butanoyl-CoA

Three steps

• N-octanoylglycineReach from here →
  1. carnitine O-palmitoyltransferase (butyryl-CoA)
  2. Octanoyl-CoA:L-carnitine O-octanoyltransferase
  3. octanoyl-CoA + glycine = N-octanoylglycine + CoA + H(+)

  Catalysed by CPT1A, CPT1C, CPT1B, CROT and 1 morecytosol, mitochondrial matrixOne of 2 routes

• N(1)-(5-phospho-beta-D-ribosyl)glycinamideReach from here →
  1. carnitine O-palmitoyltransferase (butyryl-CoA)
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. 5-phospho-beta-D-ribosylamine + glycine + ATP = N(1)-(5-phospho-beta-D-ribosyl)glycinamide + ADP + phosphate + H(+)

  Catalysed by CPT1A, CPT1C, CPT1B, GLYAT and 3 morecytosol, mitochondrial matrix

• L-cystine-bis-glycineReach from here →
  1. carnitine O-palmitoyltransferase (butyryl-CoA)
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. L-cystine-bis-glycine + 2 H2O = L-cystine + 2 glycine

  Catalysed by CPT1A, CPT1C, CPT1B, GLYAT and 4 morecytosol, mitochondrial matrix

• an N-octadecanoyl-sphingoid baseReach from here →
  1. carnitine O-palmitoyltransferase (butyryl-CoA)
  2. long-chain-fatty-acid-CoA ligase (stearate)
  3. a sphingoid base + octadecanoyl-CoA = an N-octadecanoyl-sphingoid base + CoA + H(+)

  Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 7 morecytosol

• glycyldehydrophenylalanineReach from here →
  1. carnitine O-palmitoyltransferase (butyryl-CoA)
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. glycyldehydrophenylalanine + H2O = 2,3-didehydrophenylalanine + glycine

  Catalysed by CPT1A, CPT1C, CPT1B, GLYAT and 3 morecytosol, mitochondrial matrix

• 8-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoateReach from here →
  1. transport of butyryl-CoA and L-carnitine (cytosol to mitochondria)
  2. Utilized Transport
  3. arachidonate to 8-peroxy-(5Z,9E,11Z,14Z)-eicosatetraenoate conversion

  Catalysed by SLC33A1, ESCO2, OXSMmitochondrial matrix, cytosol, endoplasmic reticulumOne of 2 routes

• N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-serineReach from here →
  1. transport of butyryl-CoA and L-carnitine (cytosol to mitochondria)
  2. Utilized Transport
  3. N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-serine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + L-serine

  Catalysed by SLC33A1, ESCO2, OXSM, FAAH and 1 moremitochondrial matrix, cytosol, endoplasmic reticulum

• an N-(fatty acyl)-glycineReach from here →
  1. carnitine O-palmitoyltransferase (butyryl-CoA)
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. a fatty acyl-CoA + glycine = an N-(fatty acyl)-glycine + CoA + H(+)

  Catalysed by CPT1A, CPT1C, CPT1B, GLYAT and 2 morecytosol, mitochondrial matrix

• 1-(10Z-heptadecenoyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamineReach from here →
  1. carnitine O-palmitoyltransferase (butyryl-CoA)
  2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)
  3. 1-(10Z-heptadecenoyl)-sn-glycero-3-phosphoethanolamine + (9Z,12Z)-octadecadienoyl-CoA = 1-(10Z-heptadecenoyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + CoA

  Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 8 morecytosol

• N-(9Z,12Z-octadecadienoyl)-glycineReach from here →
  1. carnitine O-palmitoyltransferase (butyryl-CoA)
  2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)
  3. (9Z,12Z)-octadecadienoyl-CoA + glycine = N-(9Z,12Z-octadecadienoyl)-glycine + CoA + H(+)

  Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 8 morecytosolOne of 2 routes

• cholesteryl (7Z)-octadecenoateReach from here →
  1. carnitine O-palmitoyltransferase (butyryl-CoA)
  2. carnitine O-palmitoyltransferase ((7Z)-octadecenoyl-CoA)
  3. (7Z)-octadecenoyl-CoA + cholesterol = cholesteryl (7Z)-octadecenoate + CoA

  Catalysed by CPT1A, CPT1C, CPT1B, SOAT1cytosol

• acetoneReach from here →
  1. Butyryl-CoA hydrolase
  2. transport of acetoacetate and butyrate (cytosol to extracellular)
  3. Acetoacetate carboxy-lyase (acetone-forming)

