L-cysteinylglycine

Three steps

• (3Z)-dodecenoyl-CoAReach from here →
  1. L-cysteinylglycine dipeptidase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. acetyl-CoA C-acyltransferase (3-oxomyrist-5-enoyl-CoA)

  Catalysed by ANPEP, LAP3, NPEPPS, NAGS and 3 morecytosol, mitochondrial matrixOne of 3 routes

• N(tau)-methylhistamineReach from here →
  1. gamma-glutamyltransferase (alanine)
  2. transport of GSH and histamine (cytosol to extracellular)
  3. S-Adenosyl-L-methionine:histamine N-tele-methyltransferase

  Catalysed by GGTLC3, GGT1, GGT5, GGTLC2 and 5 morecytosol, extracellular spaceOne of 3 routes

• N-formyl-L-kynurenineReach from here →
  1. L-cysteinylglycine dipeptidase
  2. transport of cysteine and tryptophan (cytosol to extracellular)
  3. L-tryptophan + O2 = N-formyl-L-kynurenine

  Catalysed by ANPEP, LAP3, NPEPPS, SLC7A5 and 3 morecytosol, extracellular spaceOne of 2 routes

• (3S)-citramalyl-CoAReach from here →
  1. L-cysteinylglycine dipeptidase
  2. L-cysteine hydrogen-sulfide-lyase (deaminating
  3. (3S)-citramalyl-CoA = pyruvate + acetyl-CoA

  Catalysed by ANPEP, LAP3, NPEPPS, CTH and 1 morecytosol

• L-2-aminoadipateReach from here →
  1. gamma-glutamyltransferase (alanine)
  2. L-kynurenine + H2O = anthranilate + L-alanine + H(+)
  3. 2-oxoadipate + L-kynurenine = L-2-aminoadipate + kynurenate + H2O

  Catalysed by GGTLC3, GGT1, GGT5, GGTLC2 and 4 morecytosol

• (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoAReach from here →
  1. L-cysteinylglycine dipeptidase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate:CoA ligase (AMP-forming)

  Catalysed by ANPEP, LAP3, NPEPPS, NAGS and 2 morecytosol, mitochondrial matrix, endoplasmic reticulumOne of 3 routes

• 5-phospho-beta-D-ribosylamineReach from here →
  1. L-cysteinylglycine dipeptidase
  2. transport of cysteine and glutamine (cytosol to extracellular)
  3. phosphoribosyl pyrophosphate amidotransferase (glutamine)

  Catalysed by ANPEP, LAP3, NPEPPS, SLC3A2 and 3 morecytosol, extracellular spaceOne of 2 routes

• D-glucosamine 6-phosphateReach from here →
  1. L-cysteinylglycine dipeptidase
  2. transport of cysteine and glutamine (cytosol to extracellular)
  3. D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate

  Catalysed by ANPEP, LAP3, NPEPPS, SLC3A2 and 4 morecytosol, extracellular space

• L-methionine (S)-S-oxideReach from here →
  1. L-cysteinylglycine dipeptidase
  2. transport of cysteine and methionine (cytosol to extracellular)
  3. [thioredoxin]-disulfide + L-methionine + H2O = L-methionine (S)-S-oxide + [thioredoxin]-dithiol

  Catalysed by ANPEP, LAP3, NPEPPS, SLC7A5 and 1 morecytosol, extracellular space

• L-methionine (R)-S-oxideReach from here →
  1. L-cysteinylglycine dipeptidase
  2. transport of cysteine and methionine (cytosol to extracellular)
  3. [thioredoxin]-disulfide + L-methionine + H2O = L-methionine (R)-S-oxide + [thioredoxin]-dithiol

  Catalysed by ANPEP, LAP3, NPEPPS, SLC7A5 and 3 morecytosol, extracellular space

• 5-amino-2-oxopentanoateReach from here →
  1. L-cysteinylglycine dipeptidase
  2. L-cysteine hydrogen-sulfide-lyase (deaminating
  3. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine

  Catalysed by ANPEP, LAP3, NPEPPS, CTH and 1 morecytosolOne of 4 routes

• deoxycholoyl-CoAReach from here →
  1. L-cysteinylglycine dipeptidase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)

  Catalysed by ANPEP, LAP3, NPEPPS, NAGS and 2 morecytosol, mitochondrial matrixOne of 4 routes

