(6S)-5-methyl-5,6,7,8-tetrahydrofolate

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

391 compounds within 3 steps: 3 in 1, 42 in 2, 346 in 3

Three steps

AReach from here →
1. (6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine
2. transport of cysteine and methionine (cytosol to extracellular)
3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
Catalysed by MTR, SLC7A5, MOCOSextracellular space, cytosolOne of 71 routes
glycoursodeoxycholateReach from here →
1. (6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine
2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
3. glycine to glycoursodeoxycholate conversion
Catalysed by MTR, SHMT1, SHMT2cytosolOne of 2 routes
(18S)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoateReach from here →
1. (6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine
2. N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)
3. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (18S)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + A + H2O
Catalysed by MTR, CDKAL1, PTGS2
(15S)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoateReach from here →
1. (6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine
2. N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)
3. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (15S)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + A + H2O
Catalysed by MTR, CDKAL1, PTGS2
prostaglandin H3Reach from here →
1. (6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine
2. N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)
3. prostaglandin G3 + AH2 = prostaglandin H3 + A + H2O
Catalysed by MTR, CDKAL1, PTGS2
13-hydroxy-(9Z,11E)-octadecadienoateReach from here →
1. (6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine
2. N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)
3. (9Z,12Z)-octadecadienoate + AH2 + O2 = 13-hydroxy-(9Z,11E)-octadecadienoate + A + H2O
Catalysed by MTR, CDKAL1, PTGS2
9-hydroxy-(10E,12Z)-octadecadienoateReach from here →
1. (6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine
2. N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)
3. (9Z,12Z)-octadecadienoate + AH2 + O2 = 9-hydroxy-(10E,12Z)-octadecadienoate + A + H2O
Catalysed by MTR, CDKAL1, PTGS2
N-(9Z-octadecenoyl)glycineReach from here →
1. (6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine
2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
3. (9Z)-octadecenoyl-CoA + glycine = N-(9Z-octadecenoyl)glycine + CoA + H(+)
Catalysed by MTR, SHMT1, SHMT2, GLYATL3 and 1 more
N-(9Z-octadecenoyl)-L-phenylalanineReach from here →
1. (6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine
2. transport of methionine and phenylalanine (cytosol to extracellular)
3. L-phenylalanine + (9Z)-octadecenoate = N-(9Z-octadecenoyl)-L-phenylalanine + H2O
Catalysed by MTR, SLC7A5, PM20D1extracellular space, cytosol
N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanineReach from here →
1. (6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine
2. transport of methionine and phenylalanine (cytosol to extracellular)
3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + L-phenylalanine = N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanine + H2O
Catalysed by MTR, SLC7A5, PM20D1extracellular space, cytosol
N-(9Z-octadecenoyl)-L-leucineReach from here →
1. (6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine
2. transport of leucine and methionine (cytosol to extracellular)
3. N-(9Z-octadecenoyl)-L-leucine + H2O = L-leucine + (9Z)-octadecenoate
Catalysed by MTR, SLC3A2, SLC7A5, PM20D1extracellular space, cytosol
N-octadecanoylglycineReach from here →
1. (6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine
2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
3. octadecanoyl-CoA + glycine = N-octadecanoylglycine + CoA + H(+)
Catalysed by MTR, SHMT1, SHMT2, GLYATL2
N-(9Z-hexadecenoyl)-glycineReach from here →
1. (6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine
2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
3. (9Z)-hexadecenoyl-CoA + glycine = N-(9Z-hexadecenoyl)-glycine + CoA + H(+)
Catalysed by MTR, SHMT1, SHMT2, GLYATL2
(13R)-hydroxy-(9Z,11E)-octadecadienoateReach from here →
1. (6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine
2. N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)
3. (9Z,12Z)-octadecadienoate + AH2 + O2 = (13R)-hydroxy-(9Z,11E)-octadecadienoate + A + H2O
Catalysed by MTR, CDKAL1, PTGS1, PTGS2
2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphocholineReach from here →
1. (6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine
2. N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)
3. 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 = 2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O
Catalysed by MTR, CDKAL1, PTGS2
2-[(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholineReach from here →
1. (6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine
2. N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)
3. 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 = 2-[(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O
Catalysed by MTR, CDKAL1, PTGS2
2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholineReach from here →
1. (6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine
2. N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)
3. 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 = 2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O
Catalysed by MTR, CDKAL1, PTGS2
2-(prostaglandin H2)-sn-glycero-3-phosphoethanolamineReach from here →
1. (6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine
2. N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)
3. 2-(prostaglandin G2)-sn-glycero-3-phosphoethanolamine + AH2 = 2-(prostaglandin H2)-sn-glycero-3-phosphoethanolamine + A + H2O
Catalysed by MTR, CDKAL1, PTGS2
2-(prostaglandin H2)-sn-glycero-3-phosphocholineReach from here →
1. (6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine
2. N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)
3. 2-(prostaglandin G2)-sn-glycero-3-phosphocholine + AH2 = 2-(prostaglandin H2)-sn-glycero-3-phosphocholine + A + H2O
Catalysed by MTR, CDKAL1, PTGS2