  Catalysed by ACOT12, SLC16A4, SLC16A5, SLC16A7 and 2 morecytosol, extracellular space, mitochondrial matrix

• acetylcholineReach from here →
  1. carnitine O-palmitoyltransferase (butyryl-CoA)
  2. Acetyl-CoA:choline O-acetyltransferase
  3. Acetyl-CoA:choline O-acetyltransferase

  Catalysed by CPT1A, CPT1C, CPT1B, CHATcytosol, nucleusOne of 3 routes

• acetylpyruvateReach from here →
  1. Butyryl-CoA hydrolase
  2. transport of butyrate and pyruvate (cytosol to extracellular)
  3. acetylpyruvate + H2O = acetate + pyruvate + H(+)

  Catalysed by ACOT12, SLC16A4, SLC16A5, SLC16A3 and 4 morecytosol, extracellular spaceOne of 2 routes

• CHEBI:15467Reach from here →
  1. carnitine O-palmitoyltransferase (butyryl-CoA)
  2. Acetoacetate:CoA ligase (AMP-forming)
  3. 3-hydroxy-3-methylglutaryl-CoA synthase (acetoacetyl-CoA)

  Catalysed by CPT1A, CPT1C, CPT1B, AACS and 1 morecytosolOne of 3 routes

• CHEBI:15570Reach from here →
  1. carnitine O-palmitoyltransferase (butyryl-CoA)
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. transport of D-alanine and glycine (cytosol to extracellular)

  Catalysed by CPT1A, CPT1C, CPT1B, GLYAT and 4 morecytosol, mitochondrial matrix, extracellular spaceOne of 3 routes

• (S)-malateReach from here →
  1. carnitine O-palmitoyltransferase (butyryl-CoA)
  2. ATP citrate lyase (citrate)
  3. transport of malate and OAA (cytosol to mitochondria)

  Catalysed by CPT1A, CPT1C, CPT1B, ACLYcytosol, mitochondrial matrixOne of 7 routes

• L-leucineReach from here →
  1. transport of butyryl-CoA and L-carnitine (cytosol to mitochondria)
  2. Carnitine Transport by Atb0
  3. transport of chloride and leucine (cytosol to extracellular)

  Catalysed by SLC33A1, ESCO2, OXSM, SLC6A14mitochondrial matrix, cytosol, extracellular spaceOne of 23 routes

• CHEBI:15611Reach from here →
  1. carnitine O-palmitoyltransferase (butyryl-CoA)
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. S-Adenosyl-L-methionine:glycine N-methyltransferase

  Catalysed by CPT1A, CPT1C, CPT1B, GLYAT and 3 morecytosol, mitochondrial matrix

• 12(S)-HPETEReach from here →
  1. transport of butyryl-CoA and L-carnitine (cytosol to mitochondria)
  2. Utilized Transport
  3. arachidonate:oxygen 12-oxidoreductase

  Catalysed by SLC33A1, ESCO2, OXSM, ALOX12mitochondrial matrix, cytosol, endoplasmic reticulumOne of 4 routes

• 15(S)-HPETEReach from here →
  1. transport of butyryl-CoA and L-carnitine (cytosol to mitochondria)
  2. Utilized Transport
  3. arachidonate:oxygen 15-oxidoreductase

  Catalysed by SLC33A1, ESCO2, OXSM, ALOX15B and 1 moremitochondrial matrix, cytosol, endoplasmic reticulumOne of 4 routes

• 5(S)-HPETEReach from here →
  1. transport of butyryl-CoA and L-carnitine (cytosol to mitochondria)
  2. Utilized Transport
  3. Arachidonate:oxygen 5-oxidoreductase

  Catalysed by SLC33A1, ESCO2, OXSM, ALOX5mitochondrial matrix, cytosol, endoplasmic reticulum

• 10-formyltetrahydrofolic acidReach from here →
  1. Butyryl-CoA hydrolase
  2. transport of butyrate and formate (cytosol to extracellular)
  3. Formate:tetrahydrofolate ligase (ADP-forming)

  Catalysed by ACOT12, SLC16A4, SLC16A5, MTHFD1cytosol, extracellular spaceOne of 2 routes

• CHEBI:15699Reach from here →
  1. carnitine O-palmitoyltransferase (butyryl-CoA)
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. transport of glycine and homoserine (cytosol to extracellular)

  Catalysed by CPT1A, CPT1C, CPT1B, GLYAT and 3 morecytosol, mitochondrial matrix, extracellular spaceOne of 17 routes

