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1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

Inferred

Every route here is a hypothesis drawn from reference reactions (Rhea and Human-GEM), not a finding. Currency species such as water, ATP and NAD(H) never form a step. Evidence key

342 compounds within 3 steps: 4 in 1, 48 in 2, 290 in 3

Does it reach a compound?

Two steps

O-octadecanoyl-(R)-carnitineReach from here →
1. 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA
2. (R)-carnitine + octadecanoyl-CoA = O-octadecanoyl-(R)-carnitine + CoA
Catalysed by LPGAT1, CPT2
1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholineReach from here →
1. 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA
2. 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + CoA
Catalysed by LPGAT1

Three steps

(S)-carnitineReach from here →
Catalysed by LPGAT1, ACOT7, BAAT, THEM4 and 5 morecytosolOne of 244 routes
CHEBI:1307929Reach from here →

Page 2 of 7

Catalysed by LPGAT1, SOAT2, SOAT1, CEL and 1 moreendoplasmic reticulum, lysosomeOne of 2 routes

an acyl-4'-phosphopantetheineReach from here →

2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA
acyl-CoA pool formation and breakdown
an acyl-CoA + H2O = an acyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)

Catalysed by LPGAT1, NUDT19, FITM2, NUDT8cytosol

1-(9Z-octadecenoyl)-3-(9Z,12Z-octadecadienoyl)-glycerolReach from here →

2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA
octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
1-(9Z,12Z-octadecadienoyl)-glycerol + (9Z)-octadecenoyl-CoA = 1-(9Z-octadecenoyl)-3-(9Z,12Z-octadecadienoyl)-glycerol + CoA

Catalysed by LPGAT1, SCD, SCD5, MOGAT2 and 1 more

N-(9Z-octadecenoyl)glycineReach from here →

2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA
octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
(9Z)-octadecenoyl-CoA + glycine = N-(9Z-octadecenoyl)glycine + CoA + H(+)

Catalysed by LPGAT1, SCD, SCD5, GLYATL3 and 1 more

1-O-(9Z-octadecenyl)-2,3-di-(9Z-octadecenoyl)glycerolReach from here →

2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA
octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
1-O-(9Z-octadecyl)-3-(9Z-octadecenoyl)-glycerol + (9Z)-octadecenoyl-CoA = 1-O-(9Z-octadecenyl)-2,3-di-(9Z-octadecenoyl)glycerol + CoA

Catalysed by LPGAT1, SCD, SCD5, DGAT1 and 2 more

sn-glycero-3-phosphoethanolamineReach from here →

2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA
1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine
1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-sn-glycero-3-phosphocholine = sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine

Catalysed by LPGAT1, TAFAZZIN, PLA2G4C

1-octadecanoyl-2-(15-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phosphocholineReach from here →

1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z,12Z-octadecadienoyl)-N-acetylsphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphocholine
1-octadecanoyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA
1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + O2 = 1-octadecanoyl-2-(15-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phosphocholine

Catalysed by PLA2G15, LPCAT3, ALOX15B

1-O-(1Z-alkenyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamineReach from here →

2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA
1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine
1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine = 1-O-(1Z-alkenyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-sn-glycero-3-phosphocholine

Catalysed by LPGAT1, TAFAZZIN, PLA2G4C

cholesteryl (7Z)-octadecenoateReach from here →

2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA
stearoyl-CoA 9-desaturase (stearoyl-CoA)
(7Z)-octadecenoyl-CoA + cholesterol = cholesteryl (7Z)-octadecenoate + CoA

Catalysed by LPGAT1, SCD, SCD5, SOAT1cytosol

CHEBI:15345Reach from here →

2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA
Stearoyl-CoA hydrolase
Acetoacetate:CoA ligase (AMP-forming)

Catalysed by LPGAT1, ACOT7, BAAT, THEM4 and 3 morecytosolOne of 2 routes

acetylcholineReach from here →

1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z,12Z-octadecadienoyl)-N-acetylsphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphocholine
1-octadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphate + choline + H(+)
Acetyl-CoA:choline O-acetyltransferase

Catalysed by PLA2G15, ENPP2, CHATcytosolOne of 3 routes

CHEBI:15380Reach from here →

2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA
Stearoyl-CoA hydrolase
5-aminolevulinate synthase (2-amino-3-oxoadipate)

Catalysed by LPGAT1, ACOT7, BAAT, THEM4 and 4 morecytosol, mitochondrial matrixOne of 8 routes

CHEBI:15477Reach from here →

2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA
Stearoyl-CoA hydrolase
glycine N-acyltransferase (2-methylbutyryl-CoA)

Catalysed by LPGAT1, ACOT7, BAAT, THEM4 and 5 morecytosol, mitochondrial matrixOne of 2 routes

2-methylcrotonoyl-CoAReach from here →

2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA
Stearoyl-CoA hydrolase
Production of Tiglylcarnitine

