deoxycholate

Three steps

• (4Z,7Z,10Z,13Z)-hexadecatetraenoyl-CoAReach from here →
  1. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)
  2. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)
  3. Fatty Acid Beta Oxidation (C18:4->C16:4), Mitochondrial

  Catalysed by SLC27A2, SLC27A5, BAAT, HADHA and 2 morecytosol, mitochondrial matrixOne of 3 routes

• (7Z,10Z)-hexadecadienoyl-CoAReach from here →
  1. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)
  2. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)
  3. Fatty Acid Beta Oxidation Trans (C18:2->C16:2), Mitochondrial

  Catalysed by SLC27A2, SLC27A5, BAAT, HADHA and 2 morecytosol, mitochondrial matrix

• (4Z,7Z)-decadienoyl-CoAReach from here →
  1. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)
  2. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)
  3. Fatty Acid Beta Oxidation (C12:3->C10:2), Mitochondrial

  Catalysed by SLC27A2, SLC27A5, BAAT, ECHS1 and 2 morecytosol, mitochondrial matrixOne of 2 routes

• (5Z)-octenoyl-CoAReach from here →
  1. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)
  2. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)
  3. Fatty Acid Beta Oxidation (C10:2->C8:1), Mitochondrial

  Catalysed by SLC27A2, SLC27A5, BAAT, ECHS1 and 2 morecytosol, mitochondrial matrixOne of 2 routes

• 3-(glutathion-S-yl)-4-hydroxynonanalReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. glycodeoxycholate(in) + glutathione(in) + ATP + H2O = glycodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)
  3. (E)-4-hydroxynon-2-enal + glutathione = 3-(glutathion-S-yl)-4-hydroxynonanal

  Catalysed by ABCC4, GSTP1cytosol, inner side of the membrane, outer side of the membrane

• CHEBI:240943Reach from here →
  1. Glycodeoxycholate amidohydrolase
  2. Glycodeoxycholate amidohydrolase
  3. glycine N-acyltransferase (2-methylbutyryl-CoA)

  Catalysed by GLYAT, GLYATL2, GLYATL1cytosol, mitochondrial matrix

• a quinolReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. glycodeoxycholate(in) + glutathione(in) + ATP + H2O = glycodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)
  3. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol

  Catalysed by ABCC4, SQORcytosol, inner side of the membrane, outer side of the membrane

• phenylacetylglycineReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. Glycodeoxycholate amidohydrolase
  3. phenylacetyl-CoA:glycine N-phenylacetyltransferase

  Catalysed by GLYATcytosolOne of 3 routes

• CHEBI:27540Reach from here →
  1. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)
  2. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)
  3. medium-chain acyl-CoA ligase (hexanoic acid)

  Catalysed by SLC27A2, SLC27A5, BAAT, ACSM4 and 5 morecytosolOne of 6 routes

• elaidic acidReach from here →
  1. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)
  2. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)
  3. long-chain-fatty-acid-CoA ligase (elaidate)

  Catalysed by SLC27A2, SLC27A5, BAAT, ACSL4 and 6 morecytosolOne of 5 routes

• CHEBI:28666Reach from here →
  1. Glycodeoxycholate amidohydrolase
  2. Glycodeoxycholate amidohydrolase
  3. LTD4 hydrolysis

  No catalyst recordedcytosol

• CHEBI:28701Reach from here →
  1. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)
  2. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)
  3. Propanoyl-CoA:acetyl-CoA C-acyltransferase

  Catalysed by SLC27A2, SLC27A5, BAAT, ACAA1 and 2 morecytosol, peroxisomeOne of 7 routes

• L-ascorbic acidReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. glycodeoxycholate(in) + glutathione(in) + ATP + H2O = glycodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)
  3. L-dehydroascorbate + 2 glutathione = glutathione disulfide + L-ascorbate

  Catalysed by ABCC4, CLIC1, GSTO1, GSTO2cytosol, inner side of the membrane, outer side of the membrane

• Gly-tRNA(Gly)Reach from here →
  1. Glycodeoxycholate amidohydrolase
  2. Glycodeoxycholate amidohydrolase
  3. glycine:tRNA(Gly) ligase (AMP-forming)

  Catalysed by GARS1cytosol

• chlorine(.)Reach from here →
  1. Glycodeoxycholate amidohydrolase
  2. Glycodeoxycholate amidohydrolase
  3. transport of chloride and glycine (cytosol to extracellular)

  Catalysed by SLC6A9, SLC6A14cytosol, extracellular spaceOne of 3 routes

• glycocholateReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. Glycodeoxycholate amidohydrolase
  3. bile acid-CoA: amino acid N-acyltransferase