• hyodeoxycholateReach from here →
  1. gamma-glutamyltransferase (alanine)
  2. transport of GSH and lithocholate (cytosol to extracellular)
  3. cytochrome P450 (lithocholate)

  Catalysed by GGTLC3, GGT1, GGT5, GGTLC2 and 5 morecytosol, extracellular space

• methylamineReach from here →
  1. L-cysteinylglycine dipeptidase
  2. N(omega)-methyl-L-arginine + glyoxylate = 5-(3-methylguanidino)-2-oxopentanoate + glycine
  3. N(omega)-methyl-L-arginine + H2O = L-citrulline + methylamine

  Catalysed by ANPEP, LAP3, NPEPPS, AGXT2 and 1 morecytosol

• monodehydro-L-ascorbate radicalReach from here →
  1. L-cysteinylglycine dipeptidase
  2. (9Z)-octadecenoyl-CoA + glycine = N-(9Z-octadecenoyl)glycine + CoA + H(+)
  3. N-(9Z-octadecenoyl)glycine + 2 L-ascorbate + O2 = N-(9Z-octadecenoyl)-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O

  Catalysed by ANPEP, LAP3, NPEPPS, GLYATL3 and 2 morecytosolOne of 25 routes

• (6R)-L-erythro-5,6,7,8-tetrahydrobiopterinReach from here →
  1. L-cysteinylglycine dipeptidase
  2. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  3. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine

  Catalysed by ANPEP, LAP3, NPEPPS, AADAT and 1 morecytosol

• pyridoxal 5'-phosphateReach from here →
  1. gamma-glutamyltransferase (alanine)
  2. L-selenocysteine selenide-lyase (L-alanine-forming)
  3. pyridoxine 5'-phosphate + O2 = pyridoxal 5'-phosphate + H2O2

  Catalysed by GGTLC3, GGT1, GGT5, GGTLC2 and 4 morecytosol

• an L-alpha-amino acidReach from here →
  1. gamma-glutamyltransferase (alanine)
  2. L-kynurenine + H2O = anthranilate + L-alanine + H(+)
  3. an L-alpha-amino acid(in) + L-kynurenine(out) = an L-alpha-amino acid(out) + L-kynurenine(in)

  Catalysed by GGTLC3, GGT1, GGT5, GGTLC2 and 4 morecytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• 4-aminobutanoateReach from here →
  1. L-cysteinylglycine dipeptidase
  2. transport of chloride and cysteine (cytosol to extracellular)
  3. transport of 4-aminobutyrate and chloride (cytosol to extracellular)

  Catalysed by ANPEP, LAP3, NPEPPS, SLC6A14 and 1 morecytosol, extracellular spaceOne of 4 routes

• 3-iodo-L-tyrosineReach from here →
  1. L-cysteinylglycine dipeptidase
  2. transport of cysteine and tyrosine (cytosol to extracellular)
  3. thyroid peroxidase (iodine)

  Catalysed by ANPEP, LAP3, NPEPPS, SLC7A5 and 1 morecytosol, extracellular spaceOne of 2 routes

• a 2,3-dehydroacyl-CoAReach from here →
  1. L-cysteinylglycine dipeptidase
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. a 2,3-saturated acyl-CoA + A = a 2,3-dehydroacyl-CoA + AH2

  Catalysed by ANPEP, LAP3, NPEPPS, MOCOS and 1 morecytosol

• estrone 3-sulfateReach from here →
  1. glutathione = L-cysteinylglycine + 5-oxo-L-proline
  2. 1-chloro-2,4-dinitrobenzene + glutathione = 2,4-dinitrophenyl-S-glutathione + chloride + H(+)
  3. transport of estrone 3-sulfate (cytosol to extracellular)

  Catalysed by CHAC2, CHAC1, PTGES, LANCL1 and 3 moreextracellular space, cytosolOne of 2 routes

• decanoyl-CoAReach from here →
  1. L-cysteinylglycine dipeptidase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. medium-chain acyl-CoA ligase (decanoic acid)

  Catalysed by ANPEP, LAP3, NPEPPS, NAGS and 6 morecytosol, mitochondrial matrixOne of 8 routes

• (2E)-hexadecenoyl-CoAReach from here →
  1. L-cysteinylglycine dipeptidase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. Carnitine O-Palmitoyltransferase

  Catalysed by ANPEP, LAP3, NPEPPS, NAGS and 3 morecytosol, mitochondrial matrixOne of 4 routes

