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Proteins/UNIPROT:Q10586
This transcriptional activator recognizes and binds to the sequence 5'-RTTAYGTAAY-3' found in the promoter of genes such as albumin, CYP2A4 and CYP2A5. It is not essential for circadian rhythm generation, but modulates important clock output genes. May be a direct target for regulation by the circadian pacemaker component clock. May affect circadian period and sleep regulation. Activates transcription of coagulation factors F8 and F9; transactivation activity is enhanced by formation of a heterodimer with HLF..
Function from UniProtKB (Q10586), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
32 statements
32 statements · 5 reference databases · Subject: DBP · Sources: gene ontology, Hetionet, Human-GEM, Reactome, WikiPathways
2 reactions
ATP+CHEBI:16566ADP+proton+sphinganine 1-phosphate
Catalysed by SPHK2 or DBP or SPHK1
Reaction pageLeft to rightBalancedEC 2.7.1.91cytosol
Human-GEM MAR00744CC BY 4.0Reference data
4 names
Resolves to: DBP
Reaction pageLeft to rightBalancedEC 2.7.1.91cytosol
Human-GEM MAR00773CC BY 4.0Reference data