-HSA-9759194Inferred only
- MAFK participates in Nuclear events mediated by NFE2L2ProteinReactome R-HSA-9759194Inferred only
- ME1 participates in Nuclear events mediated by NFE2L2ProteinReactome R-HSA-9759194Inferred only
- MYC participates in Nuclear events mediated by NFE2L2ProteinReactome R-HSA-9759194Inferred only
- NFE2L2 participates in Nuclear events mediated by NFE2L2ProteinReactome R-HSA-9759194Inferred only
- NFKB1 participates in Nuclear events mediated by NFE2L2ProteinReactome R-HSA-9759194Inferred only
- NOTCH1 participates in Nuclear events mediated by NFE2L2ProteinReactome R-HSA-9759194Inferred only
- NQO1 participates in Nuclear events mediated by NFE2L2ProteinReactome R-HSA-9759194Inferred only
- PDGFA participates in Nuclear events mediated by NFE2L2ProteinReactome R-HSA-9759194Inferred only
- PGD participates in Nuclear events mediated by NFE2L2ProteinReactome R-HSA-9759194Inferred only
- PRDX1 participates in Nuclear events mediated by NFE2L2ProteinReactome R-HSA-9759194Inferred only
- PRKAA2 participates in Nuclear events mediated by NFE2L2ProteinReactome R-HSA-9759194Inferred only
- PSMA1 participates in Nuclear events mediated by NFE2L2ProteinReactome R-HSA-9759194Inferred only
- PSMA2 participates in Nuclear events mediated by NFE2L2ProteinReactome R-HSA-9759194Inferred only
- PSMA3 participates in Nuclear events mediated by NFE2L2ProteinReactome R-HSA-9759194Inferred only
- PSMA4 participates in Nuclear events mediated by NFE2L2ProteinReactome R-HSA-9759194Inferred only
- PSMA5 participates in Nuclear events mediated by NFE2L2ProteinReactome R-HSA-9759194Inferred only
- PSMA6 participates in Nuclear events mediated by NFE2L2ProteinReactome R-HSA-9759194Inferred only
- PSMA7 participates in Nuclear events mediated by NFE2L2ProteinReactome R-HSA-9759194Inferred only
- PSMB1 participates in Nuclear events mediated by NFE2L2ProteinReactome R-HSA-9759194Inferred only
- PSMB2 participates in Nuclear events mediated by NFE2L2ProteinReactome R-HSA-9759194Inferred only
- PSMB3 participates in Nuclear events mediated by NFE2L2ProteinReactome R-HSA-9759194Inferred only
- PSMB4 participates in Nuclear events mediated by NFE2L2ProteinReactome R-HSA-9759194Inferred only
- PSMB5 participates in Nuclear events mediated by NFE2L2ProteinReactome R-HSA-9759194Inferred only
- PSMB6 participates in Nuclear events mediated by NFE2L2ProteinReactome R-HSA-9759194Inferred only
- PSMB7 participates in Nuclear events mediated by NFE2L2ProteinReactome R-HSA-9759194Inferred only
- PSMC1 participates in Nuclear events mediated by NFE2L2ProteinReactome R-HSA-9759194Inferred only
- PSMC2 participates in Nuclear events mediated by NFE2L2ProteinReactome R-HSA-9759194Inferred only
- PSMC3 participates in Nuclear events mediated by NFE2L2ProteinReactome R-HSA-9759194Inferred only
- PSMC4 participates in Nuclear events mediated by NFE2L2ProteinReactome R-HSA-9759194Inferred only
- PSMC5 participates in Nuclear events mediated by NFE2L2ProteinReactome R-HSA-9759194Inferred only
- PSMC6 participates in Nuclear events mediated by NFE2L2ProteinReactome R-HSA-9759194Inferred only
- PSMD1 participates in Nuclear events mediated by NFE2L2ProteinReactome R-HSA-9759194Inferred only
- PSMD11 participates in Nuclear events mediated by NFE2L2ProteinReactome R-HSA-9759194Inferred only
- PSMD12 participates in Nuclear events mediated by NFE2L2ProteinReactome R-HSA-9759194Inferred only
- PSMD13 participates in Nuclear events mediated by NFE2L2ProteinReactome R-HSA-9759194Inferred only
- PSMD14 participates in Nuclear events mediated by NFE2L2ProteinReactome R-HSA-9759194Inferred only
- PSMD2 participates in Nuclear events mediated by NFE2L2ProteinReactome R-HSA-9759194Inferred only
- PSMD3 participates in Nuclear events mediated by NFE2L2ProteinReactome R-HSA-9759194Inferred only
- PSMD6 participates in Nuclear events mediated by NFE2L2ProteinReactome R-HSA-9759194Inferred only
- PSMD7 participates in Nuclear events mediated by NFE2L2ProteinReactome R-HSA-9759194Inferred only
- PSMD8 participates in Nuclear events mediated by NFE2L2ProteinReactome R-HSA-9759194Inferred only
- RBX1 participates in Nuclear events mediated by NFE2L2ProteinReactome R-HSA-9759194Inferred only
- RELA participates in Nuclear events mediated by NFE2L2ProteinReactome R-HSA-9759194Inferred only
- RPS27A participates in Nuclear events mediated by NFE2L2ProteinReactome R-HSA-9759194Inferred only
- SEM1 participates in Nuclear events mediated by NFE2L2ProteinReactome R-HSA-9759194Inferred only
- SKP1 participates in Nuclear events mediated by NFE2L2ProteinReactome R-HSA-9759194Inferred only
- SLC7A11 participates in Nuclear events mediated by NFE2L2ProteinReactome R-HSA-9759194Inferred only
- SOD3 participates in Nuclear events mediated by NFE2L2ProteinReactome R-HSA-9759194Inferred only
- SP1 participates in Nuclear events mediated by NFE2L2ProteinReactome R-HSA-9759194Inferred only
- SQSTM1 participates in Nuclear events mediated by NFE2L2ProteinReactome R-HSA-9759194Inferred only
- SRXN1 participates in Nuclear events mediated by NFE2L2ProteinReactome R-HSA-9759194Inferred only
- TALDO1 participates in Nuclear events mediated by NFE2L2ProteinReactome R-HSA-9759194Inferred only
- TKT participates in Nuclear events mediated by NFE2L2ProteinReactome R-HSA-9759194Inferred only
- TXN participates in Nuclear events mediated by NFE2L2ProteinReactome R-HSA-9759194Inferred only
- TXNRD1 participates in Nuclear events mediated by NFE2L2ProteinReactome R-HSA-9759194Inferred only
- UBA52 participates in Nuclear events mediated by NFE2L2ProteinReactome R-HSA-9759194Inferred only
- UBB participates in Nuclear events mediated by NFE2L2ProteinReactome R-HSA-9759194Inferred only
- UBC participates in Nuclear events mediated by NFE2L2ProteinReactome R-HSA-9759194Inferred only