octadecanoyl-CoA

Two steps

• cholesteryl (7Z)-octadecenoateReach from here →
  1. stearoyl-CoA 9-desaturase (stearoyl-CoA)
  2. (7Z)-octadecenoyl-CoA + cholesterol = cholesteryl (7Z)-octadecenoate + CoA

  Catalysed by SCD, SCD5, SOAT1cytosol

• CHEBI:15345Reach from here →
  1. Stearoyl-CoA hydrolase
  2. Acetoacetate:CoA ligase (AMP-forming)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 2 morecytosolOne of 2 routes

• cholineReach from here →
  1. Stearoyl-CoA hydrolase
  2. Acetyl-CoA:choline O-acetyltransferase

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 2 morecytosol, nucleus

• CHEBI:15380Reach from here →
  1. Stearoyl-CoA hydrolase
  2. 5-aminolevulinate synthase (2-amino-3-oxoadipate)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 3 morecytosol, mitochondrial matrixOne of 8 routes

• CHEBI:15477Reach from here →
  1. Stearoyl-CoA hydrolase
  2. glycine N-acyltransferase (2-methylbutyryl-CoA)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 4 morecytosol, mitochondrial matrixOne of 2 routes

• 2-methylcrotonoyl-CoAReach from here →
  1. Stearoyl-CoA hydrolase
  2. Production of Tiglylcarnitine

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 3 morecytosolOne of 2 routes

• isobutyryl-CoAReach from here →
  1. Stearoyl-CoA hydrolase
  2. acetyl-CoA C-acyltransferase (3-oxo-4-methyl-pentanoyl-CoA)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 4 morecytosol, mitochondrial matrixOne of 3 routes

• 3-methylbut-2-enoyl-CoAReach from here →
  1. Stearoyl-CoA hydrolase
  2. glycine-N-acyltransferase (3-methylcrotonoylglycine)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 2 morecytosol, mitochondrial matrix

• isovaleryl-CoAReach from here →
  1. Stearoyl-CoA hydrolase
  2. glycine N-acyltransferase (isovalerylglycine)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 4 morecytosol, mitochondrial matrixOne of 3 routes

• arachidonoyl-CoAReach from here →
  1. Stearoyl-CoA hydrolase
  2. Arachidonate:CoA ligase (AMP-forming)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 9 morecytosolOne of 12 routes

• CHEBI:15519Reach from here →
  1. Stearoyl-CoA hydrolase
  2. propanoyl-CoA C-acyltransferase

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 4 morecytosol, peroxisomeOne of 2 routes

• phenylacetyl-CoAReach from here →
  1. Stearoyl-CoA hydrolase
  2. Phenylacetate:CoA ligase

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 1 morecytosolOne of 3 routes

• propionyl-CoAReach from here →
  1. Stearoyl-CoA hydrolase
  2. Propanoate:CoA ligase (AMP-forming)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 4 morecytosolOne of 43 routes

• 1-(10Z-heptadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamineReach from here →
  1. octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
  2. 1-(10Z-heptadecenoyl)-sn-glycero-3-phosphoethanolamine + (9Z)-octadecenoyl-CoA = 1-(10Z-heptadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA

  Catalysed by SCD, SCD5, MBOAT1

• CHEBI:15650Reach from here →
  1. Stearoyl-CoA hydrolase
  2. N-acetyl-LTE4 to leukotriene E4 conversion

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 33 morecytosolOne of 2 routes

• S-(9Z-octadecenoyl)-4'-phosphopantetheineReach from here →
  1. octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
  2. (9Z)-octadecenoyl-CoA + H2O = S-(9Z-octadecenoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)

  Catalysed by SCD, SCD5, FITM2

• CHEBI:15727Reach from here →
  1. Stearoyl-CoA hydrolase
  2. N-alpha-acetyltransferase 10, NatA catalytic subunit (acetylcarnosine)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 2 morecytosol

• CHEBI:15746Reach from here →
  1. Stearoyl-CoA hydrolase
  2. diamine N-acetyltransferase (N1-acetylspermine)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 3 morecytosolOne of 2 routes

• hexadecanoic acidReach from here →
  1. Beta Oxidation of Long Chain Fatty Acid
  2. Palmitoyl-CoA hydrolase

  Catalysed by ACAA1, HSD17B4, EHHADH, ACOX1 and 5 moreperoxisome, cytosolOne of 2 routes