  Catalysed by BAATcytosol, peroxisomeOne of 4 routes

• cholateReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. glycodeoxycholate(in) + glutathione(in) + ATP + H2O = glycodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)
  3. cholate(in) + glutathione(in) + ATP + H2O = cholate(out) + glutathione(out) + ADP + phosphate + H(+)

  Catalysed by ABCC4cytosol, inner side of the membrane, outer side of the membrane

• hydrogen sulfideReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. glycodeoxycholate(in) + glutathione(in) + ATP + H2O = glycodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)
  3. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)

  Catalysed by ABCC4, TSTD1cytosol, inner side of the membrane, outer side of the membrane

• an alcoholReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. glycodeoxycholate(in) + glutathione(in) + ATP + H2O = glycodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)
  3. a hydroperoxide + 2 glutathione = an alcohol + glutathione disulfide + H2O

  Catalysed by ABCC4, CP, PRDX6cytosol, inner side of the membrane, outer side of the membrane

• 5-aminolevulinateReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. Glycodeoxycholate amidohydrolase
  3. succinyl-CoA + glycine + H(+) = 5-aminolevulinate + CO2 + CoA

  Catalysed by ALAS1, ALAS2cytosol

• glycochenodeoxycholateReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. Glycodeoxycholate amidohydrolase
  3. chenodeoxycholoyl-CoA + glycine = glycochenodeoxycholate + CoA + H(+)

  Catalysed by BAATcytosolOne of 2 routes

• taurocholateReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. glycodeoxycholate(in) + glutathione(in) + ATP + H2O = glycodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)
  3. taurocholate(in) + glutathione(in) + ATP + H2O = taurocholate(out) + glutathione(out) + ADP + phosphate + H(+)

  Catalysed by ABCC4cytosol, inner side of the membrane, outer side of the membrane

• glycochenodeoxycholic acidReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. Glycodeoxycholate amidohydrolase
  3. bile acid-CoA: amino acid N-acyltransferase

  Catalysed by BAATcytosol, peroxisomeOne of 3 routes

• glyoxylateReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. Glycodeoxycholate amidohydrolase
  3. glycine + 2-oxoglutarate = glyoxylate + L-glutamate

  Catalysed by AADATcytosolOne of 11 routes

• glycolithocholic acidReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. Glycodeoxycholate amidohydrolase
  3. bile acid-CoA:amino acid N-acyltransferase (glycine)

  Catalysed by BAATcytosolOne of 2 routes

• L-2-amino-3-oxobutanoic acidReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. Glycodeoxycholate amidohydrolase
  3. Acetyl-CoA:glycine C-acetyltransferase

  Catalysed by GCATcytosol, mitochondrial matrix

• tert-butanolReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. glycodeoxycholate(in) + glutathione(in) + ATP + H2O = glycodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)
  3. tert-butyl hydroperoxide + 2 glutathione = tert-butanol + glutathione disulfide + H2O

  Catalysed by ABCC4, CLIC2, GPX1, GPX2 and 2 morecytosol, inner side of the membrane, outer side of the membrane

• L-ornithineReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. Glycodeoxycholate amidohydrolase
  3. L-Arginine:glycine amidinotransferase

  Catalysed by GATMcytosolOne of 5 routes

• S(8)-aminomethyldihydrolipoamideReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. Glycodeoxycholate amidohydrolase
  3. dihydrolipoyl dehydrogenase ([protein]-N6-(lipoyl)lysine)

  Catalysed by GLDC, GCSHcytosol, mitochondrial matrix

• taurineReach from here →
  1. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)
  2. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)
  3. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)

  Catalysed by SLC27A2, SLC27A5, BAATcytosolOne of 4 routes

• (R)-methylmalonyl-CoAReach from here →
  1. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)
  2. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)
  3. aldehyde dehydrogenase (2-methyl-3-oxopropanoate)

  Catalysed by SLC27A2, SLC27A5, BAAT, ALDH6A1cytosol, mitochondrial matrixOne of 2 routes

• (S)-methylmalonyl-CoAReach from here →
  1. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)
  2. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)
  3. (S)-methylmalonyl-CoA hydrolase

  Catalysed by SLC27A2, SLC27A5, BAATcytosol, mitochondrial matrix

• 3'-dephospho-CoAReach from here →
  1. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)
  2. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)
  3. acid phosphatase 2, lysosomal (CoA)

