N-acetyl-D-glucosamine 6-phosphate

Three steps

• (5Z)-dodecenoyl-CoAReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. acetyl-CoA C-acyltransferase (3-oxomyrist-7-enoyl-CoA)

  Catalysed by CEMP1, AMDHD2, GNPNAT1, HADHA and 2 morecytosol, mitochondrial matrixOne of 2 routes

• (11Z)-docosenoyl-CoA(4-)Reach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (cis-cetoleic acid)

  Catalysed by CEMP1, AMDHD2, GNPNAT1, SLC27A2 and 7 morecytosolOne of 5 routes

• (7Z)-tetradecenoyl-CoAReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase ((7Z)-tetradecenoic acid)

  Catalysed by CEMP1, AMDHD2, GNPNAT1, SLC27A2 and 7 morecytosolOne of 8 routes

• (4Z,7Z,10Z,13Z)-hexadecatetraenoyl-CoAReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. Fatty Acid Beta Oxidation (C18:4->C16:4), Mitochondrial

  Catalysed by CEMP1, AMDHD2, GNPNAT1, HADHA and 2 morecytosol, mitochondrial matrixOne of 3 routes

• (7Z,10Z)-hexadecadienoyl-CoAReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. Fatty Acid Beta Oxidation Trans (C18:2->C16:2), Mitochondrial

  Catalysed by CEMP1, AMDHD2, GNPNAT1, HADHA and 2 morecytosol, mitochondrial matrix

• (4Z,7Z)-decadienoyl-CoAReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. Fatty Acid Beta Oxidation (C12:3->C10:2), Mitochondrial

  Catalysed by CEMP1, AMDHD2, GNPNAT1, ECHS1 and 2 morecytosol, mitochondrial matrixOne of 2 routes

• (5Z)-octenoyl-CoAReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. Fatty Acid Beta Oxidation (C10:2->C8:1), Mitochondrial

  Catalysed by CEMP1, AMDHD2, GNPNAT1, ECHS1 and 2 morecytosol, mitochondrial matrixOne of 2 routes

• an N-acetyl-alpha-D-glucosaminyl-(1->4)-beta-D-galactosyl derivativeReach from here →
  1. N-acetyl-alpha-D-glucosamine 1-phosphate = N-acetyl-D-glucosamine 6-phosphate
  2. N-acetyl-alpha-D-glucosamine 1-phosphate + UTP + H(+) = UDP-N-acetyl-alpha-D-glucosamine + diphosphate
  3. a beta-D-galactoside + UDP-N-acetyl-alpha-D-glucosamine = an N-acetyl-alpha-D-glucosaminyl-(1->4)-beta-D-galactosyl derivative + UDP + H(+)

  Catalysed by PGM3, UAP1, A4GNT

• CHEBI:27540Reach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. medium-chain acyl-CoA ligase (hexanoic acid)

  Catalysed by CEMP1, AMDHD2, GNPNAT1, ACSM4 and 5 morecytosolOne of 6 routes

• 17alpha,21-dihydroxypregnenoloneReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. cytochrome P450 (17alpha-hydroxypregnenolone)
  3. cytochrome P450

  Catalysed by CEMP1, AMDHD2, CYP17A1, CYP21A2cytosol, endoplasmic reticulum

• elaidic acidReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (elaidate)

  Catalysed by CEMP1, AMDHD2, GNPNAT1, SLC27A2 and 7 morecytosolOne of 5 routes

• 11-deoxycortisolReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. cytochrome P450 (17alpha-hydroxyprogesterone)
  3. cytochrome P450 (17alpha-hydroxyprogesterone)

  Catalysed by CEMP1, AMDHD2, CYP17A1, CYP21A2cytosol, endoplasmic reticulumOne of 3 routes

• 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholineReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
  3. 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine

  Catalysed by CEMP1, AMDHD2, ASAH1, PLA2G15cytosolOne of 3 routes

• 3beta-hydroxyandrost-5-en-17-oneReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. cytochrome P450 (17alpha-hydroxypregnenolone)
  3. cytochrome P450 (17alpha-hydroxypregnenolone)

  Catalysed by CEMP1, AMDHD2, CYP17A1cytosol, endoplasmic reticulumOne of 6 routes

• CHEBI:28701Reach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. Propanoyl-CoA:acetyl-CoA C-acyltransferase