Catalysed by LPGAT1, ACOT7, BAAT, THEM4 and 4 morecytosolOne of 2 routes

isobutyryl-CoAReach from here →

2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA
Stearoyl-CoA hydrolase
acetyl-CoA C-acyltransferase (3-oxo-4-methyl-pentanoyl-CoA)

Catalysed by LPGAT1, ACOT7, BAAT, THEM4 and 5 morecytosol, mitochondrial matrixOne of 3 routes

3-methylbut-2-enoyl-CoAReach from here →

2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA
Stearoyl-CoA hydrolase
glycine-N-acyltransferase (3-methylcrotonoylglycine)

Catalysed by LPGAT1, ACOT7, BAAT, THEM4 and 3 morecytosol, mitochondrial matrix

isovaleryl-CoAReach from here →

2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA
Stearoyl-CoA hydrolase
glycine N-acyltransferase (isovalerylglycine)

Catalysed by LPGAT1, ACOT7, BAAT, THEM4 and 5 morecytosol, mitochondrial matrixOne of 3 routes

arachidonoyl-CoAReach from here →

2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA
Stearoyl-CoA hydrolase
Arachidonate:CoA ligase (AMP-forming)

Catalysed by LPGAT1, ACOT7, BAAT, THEM4 and 10 morecytosolOne of 12 routes

CHEBI:15519Reach from here →

2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA
Stearoyl-CoA hydrolase
propanoyl-CoA C-acyltransferase

Catalysed by LPGAT1, ACOT7, BAAT, THEM4 and 5 morecytosol, peroxisomeOne of 2 routes

phenylacetyl-CoAReach from here →

2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA
Stearoyl-CoA hydrolase
Phenylacetate:CoA ligase

Catalysed by LPGAT1, ACOT7, BAAT, THEM4 and 2 morecytosolOne of 3 routes

propionyl-CoAReach from here →

2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA
Stearoyl-CoA hydrolase
Propanoate:CoA ligase (AMP-forming)

Catalysed by LPGAT1, ACOT7, BAAT, THEM4 and 5 morecytosolOne of 43 routes

1-(10Z-heptadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamineReach from here →

2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA
octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
1-(10Z-heptadecenoyl)-sn-glycero-3-phosphoethanolamine + (9Z)-octadecenoyl-CoA = 1-(10Z-heptadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA

Catalysed by LPGAT1, SCD, SCD5, MBOAT1

CHEBI:15650Reach from here →

2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA
Stearoyl-CoA hydrolase
N-acetyl-LTE4 to leukotriene E4 conversion

Catalysed by LPGAT1, ACOT7, BAAT, THEM4 and 34 morecytosolOne of 2 routes

S-(9Z-octadecenoyl)-4'-phosphopantetheineReach from here →

2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA
octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
(9Z)-octadecenoyl-CoA + H2O = S-(9Z-octadecenoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)

Catalysed by LPGAT1, SCD, SCD5, FITM2

betaine aldehydeReach from here →

1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z,12Z-octadecadienoyl)-N-acetylsphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphocholine
1-octadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphate + choline + H(+)
choline dehydrogenase (choline)

Catalysed by PLA2G15, ENPP2, CHDHcytosolOne of 3 routes

CHEBI:15727Reach from here →

2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA
Stearoyl-CoA hydrolase
N-alpha-acetyltransferase 10, NatA catalytic subunit (acetylcarnosine)

Catalysed by LPGAT1, ACOT7, BAAT, THEM4 and 3 morecytosol

CHEBI:15746Reach from here →

2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA
Stearoyl-CoA hydrolase
diamine N-acetyltransferase (N1-acetylspermine)

Catalysed by LPGAT1, ACOT7, BAAT, THEM4 and 4 morecytosolOne of 2 routes

hexadecanoic acidReach from here →

2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA
Beta Oxidation of Long Chain Fatty Acid
Palmitoyl-CoA hydrolase

Catalysed by LPGAT1, ACAA1, HSD17B4, EHHADH and 6 moreperoxisome, cytosolOne of 2 routes

1-acylglycerone 3-phosphateReach from here →

2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA
acyl-CoA pool formation and breakdown
Acyl-CoA:glycerone-phosphate O-acyltransferase

Catalysed by LPGAT1, GNPATcytosol

CHEBI:15978Reach from here →

1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z,12Z-octadecadienoyl)-N-acetylsphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphocholine
1-octadecanoyl-sn-glycero-3-phosphocholine + H2O = octadecanoate + sn-glycerol 3-phosphocholine + H(+)
sn-Glycero-3-phosphocholine glycerophosphohydrolase

Catalysed by PLA2G15, LYPLA2, ASPG, GPCPD1cytosol

phosphatidylethanolamineReach from here →

2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA
acyl-CoA pool formation and breakdown
Acyl-CoA:1-acyl-sn-glycero-3-phosphoethanolamine O-acyltransferase