  Catalysed by SLC27A2, SLC27A5, BAAT, ACP2cytosol, lysosomeOne of 2 routes

• (2E)-dodecenoyl-CoAReach from here →
  1. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)
  2. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)
  3. (2E)-dodecenoyl-CoA formation

  Catalysed by SLC27A2, SLC27A5, BAATcytosol, mitochondrial matrixOne of 3 routes

• 4,8,12-trimethyltridecanoyl-CoAReach from here →
  1. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)
  2. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)
  3. propanoyl-CoA C-acyltransferase (3-ketopristanoyl-CoA)

  Catalysed by SLC27A2, SLC27A5, BAAT, ACAA1 and 1 morecytosol, peroxisomeOne of 2 routes

• (6Z,9Z,12Z)-octadecatrienoyl-CoAReach from here →
  1. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)
  2. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)
  3. long-chain-fatty-acid-CoA ligase (gamma-linolenate)

  Catalysed by SLC27A2, SLC27A5, BAAT, ACSL4 and 6 morecytosolOne of 7 routes

• butanoyl-CoAReach from here →
  1. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)
  2. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)
  3. Butanoate:CoA ligase (AMP-forming)

  Catalysed by SLC27A2, SLC27A5, BAAT, ACSM4 and 5 morecytosolOne of 9 routes

• dodecanoyl-CoAReach from here →
  1. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)
  2. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)
  3. long-chain-fatty-acid-CoA ligase (lauric acid)

  Catalysed by SLC27A2, SLC27A5, BAAT, ACSL4 and 6 morecytosolOne of 9 routes

• glutaryl-CoAReach from here →
  1. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)
  2. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)
  3. Production of Glutaryl Carnitine

  Catalysed by SLC27A2, SLC27A5, BAAT, CPT1A and 2 morecytosolOne of 2 routes

• eicosanoyl-CoAReach from here →
  1. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)
  2. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)
  3. long-chain-fatty-acid-CoA ligase (eicosanoate)

  Catalysed by SLC27A2, SLC27A5, BAAT, ACSL4 and 6 morecytosolOne of 12 routes

• itaconyl-CoAReach from here →
  1. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)
  2. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)
  3. Itaconate:CoA ligase (GDP-forming)

  Catalysed by SLC27A2, SLC27A5, BAAT, SUCLG1 and 2 morecytosol, mitochondrial matrixOne of 2 routes

• (9Z,12Z)-octadecadienoyl-CoAReach from here →
  1. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)
  2. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)
  3. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)

  Catalysed by SLC27A2, SLC27A5, BAAT, ACSL4 and 6 morecytosolOne of 13 routes

• tetradecanoyl-CoAReach from here →
  1. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)
  2. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)
  3. long-chain-fatty-acid-CoA ligase (myristic acid)

  Catalysed by SLC27A2, SLC27A5, BAAT, ACSL4 and 6 morecytosolOne of 11 routes

• octanoyl-CoAReach from here →
  1. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)
  2. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)
  3. Octanoyl-CoA:L-carnitine O-octanoyltransferase

  Catalysed by SLC27A2, SLC27A5, BAAT, CROTcytosol, mitochondrial matrixOne of 20 routes

• phytanoyl-CoAReach from here →
  1. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)
  2. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)
  3. phytanate-CoA ligase

  Catalysed by SLC27A2, SLC27A5, BAATcytosolOne of 5 routes

• octadecanoyl-CoAReach from here →
  1. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)
  2. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)
  3. long-chain-fatty-acid-CoA ligase (stearate)

  Catalysed by SLC27A2, SLC27A5, BAAT, ACSL4 and 5 morecytosolOne of 15 routes

• (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. glycodeoxycholate(in) + glutathione(in) + ATP + H2O = glycodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)
  3. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + 2 glutathione = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + glutathione disulfide + H2O

  Catalysed by ABCC4, GPX1, GPX2, GPX4cytosol, inner side of the membrane, outer side of the membrane

• sarcosineReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. Glycodeoxycholate amidohydrolase
  3. sarcosine + O2 + H2O = formaldehyde + glycine + H2O2

  Catalysed by PIPOXcytosolOne of 2 routes

• (6S)-5,6,7,8-tetrahydrofolateReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. Glycodeoxycholate amidohydrolase
  3. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine

  Catalysed by SHMT1, SHMT2cytosol

• (R)-S-lactoylglutathioneReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. glycodeoxycholate(in) + glutathione(in) + ATP + H2O = glycodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)
  3. (R)-S-lactoylglutathione = methylglyoxal + glutathione

  Catalysed by ABCC4, GLO1cytosol, inner side of the membrane, outer side of the membrane