  Catalysed by CEMP1, AMDHD2, GNPNAT1, ACAA1 and 2 morecytosol, peroxisomeOne of 7 routes

• CHEBI:29052Reach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. D-glucosamine-6-phosphate aminohydrolase (ketol isomerizing)
  3. sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase

  Catalysed by CEMP1, AMDHD2, GNPDA1, GNPDA2 and 1 morecytosol

• chlorine(.)Reach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. transport of acetate and formate (cytosol to extracellular)
  3. transport of chloride and formate (cytosol to extracellular)

  Catalysed by CEMP1, AMDHD2, SLC16A4, SLC16A5 and 2 morecytosol, extracellular spaceOne of 2 routes

• 3-hydroxypyruvic acidReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. L-Serine:pyruvate aminotransferase

  Catalysed by CEMP1, AMDHD2, SLC16A4, SLC16A5 and 4 morecytosol, extracellular spaceOne of 2 routes

• putrescineReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. N-acetylputrescine + H2O = putrescine + acetate
  3. N-acetylputrescine + H2O = putrescine + acetate

  Catalysed by CEMP1, AMDHD2, HDAC10cytosol

• beta-D-fructose 1,6-bisphosphateReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. alpha-D-glucosamine 6-phosphate + H2O = beta-D-fructose 6-phosphate + NH4(+)
  3. beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate

  Catalysed by CEMP1, AMDHD2, GNPDA1, GNPDA2 and 2 morecytosolOne of 2 routes

• 3-oxopropanoateReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. 3-oxopropanoate + L-alanine = beta-alanine + pyruvate

  Catalysed by CEMP1, AMDHD2, SLC16A4, SLC16A5 and 4 morecytosol, extracellular space

• a phenolReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. a phenyl acetate + H2O = a phenol + acetate + H(+)
  3. a phenyl acetate + H2O = a phenol + acetate + H(+)

  Catalysed by CEMP1, AMDHD2, PON1, PON2 and 1 morecytosol

• D-serineReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. D-serine = pyruvate + NH4(+)

  Catalysed by CEMP1, AMDHD2, SLC16A4, SLC16A5 and 4 morecytosol, extracellular space

• D-glucopyranose 6-phosphateReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. D-glucosamine-6-phosphate aminohydrolase (ketol isomerizing)
  3. D-glucose-6-phosphate aldose-ketose-isomerase

  Catalysed by CEMP1, AMDHD2, GNPDA1, GNPDA2 and 1 morecytosol

• (R)-lactic acidReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. (R)-Lactate:NAD+ oxidoreductase

  Catalysed by CEMP1, AMDHD2, SLC16A4, SLC16A5 and 4 morecytosol, extracellular space

• (3S)-3-hydroxy-3-methylglutaryl-CoAReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. transport of acetate and acetoacetate (cytosol to extracellular)
  3. (3S)-3-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA

  Catalysed by CEMP1, AMDHD2, SLC16A4, SLC16A5 and 5 morecytosol, extracellular space

• 2-iminopropanoateReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. 2-iminopropanoate + H2O = pyruvate + NH4(+)

  Catalysed by CEMP1, AMDHD2, SLC16A4, SLC16A5 and 4 morecytosol, extracellular space

• phosphoenolpyruvic acidReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. pyruvate kinase (dTDP)

  Catalysed by CEMP1, AMDHD2, SLC16A4, SLC16A5 and 5 morecytosol, extracellular space

• 13-cis-retinalReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. transport of acetate and retinoate (cytosol to extracellular)
  3. retinal dehydrogenase (13-cis-retinal)

  Catalysed by CEMP1, AMDHD2, SLC16A4, SLC16A5 and 3 morecytosol, extracellular space, endoplasmic reticulum

• N-acetyl-beta-neuraminic acidReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)

  Catalysed by CEMP1, AMDHD2, SLC16A4, SLC16A5 and 4 morecytosol, extracellular space

• L-ornithineReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. N2-Acetyl-L-ornithine amidohydrolase
  3. N2-Acetyl-L-ornithine amidohydrolase

  Catalysed by CEMP1, AMDHD2, ACY1cytosol

• taurineReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)

  Catalysed by CEMP1, AMDHD2, GNPNAT1, BAATcytosolOne of 2 routes

• a 6-(N-acetyl-alpha-D-glucosaminyl)-1-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositolReach from here →
  1. phosphoglucomutase (N-acetylglucosamine-6-phosphate)
  2. UDP-N-acetylglucosamine diphosphorylase (N-acetylglucosamine-1-phosphate)
  3. phosphatidylinositol N-acetylglucosaminyltransferase (PI pool)