• 1-acylglycerone 3-phosphateReach from here →
  1. acyl-CoA pool formation and breakdown
  2. Acyl-CoA:glycerone-phosphate O-acyltransferase

  Catalysed by GNPATcytosol

• phosphatidylethanolamineReach from here →
  1. acyl-CoA pool formation and breakdown
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphoethanolamine O-acyltransferase

  Catalysed by LPCAT4, LPCAT3, LPCAT2, LPCAT1 and 1 morecytosol

• 1,2-diacyl-sn-glycero-3-phosphocholine(1+)Reach from here →
  1. acyl-CoA pool formation and breakdown
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase

  Catalysed by LPCAT4, LPCAT3, LPCAT2, LPCAT1cytosol

• cholesterolReach from here →
  1. sphing-4-enine + octadecanoyl-CoA = N-octadecanoylsphing-4-enine + CoA + H(+)
  2. beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-octadecanoylsphing-4-enine

  Catalysed by CERS1, TLCD3B, CERS2, CERS4 and 1 more

• hexadecan-1-olReach from here →
  1. Beta Oxidation of Long Chain Fatty Acid
  2. formate dehydrogenase (palmitoyl-CoA)

  Catalysed by ACAA1, HSD17B4, EHHADH, ACOX1 and 2 moreperoxisome

• 11-cis-retinyl hexadecanoateReach from here →
  1. Beta Oxidation of Long Chain Fatty Acid
  2. Palmitoyl-CoA:retinol O-acyltransferase

  Catalysed by ACAA1, HSD17B4, EHHADH, ACOX1 and 5 moreperoxisome, cytosol

• 11-cis-retinolReach from here →
  1. Stearoyl-CoA hydrolase
  2. Palmitoyl-CoA:retinol O-acyltransferase

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 6 morecytosol

• phosphatidic acidReach from here →
  1. acyl-CoA pool formation and breakdown
  2. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 5 morecytosol, mitochondrial matrixOne of 7 routes

• (R)-carnitineReach from here →
  1. (R)-carnitine + octadecanoyl-CoA = O-octadecanoyl-(R)-carnitine + CoA
  2. (R)-carnitine + octadecanoyl-CoA = O-octadecanoyl-(R)-carnitine + CoA

  Catalysed by CPT2

• oxaloacetateReach from here →
  1. Stearoyl-CoA hydrolase
  2. ATP citrate lyase (citrate)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 2 morecytosol

• 1-acyl-sn-glycerol 3-phosphateReach from here →
  1. glycerol-3-phosphate 1-O-acyltransferase (sn-glycerol-3-phosphate)
  2. 1-acylglycerol-3P-LD-TG1 pool (liver tissue) formation

  Catalysed by GPAT3, GPAT2, GPAT4, GPAMcytosolOne of 9 routes

• a cholesterol esterReach from here →
  1. Acyl-CoA:cholesterol O-acyltransferase
  2. cholesterol-ester plasma pool to cholesterol-ester-10,13,16,19-docosa conversion

  Catalysed by SOAT2, SOAT1endoplasmic reticulumOne of 4 routes

• octadecanalReach from here →
  1. Stearoyl-CoA hydrolase
  2. octadecanal + NAD(+) + H2O = octadecanoate + NADH + 2 H(+)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 2 morecytosol

• anilineReach from here →
  1. Stearoyl-CoA hydrolase
  2. Acetyl-CoA:arylamine N-acetyltransferase

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 3 morecytosol

• CHEBI:17312Reach from here →
  1. Stearoyl-CoA hydrolase
  2. N1,N12-diacetylspermine to N1-acetylspermine conversion

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 1 morecytosolOne of 2 routes

• 1-(alk-1-enyl)-2-acyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. acyl-CoA pool formation and breakdown
  2. Acyl-CoA:1-alkenylglycerophosphoethanolamine O-acyltransferase

  Catalysed by LPCAT4, LPCAT3, LPCAT2, LPCAT1cytosol

• O-hexadecanoyl-(R)-carnitineReach from here →
  1. Beta Oxidation of Long Chain Fatty Acid
  2. palmitoyl-CoA:L-carnitine O-palmitoyltransferase

  Catalysed by ACAA1, HSD17B4, EHHADH, ACOX1 and 2 moreperoxisomeOne of 4 routes

• L-cysteineReach from here →
  1. Stearoyl-CoA hydrolase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 2 morecytosol, mitochondrial matrix