• betaine aldehydeReach from here →
  1. carnitine O-palmitoyltransferase (butyryl-CoA)
  2. Acetyl-CoA:choline O-acetyltransferase
  3. choline dehydrogenase (choline)

  Catalysed by CPT1A, CPT1C, CPT1B, CHAT and 1 morecytosol, nucleusOne of 3 routes

• trimethylenediamineReach from here →
  1. carnitine O-palmitoyltransferase (butyryl-CoA)
  2. diamine N-acetyltransferase (N1-acetylspermidine)
  3. deoxyhypusine synthase (1,3-diaminopropane)

  Catalysed by CPT1A, CPT1C, CPT1B, SAT1 and 2 morecytosolOne of 2 routes

• 1-acylglycerone 3-phosphateReach from here →
  1. carnitine O-palmitoyltransferase (butyryl-CoA)
  2. acyl-CoA:sphingosine N-acyltransferase
  3. Acyl-CoA:glycerone-phosphate O-acyltransferase

  Catalysed by CPT1A, CPT1C, CPT1B, ASAH1 and 4 morecytosol, Golgi apparatus

• CHEBI:15971Reach from here →
  1. transport of butyryl-CoA and L-carnitine (cytosol to mitochondria)
  2. Carnitine Transport by Atb0
  3. transport of chloride and histidine (cytosol to extracellular)

  Catalysed by SLC33A1, ESCO2, OXSM, SLC6A14mitochondrial matrix, cytosol, extracellular spaceOne of 12 routes

• phosphatidylethanolamineReach from here →
  1. carnitine O-palmitoyltransferase (butyryl-CoA)
  2. acyl-CoA:sphingosine N-acyltransferase
  3. Acyl-CoA:1-acyl-sn-glycero-3-phosphoethanolamine O-acyltransferase

  Catalysed by CPT1A, CPT1C, CPT1B, ASAH1 and 8 morecytosol, Golgi apparatus

• 11-cis-retinalReach from here →
  1. carnitine O-palmitoyltransferase (butyryl-CoA)
  2. Palmitoyl-CoA:retinol O-acyltransferase
  3. 11-cis-retinol:NAD+ oxidoreductase

  Catalysed by CPT1A, CPT1C, CPT1B, DGAT1 and 11 morecytosolOne of 4 routes

• 1,2-diacyl-sn-glycero-3-phosphocholine(1+)Reach from here →
  1. carnitine O-palmitoyltransferase (butyryl-CoA)
  2. acyl-CoA:sphingosine N-acyltransferase
  3. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase

  Catalysed by CPT1A, CPT1C, CPT1B, ASAH1 and 7 morecytosol, Golgi apparatus

• hexadecan-1-olReach from here →
  1. carnitine O-palmitoyltransferase (butyryl-CoA)
  2. Palmitate:CoA ligase (AMP-forming)
  3. formate dehydrogenase (palmitoyl-CoA)

  Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 9 morecytosol, peroxisome

• sulfateReach from here →
  1. transport of butyryl-CoA and L-carnitine (cytosol to mitochondria)
  2. Carnitine Transport by Atb0
  3. transport of chloride and sulfate (cytosol to extracellular)

  Catalysed by SLC33A1, ESCO2, OXSM, SLC6A14 and 1 moremitochondrial matrix, cytosol, extracellular spaceOne of 7 routes

• 11-cis-retinyl hexadecanoateReach from here →
  1. carnitine O-palmitoyltransferase (butyryl-CoA)
  2. Palmitate:CoA ligase (AMP-forming)
  3. Palmitoyl-CoA:retinol O-acyltransferase

  Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 12 morecytosolOne of 3 routes

• 2-methyl-3-oxopropanoic acidReach from here →
  1. Butyryl-CoA hydrolase
  2. transport of butyrate and pyruvate (cytosol to extracellular)
  3. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

  Catalysed by ACOT12, SLC16A4, SLC16A5, SLC16A3 and 4 morecytosol, extracellular space, mitochondrial matrix

• L-cystineReach from here →
  1. carnitine O-palmitoyltransferase (butyryl-CoA)
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. Transport of L-Cystine (L-Alanine antiport) by B0, +At Transporter

  Catalysed by CPT1A, CPT1C, CPT1B, SLC7A9 and 1 morecytosol, mitochondrial matrix, extracellular spaceOne of 5 routes

• (R)-3-aminoisobutyric acidReach from here →
  1. carnitine O-palmitoyltransferase (butyryl-CoA)
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

