octadecanoyl-CoA

Two steps

• L-methionineReach from here →
  1. Stearoyl-CoA hydrolase
  2. N-acetylglutamate synthase (N-acetylmethionine)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 2 morecytosol, mitochondrial matrix

• a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)Reach from here →
  1. acyl-CoA pool formation and breakdown
  2. a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA

  Catalysed by LCLAT1, MBOAT7cytosol

• a 1-acyl-sn-glycero-3-phosphateReach from here →
  1. acyl-CoA pool formation and breakdown
  2. sn-glycerol 3-phosphate + an acyl-CoA = a 1-acyl-sn-glycero-3-phosphate + CoA

  Catalysed by GPAT3, GPAT2, GPAT4, GPAMcytosol

• L-alanineReach from here →
  1. Stearoyl-CoA hydrolase
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 1 morecytosol, mitochondrial matrix

• L-asparagineReach from here →
  1. Stearoyl-CoA hydrolase
  2. N-acetylglutamate synthase (N-acetyl-L-asparagine)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 2 morecytosol, mitochondrial matrix

• L,L-cystathionineReach from here →
  1. Stearoyl-CoA hydrolase
  2. N-acetylglutamate synthase (N-acetyl-L-cystathionine)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 2 morecytosol, mitochondrial matrix

• a 1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholineReach from here →
  1. octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
  2. a 1-acyl-sn-glycero-3-phosphocholine + (9Z)-octadecenoyl-CoA = a 1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + CoA

  Catalysed by SCD, SCD5, LPCAT4

• 3-oxosphinganineReach from here →
  1. Beta Oxidation of Long Chain Fatty Acid
  2. Palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating)

  Catalysed by ACAA1, HSD17B4, EHHADH, ACOX1 and 3 moreperoxisome, cytosol

• 1-hexadecanoylglycerone 3-phosphateReach from here →
  1. Beta Oxidation of Long Chain Fatty Acid
  2. glyceronephosphate O-acyltransferase (DHAP)

  Catalysed by ACAA1, HSD17B4, EHHADH, ACOX1 and 1 moreperoxisome

• (3Z)-dodecenoyl-CoAReach from here →
  1. Stearoyl-CoA hydrolase
  2. acetyl-CoA C-acyltransferase (3-oxomyrist-5-enoyl-CoA)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 4 morecytosol, mitochondrial matrixOne of 3 routes

• a 1,2-diacyl-sn-glycero-3-phosphateReach from here →
  1. acyl-CoA pool formation and breakdown
  2. a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA

  Catalysed by AGPAT2, GPAT3, GPAT2, LCLAT1 and 9 morecytosol

• (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoAReach from here →
  1. Stearoyl-CoA hydrolase
  2. 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate:CoA ligase (AMP-forming)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 3 morecytosol, endoplasmic reticulumOne of 3 routes

• deoxycholoyl-CoAReach from here →
  1. Stearoyl-CoA hydrolase
  2. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 3 morecytosolOne of 4 routes

• decanoyl-CoAReach from here →
  1. Stearoyl-CoA hydrolase
  2. medium-chain acyl-CoA ligase (decanoic acid)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 7 morecytosolOne of 7 routes

• (2E)-hexadecenoyl-CoAReach from here →
  1. Stearoyl-CoA hydrolase
  2. Carnitine O-Palmitoyltransferase

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 4 morecytosolOne of 7 routes

• (9Z)-hexadecenoyl-CoAReach from here →
  1. stearoyl-CoA desaturase (N-C18:0CoA -> N-C18:1CoA)
  2. Fatty Acid Beta Oxidation (C18:1->C16:1), Mitochondrial

  Catalysed by SCD, HADHA, ACADVL, HADHBcytosol, mitochondrial matrixOne of 16 routes

• a cardiolipinReach from here →
  1. acyl-CoA pool formation and breakdown
  2. 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + an acyl-CoA = a cardiolipin + CoA

  Catalysed by HADHAcytosol

• 3-hydroxyisovaleryl-CoAReach from here →
  1. Stearoyl-CoA hydrolase
  2. (3-Hydroxyisovalerylcoa->3-Hydroxyisovalerylcarnitine)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 3 morecytosol

• an all-trans-retinyl esterReach from here →
  1. acyl-CoA pool formation and breakdown
  2. all-trans-retinol + an acyl-CoA = an all-trans-retinyl ester + CoA

  Catalysed by DGAT1, PNPLA4, AWAT2, DGAT2cytosol

• CHEBI:63544Reach from here →
  1. Stearoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (adrenic acid)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 9 morecytosolOne of 8 routes

• a 1,2-diacyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. acyl-CoA pool formation and breakdown
  2. a 1-acyl-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CoA

  Catalysed by LPCAT4, LPCAT3, MBOAT1, MBOAT2cytosol

• a triacyl-sn-glycerolReach from here →
  1. acyl-CoA pool formation and breakdown
  2. an acyl-CoA + a 1,2-diacyl-sn-glycerol = a triacyl-sn-glycerol + CoA

  Catalysed by DGAT1, MOGAT2, AWAT2, MOGAT3 and 2 morecytosol

• a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
  1. acyl-CoA pool formation and breakdown
  2. 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA

  Catalysed by LCLAT1, LPCAT1, GPAMcytosol

• 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphateReach from here →
  1. octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
  2. 1-hexadecanoyl-sn-glycero-3-phosphate + (9Z)-octadecenoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA

  Catalysed by SCD, SCD5, AGPAT2, GPAT3 and 7 more

• hexacosanoyl-CoAReach from here →
  1. Stearoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (cerotic acid)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 9 morecytosolOne of 6 routes

• tetracosanoyl-CoAReach from here →
  1. Stearoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (lignocerate)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 9 morecytosolOne of 11 routes

• docosanoyl-CoAReach from here →
  1. Stearoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (behenic acid)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 9 morecytosolOne of 10 routes

• N-(2-hydroxyoctadecanoyl)-sphinganineReach from here →
  1. octadecanoyl-CoA + 2-oxoglutarate + O2 = 2-hydroxyoctadecanoyl-CoA + succinate + CO2
  2. 2-hydroxyoctadecanoyl-CoA + sphinganine = N-(2-hydroxyoctadecanoyl)-sphinganine + CoA + H(+)

  Catalysed by PHYH, CERS1, CERS3

• 3-oxooctadecanoyl-CoAReach from here →
  1. Beta Oxidation of Long Chain Fatty Acid
  2. very-long-chain 3-oxoacyl-CoA synthase (malonyl-CoA)

  Catalysed by ACAA1, HSD17B4, EHHADH, ACOX1 and 7 moreperoxisome, cytosolOne of 2 routes

• (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoAReach from here →
  1. Stearoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (stearidonic acid)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 9 morecytosolOne of 9 routes

• 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol)Reach from here →
  1. octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
  2. 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + (9Z)-octadecenoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA

  Catalysed by SCD, SCD5, LCLAT1

• 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
  1. octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
  2. 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + (9Z)-octadecenoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA

  Catalysed by SCD, SCD5, LCLAT1, LPGAT1

• 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
  1. octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
  2. 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + (9Z)-octadecenoyl-CoA = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA

  Catalysed by SCD, SCD5, LPCAT4, LCLAT1

• 1-hexadecanoyl-sn-glycero-3-phosphocholineReach from here →
  1. octadecanoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + CoA
  2. 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O = octadecanoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)

  Catalysed by LPCAT3, PLAAT3

• 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholineReach from here →
  1. octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
  2. 1-hexadecanoyl-sn-glycero-3-phosphocholine + (9Z)-octadecenoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA

  Catalysed by SCD, SCD5, LPCAT3, MBOAT1 and 3 more

• 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamineReach from here →
  1. octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
  2. 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + (9Z)-octadecenoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA

  Catalysed by SCD, SCD5, MBOAT1, MBOAT2

• (9Z)-octadecen-1-olReach from here →
  1. octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
  2. (9Z)-octadecenoyl-CoA + 2 NADPH + 2 H(+) = (9Z)-octadecen-1-ol + 2 NADP(+) + CoA

  Catalysed by SCD, SCD5, FAR1

• 1-octadecanoyl-sn-glycero-3-phosphocholineReach from here →
  1. 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA
  2. 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphocholine

  Catalysed by LPGAT1, PLA2G15One of 7 routes

• (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoAReach from here →
  1. Stearoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (EPA)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 9 morecytosolOne of 10 routes

• (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoAReach from here →
  1. Stearoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (DPA)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 9 morecytosolOne of 7 routes

• 3-oxo-(11Z)-eicosenoyl-CoAReach from here →
  1. octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
  2. (9Z)-octadecenoyl-CoA + malonyl-CoA + H(+) = 3-oxo-(11Z)-eicosenoyl-CoA + CO2 + CoA

  Catalysed by SCD, SCD5, ELOVL7, ELOVL6 and 2 more

• (9Z,12Z,15Z)-octadecatrienoyl-CoAReach from here →
  1. Stearoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (linolenate)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 9 morecytosolOne of 8 routes

• (13Z)-docosenoyl-CoAReach from here →
  1. Stearoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (cis-erucic acid)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 9 morecytosolOne of 7 routes

• (11Z)-eicosenoyl-CoAReach from here →
  1. Stearoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (cis-gondoic acid)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 9 morecytosolOne of 8 routes

• (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoAReach from here →
  1. Stearoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase ((9Z,12Z,15Z,18Z,21Z)-TPA)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 9 morecytosolOne of 6 routes

• (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoAReach from here →
  1. Stearoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase ((6Z,9Z,12Z,15Z,18Z,21Z)-THA)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 9 morecytosolOne of 5 routes

• N-(9Z-octadecenoyl)-sphinganineReach from here →
  1. octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
  2. sphinganine + (9Z)-octadecenoyl-CoA = N-(9Z-octadecenoyl)-sphinganine + CoA + H(+)

  Catalysed by SCD, SCD5, CERS5, CERS2

• (15Z)-tetracosenoyl-CoAReach from here →
  1. Stearoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (nervonic acid)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 9 morecytosolOne of 7 routes

• (17Z)-hexacosenoyl-CoAReach from here →
  1. Stearoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (ximenic acid)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 9 morecytosolOne of 5 routes

• (8Z,11Z,14Z)-eicosatrienoyl-CoAReach from here →
  1. Stearoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (dihomo-gamma-linolenate)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 9 morecytosolOne of 6 routes