• (9Z)-hexadecenoyl-CoAReach from here →
  1. L-cysteinylglycine dipeptidase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. long-chain-fatty-acid-CoA ligase (palmitolate)

  Catalysed by ANPEP, LAP3, NPEPPS, NAGS and 8 morecytosol, mitochondrial matrixOne of 11 routes

• Fe(II)-heme aReach from here →
  1. L-cysteinylglycine dipeptidase
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2

  Catalysed by ANPEP, LAP3, NPEPPS, MOCOS and 1 morecytosol

• (R)-4'-phosphopantetheineReach from here →
  1. L-cysteinylglycine dipeptidase
  2. (R)-4'-phosphopantothenate:L-cysteine ligase
  3. N-[(R)-4-phosphopantothenoyl]-L-cysteine + H(+) = (R)-4'-phosphopantetheine + CO2

  Catalysed by ANPEP, LAP3, NPEPPS, PPCS and 1 morecytosol

• (4R)-4-hydroxy-2-oxoglutarateReach from here →
  1. L-cysteinylglycine dipeptidase
  2. L-cysteine hydrogen-sulfide-lyase (deaminating
  3. (4R)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate

  Catalysed by ANPEP, LAP3, NPEPPS, CTH and 1 morecytosolOne of 2 routes

• 3-hydroxyisovaleryl-CoAReach from here →
  1. L-cysteinylglycine dipeptidase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. (3-Hydroxyisovalerylcoa->3-Hydroxyisovalerylcarnitine)

  Catalysed by ANPEP, LAP3, NPEPPS, NAGS and 2 morecytosol, mitochondrial matrix

• (3R,5S)-1-pyrroline-3-hydroxy-5-carboxylateReach from here →
  1. gamma-glutamyltransferase (alanine)
  2. Transport of Hydroxy-Proline
  3. trans-4-Hydroxy-L-proline:NAD+ 5-oxidoreductase

  Catalysed by GGTLC3, GGT1, GGT5, GGTLC2 and 6 morecytosol, extracellular spaceOne of 5 routes

• leukotriene D4Reach from here →
  1. L-cysteinylglycine dipeptidase
  2. leukotriene C4 hydrolysis
  3. leukotriene C4 + H2O = leukotriene D4 + L-glutamate

  Catalysed by ANPEP, LAP3, NPEPPS, GGT1 and 1 morecytosol

• CHEBI:63544Reach from here →
  1. L-cysteinylglycine dipeptidase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. long-chain-fatty-acid-CoA ligase (adrenic acid)

  Catalysed by ANPEP, LAP3, NPEPPS, NAGS and 8 morecytosol, mitochondrial matrixOne of 7 routes

• 18-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. gamma-glutamyltransferase (alanine)
  2. transport of arachidonate and GSH (cytosol to extracellular)
  3. cytochrome P450 (arachidonate)

  Catalysed by GGTLC3, GGT1, GGT5, GGTLC2 and 3 morecytosol, extracellular space, endoplasmic reticulumOne of 2 routes

• 3-demethylubiquinol-10Reach from here →
  1. glutathione = L-cysteinylglycine + 5-oxo-L-proline
  2. ubiquinone-10 + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + ubiquinol-10
  3. 3-demethylubiquinol-10 + S-adenosyl-L-methionine = ubiquinol-10 + S-adenosyl-L-homocysteine + H(+)

  Catalysed by CHAC2, CHAC1, SQOR, COQ3

• hexacosanoyl-CoAReach from here →
  1. L-cysteinylglycine dipeptidase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. long-chain-fatty-acid-CoA ligase (cerotic acid)

  Catalysed by ANPEP, LAP3, NPEPPS, NAGS and 8 morecytosol, mitochondrial matrixOne of 5 routes

• tetracosanoyl-CoAReach from here →
  1. L-cysteinylglycine dipeptidase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. long-chain-fatty-acid-CoA ligase (lignocerate)

  Catalysed by ANPEP, LAP3, NPEPPS, NAGS and 8 morecytosol, mitochondrial matrixOne of 10 routes

• docosanoyl-CoAReach from here →
  1. L-cysteinylglycine dipeptidase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. long-chain-fatty-acid-CoA ligase (behenic acid)

  Catalysed by ANPEP, LAP3, NPEPPS, NAGS and 8 morecytosol, mitochondrial matrixOne of 9 routes

• a 2,3-saturated acyl-CoAReach from here →
  1. gamma-glutamyltransferase (alanine)
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. a 2,3-saturated acyl-CoA + A = a 2,3-dehydroacyl-CoA + AH2