  Catalysed by CPT1A, CPT1C, CPT1B, AGXT2cytosol, mitochondrial matrix

• phosphatidic acidReach from here →
  1. carnitine O-palmitoyltransferase (butyryl-CoA)
  2. acyl-CoA:sphingosine N-acyltransferase
  3. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase

  Catalysed by CPT1A, CPT1C, CPT1B, ASAH1 and 12 morecytosol, Golgi apparatus, mitochondrial matrixOne of 7 routes

• (R)-carnitineReach from here →
  1. transport of butyryl-CoA and L-carnitine (cytosol to mitochondria)
  2. solute carrier (L-carnitine)
  3. O-octanoyl-(R)-carnitine(in) + (R)-carnitine(out) = O-octanoyl-(R)-carnitine(out) + (R)-carnitine(in)

  Catalysed by SLC33A1, ESCO2, OXSM, SLC25A20mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 8 routes

• L-citrullineReach from here →
  1. carnitine O-palmitoyltransferase (butyryl-CoA)
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. transport of citrulline and glycine (cytosol to extracellular)

  Catalysed by CPT1A, CPT1C, CPT1B, GLYAT and 5 morecytosol, mitochondrial matrix, extracellular spaceOne of 8 routes

• iodideReach from here →
  1. transport of butyryl-CoA and L-carnitine (cytosol to mitochondria)
  2. Carnitine Transport by Atb0
  3. transport of chloride and iodide (cytosol to extracellular)

  Catalysed by SLC33A1, ESCO2, OXSM, SLC6A14 and 1 moremitochondrial matrix, cytosol, extracellular space

• L-valineReach from here →
  1. transport of butyryl-CoA and L-carnitine (cytosol to mitochondria)
  2. Carnitine Transport by Atb0
  3. transport of chloride and valine (cytosol to extracellular)

  Catalysed by SLC33A1, ESCO2, OXSM, SLC6A14mitochondrial matrix, cytosol, extracellular spaceOne of 22 routes

• L-arginineReach from here →
  1. transport of butyryl-CoA and L-carnitine (cytosol to mitochondria)
  2. Carnitine Transport by Atb0
  3. transport of arginine and chloride (cytosol to extracellular)

  Catalysed by SLC33A1, ESCO2, OXSM, SLC6A14mitochondrial matrix, cytosol, extracellular spaceOne of 20 routes

• CHEBI:16523Reach from here →
  1. carnitine O-palmitoyltransferase (butyryl-CoA)
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. transport of D-serine and glycine (cytosol to extracellular)

  Catalysed by CPT1A, CPT1C, CPT1B, GLYAT and 4 morecytosol, mitochondrial matrix, extracellular spaceOne of 2 routes

• protein polypeptide chainReach from here →
  1. carnitine O-palmitoyltransferase (butyryl-CoA)
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. PROTEIN_BS

  Catalysed by CPT1A, CPT1C, CPT1B, GLYAT and 2 morecytosol, mitochondrial matrixOne of 5 routes

• N(2)-acetyl-L-ornithineReach from here →
  1. Butyryl-CoA hydrolase
  2. transport of acetate and butyrate (cytosol to extracellular)
  3. N2-Acetyl-L-ornithine amidohydrolase

  Catalysed by ACOT12, SLC16A4, SLC16A5, SLC16A7 and 2 morecytosol, extracellular space

• CHEBI:16633Reach from here →
  1. carnitine O-palmitoyltransferase (butyryl-CoA)
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. L-selenocysteine selenide-lyase (L-alanine-forming)

  Catalysed by CPT1A, CPT1C, CPT1B, SCLYcytosol, mitochondrial matrix

• Met-tRNA(Met)Reach from here →
  1. carnitine O-palmitoyltransferase (butyryl-CoA)
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. L-Methionine:tRNAMet ligase (AMP-forming)

  Catalysed by CPT1A, CPT1C, CPT1B, NAGS and 1 morecytosol, mitochondrial matrix

• (S)-lactateReach from here →
  1. Butyryl-CoA hydrolase
  2. transport of butyrate and pyruvate (cytosol to extracellular)
  3. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)

  Catalysed by ACOT12, SLC16A4, SLC16A5, SLC16A3 and 8 morecytosol, extracellular space

• 4-methylsulfanyl-2-oxobutanoateReach from here →
  1. carnitine O-palmitoyltransferase (butyryl-CoA)
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. glyoxylate + L-methionine = 4-methylsulfanyl-2-oxobutanoate + glycine

  Catalysed by CPT1A, CPT1C, CPT1B, NAGS and 1 morecytosol, mitochondrial matrix