  Catalysed by PGM3, UAP1, UAP1L1, PIGA and 6 morecytosol, endoplasmic reticulumOne of 3 routes

• a 3-acylpyruvateReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. a 3-acylpyruvate + H2O = a carboxylate + pyruvate + H(+)

  Catalysed by CEMP1, AMDHD2, SLC16A4, SLC16A5 and 4 morecytosol, extracellular space

• acetoacetyl-CoAReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. transport of acetate and acetoacetate (cytosol to extracellular)
  3. acetoacetate + ATP + CoA = acetoacetyl-CoA + AMP + diphosphate

  Catalysed by CEMP1, AMDHD2, SLC16A4, SLC16A5 and 4 morecytosol, extracellular spaceOne of 2 routes

• glycineReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. glycine N-acyltransferase (N-arachidonoylglycine)

  Catalysed by CEMP1, AMDHD2, GNPNAT1, GLYAT and 2 morecytosol, mitochondrial matrixOne of 10 routes

• (R)-methylmalonyl-CoAReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. aldehyde dehydrogenase (2-methyl-3-oxopropanoate)

  Catalysed by CEMP1, AMDHD2, GNPNAT1, ALDH6A1cytosol, mitochondrial matrixOne of 2 routes

• (S)-methylmalonyl-CoAReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. (S)-methylmalonyl-CoA hydrolase

  Catalysed by CEMP1, AMDHD2, GNPNAT1cytosol, mitochondrial matrix

• 3'-dephospho-CoAReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. acid phosphatase 2, lysosomal (CoA)

  Catalysed by CEMP1, AMDHD2, GNPNAT1, ACP2cytosol, lysosomeOne of 2 routes

• (2E)-dodecenoyl-CoAReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. (2E)-dodecenoyl-CoA formation

  Catalysed by CEMP1, AMDHD2, GNPNAT1cytosol, mitochondrial matrixOne of 3 routes

• 4,8,12-trimethyltridecanoyl-CoAReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. propanoyl-CoA C-acyltransferase (3-ketopristanoyl-CoA)

  Catalysed by CEMP1, AMDHD2, GNPNAT1, ACAA1 and 1 morecytosol, peroxisomeOne of 2 routes

• (6Z,9Z,12Z)-octadecatrienoyl-CoAReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (gamma-linolenate)

  Catalysed by CEMP1, AMDHD2, GNPNAT1, SLC27A2 and 7 morecytosolOne of 7 routes

• butanoyl-CoAReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. transport of acetate and butyrate (cytosol to extracellular)
  3. Butanoate:CoA ligase (AMP-forming)

  Catalysed by CEMP1, AMDHD2, SLC16A4, SLC16A5 and 8 morecytosol, extracellular spaceOne of 11 routes

• dodecanoyl-CoAReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (lauric acid)

  Catalysed by CEMP1, AMDHD2, GNPNAT1, SLC27A2 and 7 morecytosolOne of 9 routes

• glutaryl-CoAReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. Production of Glutaryl Carnitine

  Catalysed by CEMP1, AMDHD2, GNPNAT1, CPT1A and 2 morecytosolOne of 2 routes

• eicosanoyl-CoAReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (eicosanoate)

  Catalysed by CEMP1, AMDHD2, GNPNAT1, SLC27A2 and 7 morecytosolOne of 12 routes

• itaconyl-CoAReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. Itaconate:CoA ligase (GDP-forming)

  Catalysed by CEMP1, AMDHD2, GNPNAT1, SUCLG1 and 2 morecytosol, mitochondrial matrixOne of 2 routes

• (9Z,12Z)-octadecadienoyl-CoAReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)

  Catalysed by CEMP1, AMDHD2, GNPNAT1, SLC27A2 and 7 morecytosolOne of 13 routes

• tetradecanoyl-CoAReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (myristic acid)

  Catalysed by CEMP1, AMDHD2, GNPNAT1, SLC27A2 and 7 morecytosolOne of 11 routes

• octanoyl-CoAReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. Octanoyl-CoA:L-carnitine O-octanoyltransferase

  Catalysed by CEMP1, AMDHD2, GNPNAT1, CROTcytosol, mitochondrial matrixOne of 20 routes