  Catalysed by GGTLC3, GGT1, GGT5, GGTLC2 and 4 morecytosol

• N(5)-[(Z)-amino(hydroxyimino)methyl]ornithineReach from here →
  1. L-cysteinylglycine dipeptidase
  2. transport of arginine and cysteine (cytosol to extracellular)
  3. L-arginine,NADPH:oxygen oxidoreductase (N-(omega)-hydroxyarginine-forming)

  Catalysed by ANPEP, LAP3, NPEPPS, SLC7A6 and 3 morecytosol, extracellular space

• xanthurenateReach from here →
  1. L-cysteinylglycine dipeptidase
  2. glycine + 2-oxoglutarate = glyoxylate + L-glutamate
  3. 3-hydroxy-L-kynurenine + glyoxylate = xanthurenate + glycine + H2O

  Catalysed by ANPEP, LAP3, NPEPPS, AADAT and 1 morecytosolOne of 2 routes

• (R)-adrenalineReach from here →
  1. gamma-glutamyltransferase (alanine)
  2. transport of GSH and noradrenaline (cytosol to extracellular)
  3. (R)-noradrenaline + S-adenosyl-L-methionine = (R)-adrenaline + S-adenosyl-L-homocysteine + H(+)

  Catalysed by GGTLC3, GGT1, GGT5, GGTLC2 and 5 morecytosol, extracellular space

• (2E)-octadecenoyl-CoAReach from here →
  1. L-cysteinylglycine dipeptidase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. Carnitine O-Palmitoyltransferase

  Catalysed by ANPEP, LAP3, NPEPPS, NAGS and 3 morecytosol, mitochondrial matrixOne of 3 routes

• (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoAReach from here →
  1. L-cysteinylglycine dipeptidase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. long-chain-fatty-acid-CoA ligase (stearidonic acid)

  Catalysed by ANPEP, LAP3, NPEPPS, NAGS and 8 morecytosol, mitochondrial matrixOne of 8 routes

• (4S)-4-hydroxy-2-oxoglutarateReach from here →
  1. L-cysteinylglycine dipeptidase
  2. L-cysteine hydrogen-sulfide-lyase (deaminating
  3. (4S)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate

  Catalysed by ANPEP, LAP3, NPEPPS, CTH and 1 morecytosolOne of 2 routes

• CHEBI:730073Reach from here →
  1. glutathione = L-cysteinylglycine + 5-oxo-L-proline
  2. urate(out) + glutathione(in) = urate(in) + glutathione(out)
  3. Peroxidase

  Catalysed by CHAC2, CHAC1, SLC22A13, MPOinner side of the membrane, outer side of the membrane, nucleusOne of 3 routes

• L-threonylcarbamoyladenylateReach from here →
  1. gamma-glutamyltransferase (alanine)
  2. L-threonine(out) + L-alanine(in) = L-threonine(in) + L-alanine(out)
  3. L-threonine + hydrogencarbonate + ATP = L-threonylcarbamoyladenylate + diphosphate + H2O

  Catalysed by GGTLC3, GGT1, GGT5, GGTLC2 and 4 morecytosol, inner side of the membrane, outer side of the membrane

• (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoAReach from here →
  1. L-cysteinylglycine dipeptidase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. long-chain-fatty-acid-CoA ligase (EPA)

  Catalysed by ANPEP, LAP3, NPEPPS, NAGS and 8 morecytosol, mitochondrial matrixOne of 9 routes

• (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoAReach from here →
  1. L-cysteinylglycine dipeptidase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. long-chain-fatty-acid-CoA ligase (DPA)

  Catalysed by ANPEP, LAP3, NPEPPS, NAGS and 8 morecytosol, mitochondrial matrixOne of 6 routes

• (9Z,12Z,15Z)-octadecatrienoyl-CoAReach from here →
  1. L-cysteinylglycine dipeptidase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. long-chain-fatty-acid-CoA ligase (linolenate)

  Catalysed by ANPEP, LAP3, NPEPPS, NAGS and 8 morecytosol, mitochondrial matrixOne of 7 routes

• (13Z)-docosenoyl-CoAReach from here →
  1. L-cysteinylglycine dipeptidase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. long-chain-fatty-acid-CoA ligase (cis-erucic acid)

  Catalysed by ANPEP, LAP3, NPEPPS, NAGS and 8 morecytosol, mitochondrial matrixOne of 6 routes