N-hexadecanoylsphing-4-enine

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

391 compounds within 3 steps: 6 in 1, 63 in 2, 322 in 3

One step

hexadecanoic acidReach from here →
1. H2O[c] + N-hexadecanoylsphing-4-enine[c] = palmitate[c] + sphingosine[c]
Catalysed by NAAAnucleus, cytosol
cholesterolReach from here →
1. beta-D-glucosyl-(1<->1')-N-hexadecanoylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-hexadecanoylsphing-4-enine
Catalysed by GBA1
sphing-4-enineReach from here →
1. H2O[c] + N-hexadecanoylsphing-4-enine[c] = palmitate[c] + sphingosine[c]
Catalysed by NAAAnucleus, cytosolOne of 2 routes
N-(hexadecanoyl)-sphing-4-enine-1-phosphateReach from here →
1. N-hexadecanoylsphing-4-enine + ATP = N-(hexadecanoyl)-sphing-4-enine-1-phosphate + ADP + H(+)
Catalysed by CERK
hexadecanoateReach from here →
1. N-hexadecanoylsphing-4-enine + H2O = sphing-4-enine + hexadecanoate
Catalysed by NAAA, ASAH1, ACER2, ASAH2
beta-D-glucosyl-(1<->1')-N-hexadecanoylsphing-4-enineReach from here →
1. beta-D-glucosyl-(1<->1')-N-hexadecanoylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-hexadecanoylsphing-4-enine
Catalysed by GBA1

Two steps

(S)-carnitineReach from here →
1. H2O[c] + N-hexadecanoylsphing-4-enine[c] = palmitate[c] + sphingosine[c]
2. Utilized Transport
Catalysed by NAAAnucleus, cytosol, endoplasmic reticulumOne of 2 routes
CHEBI:1146900Reach from here →
1. H2O[c] + N-hexadecanoylsphing-4-enine[c] = palmitate[c] + sphingosine[c]
2. Fas180
Catalysed by NAAAnucleus, cytosol
AReach from here →

beta-D-glucosyl-(1<->1')-N-hexadecanoylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-hexadecanoylsphing-4-enine

cholesterol + AH2 + O2 = 25-hydroxycholesterol + A + H2O

Catalysed by GBA1, CH25H

cholesterol sulfateReach from here →

Catalysed by GBA1, SULT2B1, SULT1C2

(11Z,14Z,17Z-eicosatrienoyl)-cholesterolReach from here →

Catalysed by GBA1, LCAT

cholesteryl (7Z)-octadecenoateReach from here →

Catalysed by GBA1, SOAT1

palmitoyl-CoAReach from here →

Catalysed by NAAA, SLC27A2, ACSL4, ACSL3 and 5 morenucleus, cytosolOne of 3 routes

beta-D-glucoseReach from here →

Catalysed by GBA1, LCT

pregnenoloneReach from here →

Catalysed by GBA1, CYP11A1

psychosineReach from here →

Catalysed by NAAAnucleus, cytosol

a cholesterol esterReach from here →

Catalysed by GBA1, SOAT2, SOAT1

cholesteryl 3-beta-D-glucosideReach from here →

Catalysed by GBA1, GBA2One of 8 routes

7alpha-hydroxycholesterolReach from here →

Catalysed by GBA1, CYP7A1

hexadecanalReach from here →

Catalysed by NAAA, ALDH3B1, ALDH3B2, ALDH3A2nucleus, cytosolOne of 3 routes

all-trans-retinyl hexadecanoateReach from here →

Catalysed by NAAA, ASAH1, ACER2, ASAH2 and 1 more

26-hydroxycholesterolReach from here →

Catalysed by GBA1, CYP3A4

4-methylpentanalReach from here →

Catalysed by GBA1, CYP11A1

cholesteryl 3-beta-D-galactosideReach from here →

Catalysed by GBA1, GBA2One of 2 routes

cholesteryl 3-beta-D-xylosideReach from here →

Catalysed by GBA1, GBA3One of 2 routes

S-hexadecanoyl-N-acetylcysteamineReach from here →

Catalysed by NAAA, ASAH1, ACER2, ASAH2 and 2 more

S-hexadecanoyl-N-acetylcysteine methyl esterReach from here →

Catalysed by NAAA, ASAH1, ACER2, ASAH2 and 1 more

octadecanoateReach from here →

Catalysed by NAAAnucleus, cytosol

(24S)-hydroxycholesterolReach from here →

Catalysed by GBA1, CYP46A1

fatty acidReach from here →

Catalysed by NAAAnucleus, cytosolOne of 4 routes

cholesteryl hexadecanoateReach from here →

Catalysed by GBA1, SOAT1

sphingosine 1-phosphateReach from here →

Catalysed by NAAA, DBP, SPHK2, SPHK1nucleus, cytosolOne of 2 routes

cholesteryl (9Z,12Z)-octadecadienoateReach from here →

Catalysed by GBA1, SOAT1One of 2 routes

25-hydroxycholesterolReach from here →

Catalysed by GBA1, CH25HOne of 3 routes

N-octanoylsphing-4-enineReach from here →

Catalysed by GBA1

cholesteryl (9Z-octadecenoate)Reach from here →

Catalysed by GBA1, SOAT2, SOAT1One of 2 routes

N-(acetyl)-sphing-4-enineReach from here →

Catalysed by NAAA, PAFAH2nucleus, cytosolOne of 2 routes

(24R)-hydroxycholesterolReach from here →

Catalysed by GBA1, CYP3A4

an N-acylsphing-4-enineReach from here →

Catalysed by NAAA, CERS1, CERS6, CERS3 and 3 morenucleus, cytosolOne of 4 routes

16-hydroxyhexadecanoateReach from here →

Catalysed by NAAA, CYP4F2, CYP4F3nucleus, cytosol, endoplasmic reticulumOne of 3 routes

hexadecanoyl-CoAReach from here →

Catalysed by NAAA, ASAH1, ACER2, ASAH2 and 11 more

a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)Reach from here →

Catalysed by GBA1, OSBPinner side of the membrane, outer side of the membraneOne of 2 routes

a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)Reach from here →

Catalysed by GBA1, OSBP2, OSBPL2inner side of the membrane, outer side of the membraneOne of 2 routes

sphing-4-enine 1-phosphateReach from here →

Catalysed by NAAA, SPHK2, SPHK1nucleus, cytosol

1-O-hexadecyl-sn-glycero-3-phosphocholineReach from here →

Catalysed by NAAA, PAFAH2nucleus, cytosol

(22R)-hydroxycholesterolReach from here →

Catalysed by GBA1, CYP11A1One of 2 routes

N-dodecanoylsphing-4-enineReach from here →

Catalysed by NAAA, ASAH1, ACER2, ASAH2nucleus, cytosolOne of 3 routes

N-tetradecanoylsphing-4-enineReach from here →

Catalysed by NAAA, ASAH1, ACER2, ASAH2nucleus, cytosol

N-octadecanoylsphing-4-enineReach from here →

Catalysed by NAAA, CERS1, TLCD3B, CERS2 and 1 morenucleus, cytosolOne of 3 routes

N-eicosanoyl-sphing-4-enineReach from here →

Catalysed by NAAA, TLCD3B, CERS2nucleus, cytosol