• (7Z,10Z,13Z)-hexadecatrienoyl-CoAReach from here →
  1. Stearoyl-CoA hydrolase
  2. Fatty Acid Beta Oxidation (C18:3->C16:3), Mitochondrial

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 4 morecytosol, mitochondrial matrix

• a 1,2-diacyl-sn-glycerolReach from here →
  1. acyl-CoA pool formation and breakdown
  2. a 2-acylglycerol + an acyl-CoA = a 1,2-diacyl-sn-glycerol + CoA

  Catalysed by MOGAT2, AWAT2, MOGAT1cytosol

• a triacylglycerolReach from here →
  1. acyl-CoA pool formation and breakdown
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase

  Catalysed by DGAT1, MOGAT2, MOGAT3, MOGAT1 and 1 morecytosol

• CHEBI:17927Reach from here →
  1. Stearoyl-CoA hydrolase
  2. N1,N8-diacetylspermidine to N1-acetylspermidine conversion

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 1 morecytosol

• 1-(9Z-octadecenoyl)-3-octadecanoyl-sn-glycerolReach from here →
  1. octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
  2. 3-octadecanoyl-sn-glycerol + (9Z)-octadecenoyl-CoA = 1-(9Z-octadecenoyl)-3-octadecanoyl-sn-glycerol + CoA

  Catalysed by SCD, SCD5, MOGAT1

• 1-octanoyl-3-(9Z-octadecenoyl)-glycerolReach from here →
  1. octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
  2. 1-octanoylglycerol + (9Z)-octadecenoyl-CoA = 1-octanoyl-3-(9Z-octadecenoyl)-glycerol + CoA

  Catalysed by SCD, SCD5, MOGAT2

• 1-dodecanoyl-3-(9Z-octadecenoyl)-glycerolReach from here →
  1. octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
  2. 1-dodecanoylglycerol + (9Z)-octadecenoyl-CoA = 1-dodecanoyl-3-(9Z-octadecenoyl)-glycerol + CoA

  Catalysed by SCD, SCD5, MOGAT2, MOGAT1

• 1-octadecanoyl-3-(9Z-octadecenoyl)-glycerolReach from here →
  1. octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
  2. 1-octadecanoylglycerol + (9Z)-octadecenoyl-CoA = 1-octadecanoyl-3-(9Z-octadecenoyl)-glycerol + CoA

  Catalysed by SCD, SCD5, MOGAT2, MOGAT1

• 1-(9Z,12Z,15Z-octadecatrienoyl)-3-(9Z-octadecenoyl)-glycerolReach from here →
  1. octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
  2. 1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol + (9Z)-octadecenoyl-CoA = 1-(9Z,12Z,15Z-octadecatrienoyl)-3-(9Z-octadecenoyl)-glycerol + CoA

  Catalysed by SCD, SCD5, MOGAT2, MOGAT1

• 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-3-(9Z-octadecenoyl)-glycerolReach from here →
  1. octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
  2. 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + (9Z)-octadecenoyl-CoA = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-3-(9Z-octadecenoyl)-glycerol + CoA

  Catalysed by SCD, SCD5, MOGAT2

• 1-tetradecanoyl-3-(9Z-octadecenoyl)-glycerolReach from here →
  1. octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
  2. 1-tetradecanoylglycerol + (9Z)-octadecenoyl-CoA = 1-tetradecanoyl-3-(9Z-octadecenoyl)-glycerol + CoA

  Catalysed by SCD, SCD5, MOGAT2

• 1-O-(9Z-octadecyl)-3-(9Z-octadecenoyl)-glycerolReach from here →
  1. octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
  2. 1-O-(9Z-octadecenyl)-glycerol + (9Z)-octadecenoyl-CoA = 1-O-(9Z-octadecyl)-3-(9Z-octadecenoyl)-glycerol + CoA

  Catalysed by SCD, SCD5, DGAT1, MOGAT2 and 4 more

• 1-decanoyl-3-(9Z-octadecenoyl)-glycerolReach from here →
  1. octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
  2. 1-decanoylglycerol + (9Z)-octadecenoyl-CoA = 1-decanoyl-3-(9Z-octadecenoyl)-glycerol + CoA

  Catalysed by SCD, SCD5, MOGAT2