Catalysed by LPGAT1, LPCAT4, LPCAT3, LPCAT2 and 1 morecytosol

1,2-diacyl-sn-glycero-3-phosphocholine(1+)Reach from here →

2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA
acyl-CoA pool formation and breakdown
Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase

Catalysed by LPGAT1, LPCAT4, LPCAT3, LPCAT2 and 1 morecytosol

cholesterolReach from here →

2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA
sphing-4-enine + octadecanoyl-CoA = N-octadecanoylsphing-4-enine + CoA + H(+)
beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-octadecanoylsphing-4-enine

Catalysed by LPGAT1, CERS1, TLCD3B, CERS2 and 2 more

hexadecan-1-olReach from here →

2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA
Beta Oxidation of Long Chain Fatty Acid
formate dehydrogenase (palmitoyl-CoA)

Catalysed by LPGAT1, ACAA1, HSD17B4, EHHADH and 3 moreperoxisome

11-cis-retinyl hexadecanoateReach from here →

2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA
Beta Oxidation of Long Chain Fatty Acid
Palmitoyl-CoA:retinol O-acyltransferase

Catalysed by LPGAT1, ACAA1, HSD17B4, EHHADH and 6 moreperoxisome, cytosol

11-cis-retinolReach from here →

2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA
Stearoyl-CoA hydrolase
Palmitoyl-CoA:retinol O-acyltransferase

Catalysed by LPGAT1, ACOT7, BAAT, THEM4 and 7 morecytosol

phosphatidic acidReach from here →

2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA
acyl-CoA pool formation and breakdown
acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase

Catalysed by LPGAT1, AGPAT2, LCLAT1, MBOAT1 and 6 morecytosol, mitochondrial matrixOne of 7 routes

(R)-carnitineReach from here →

2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA
(R)-carnitine + octadecanoyl-CoA = O-octadecanoyl-(R)-carnitine + CoA
(R)-carnitine + octadecanoyl-CoA = O-octadecanoyl-(R)-carnitine + CoA

Catalysed by LPGAT1, CPT2

oxaloacetateReach from here →

2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA
Stearoyl-CoA hydrolase
ATP citrate lyase (citrate)

Catalysed by LPGAT1, ACOT7, BAAT, THEM4 and 3 morecytosol

1-acyl-sn-glycerol 3-phosphateReach from here →

1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z,12Z-octadecadienoyl)-N-acetylsphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphocholine
1-octadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphate + choline + H(+)
1-acylglycerol-3P-LD-TG1 pool (liver tissue) formation

Catalysed by PLA2G15, ENPP2cytosolOne of 9 routes

a cholesterol esterReach from here →

2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA
Acyl-CoA:cholesterol O-acyltransferase
cholesterol-ester plasma pool to cholesterol-ester-10,13,16,19-docosa conversion

Catalysed by LPGAT1, SOAT2, SOAT1endoplasmic reticulumOne of 4 routes

octadecanalReach from here →

1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z,12Z-octadecadienoyl)-N-acetylsphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphocholine
1-octadecanoyl-sn-glycero-3-phosphocholine + H2O = octadecanoate + sn-glycerol 3-phosphocholine + H(+)
octadecanal + NAD(+) + H2O = octadecanoate + NADH + 2 H(+)

Catalysed by PLA2G15, LYPLA2, ASPG, ALDH3A2

anilineReach from here →

2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA
Stearoyl-CoA hydrolase
Acetyl-CoA:arylamine N-acetyltransferase

Catalysed by LPGAT1, ACOT7, BAAT, THEM4 and 4 morecytosol

CHEBI:17312Reach from here →

2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA
Stearoyl-CoA hydrolase
N1,N12-diacetylspermine to N1-acetylspermine conversion

Catalysed by LPGAT1, ACOT7, BAAT, THEM4 and 2 morecytosolOne of 2 routes

1-(alk-1-enyl)-2-acyl-sn-glycero-3-phosphoethanolamineReach from here →

2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA
acyl-CoA pool formation and breakdown
Acyl-CoA:1-alkenylglycerophosphoethanolamine O-acyltransferase

Catalysed by LPGAT1, LPCAT4, LPCAT3, LPCAT2 and 1 morecytosol

O-hexadecanoyl-(R)-carnitineReach from here →

2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA
Beta Oxidation of Long Chain Fatty Acid
palmitoyl-CoA:L-carnitine O-palmitoyltransferase

Catalysed by LPGAT1, ACAA1, HSD17B4, EHHADH and 3 moreperoxisomeOne of 4 routes

AH2Reach from here →

1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z,12Z-octadecadienoyl)-N-acetylsphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphocholine
1-octadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphate + choline + H(+)
choline + A = betaine aldehyde + AH2

Catalysed by PLA2G15, ENPP2, CHDH