N-hexadecanoylglycineReach from here →
1. (6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine
2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
3. hexadecanoyl-CoA + glycine = N-hexadecanoylglycine + CoA + H(+)
Catalysed by MTR, SHMT1, SHMT2, GLYATL3
N-dodecanoylglycineReach from here →
1. (6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine
2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
3. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
Catalysed by MTR, SHMT1, SHMT2, GLYATL2
N-decanoylglycineReach from here →
1. (6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine
2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
3. decanoyl-CoA + glycine = N-decanoylglycine + CoA + H(+)
Catalysed by MTR, SHMT1, SHMT2, GLYATL2
N-octanoylglycineReach from here →
1. (6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine
2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
3. octanoyl-CoA + glycine = N-octanoylglycine + CoA + H(+)
Catalysed by MTR, SHMT1, SHMT2, GLYATL2
D-histidineReach from here →
1. (6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine
2. transport of methionine and ornithine (cytosol to extracellular)
3. D-histidine(in) + L-ornithine(out) + H(+)(in) = D-histidine(out) + L-ornithine(in) + H(+)(out)
Catalysed by MTR, SLC7A6, SLC25A2extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes
L-homoarginineReach from here →
1. (6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine
2. transport of arginine and methionine (cytosol to extracellular)
3. L-homoarginine(in) + L-arginine(out) = L-homoarginine(out) + L-arginine(in)
Catalysed by MTR, SLC7A6, SLC25A29extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 4 routes
L-homocarnosineReach from here →
1. (6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine
2. transport of histidine and methionine (cytosol to extracellular)
3. Formation of homocarnosine
Catalysed by MTR, SLC7A6, CARNS1extracellular space, cytosol
N(1)-(5-phospho-beta-D-ribosyl)glycinamideReach from here →
1. (6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine
2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
3. 5-phospho-beta-D-ribosylamine + glycine + ATP = N(1)-(5-phospho-beta-D-ribosyl)glycinamide + ADP + phosphate + H(+)
Catalysed by MTR, SHMT1, SHMT2, GART
L-cystine-bis-glycineReach from here →
1. (6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine
2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
3. L-cystine-bis-glycine + 2 H2O = L-cystine + 2 glycine
Catalysed by MTR, SHMT1, SHMT2, DPEP1 and 1 more
glycyldehydrophenylalanineReach from here →
1. (6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine
2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
3. glycyldehydrophenylalanine + H2O = 2,3-didehydrophenylalanine + glycine
Catalysed by MTR, SHMT1, SHMT2, DPEP1
N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamideReach from here →
1. (6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine
2. (6S)-5,6,7,8-tetrahydrofolate + formate + ATP = (6R)-10-formyltetrahydrofolate + ADP + phosphate
3. N(1)-(5-phospho-beta-D-ribosyl)glycinamide + (6R)-10-formyltetrahydrofolate = N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + (6S)-5,6,7,8-tetrahydrofolate + H(+)
Catalysed by MTR, MTHFD1, MTHFD1L, GART
2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidineReach from here →
1. (6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine
2. transport of glutamine and methionine (cytosol to extracellular)
3. N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + L-glutamine + ATP + H2O = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + L-glutamate + ADP + phosphate + H(+)
Catalysed by MTR, SLC7A5, PFASextracellular space, cytosol
kinetensinReach from here →
1. (6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine
2. transport of methionine and phenylalanine (cytosol to extracellular)
3. Chymase
Catalysed by MTR, SLC7A5, CMA1extracellular space, cytosolOne of 3 routes
an N-(fatty acyl)-glycineReach from here →
1. (6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine
2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
3. a fatty acyl-CoA + glycine = an N-(fatty acyl)-glycine + CoA + H(+)
Catalysed by MTR, SHMT1, SHMT2, GLYATL2
N-(9Z,12Z-octadecadienoyl)-glycineReach from here →
1. (6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine
2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
3. (9Z,12Z)-octadecadienoyl-CoA + glycine = N-(9Z,12Z-octadecadienoyl)-glycine + CoA + H(+)
Catalysed by MTR, SHMT1, SHMT2, GLYATL2
(7Z)-octadecenoyl-CoAReach from here →
1. (6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine
2. N-acetylglutamate synthase (N-acetylmethionine)
3. carnitine O-palmitoyltransferase ((7Z)-octadecenoyl-CoA)
Catalysed by MTR, NAGS, CPT1A, CPT1C and 1 moremitochondrial matrix, cytosolOne of 3 routes
acetaldehydeReach from here →
1. (6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine
2. transport of methionine and threonine (cytosol to extracellular)
3. L-threonine acetaldehyde-lyase (glycine-forming)
Catalysed by MTR, SLC7A5extracellular space, cytosol
CHEBI:15345Reach from here →
1. (6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine
2. N-acetylglutamate synthase (N-acetylmethionine)
3. Acetoacetate:CoA ligase (AMP-forming)
Catalysed by MTR, NAGS, AACSmitochondrial matrix, cytosolOne of 2 routes
cholineReach from here →
1. (6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine
2. N-acetylglutamate synthase (N-acetylmethionine)
3. Acetyl-CoA:choline O-acetyltransferase
Catalysed by MTR, NAGS, CHATmitochondrial matrix, nucleusOne of 2 routes
pyruvateReach from here →
1. (6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine
2. transport of alanine and methionine (cytosol to extracellular)
3. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
Catalysed by MTR, SLC7A5, AGXT2extracellular space, cytosol, mitochondrial matrixOne of 16 routes
4a-hydroxytetrahydrobiopterinReach from here →
1. (6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine
2. transport of methionine and tryptophan (cytosol to extracellular)
3. L-tryptophan,tetrahydrobiopterin:oxygen oxidoreductase(5-hydroxylating)
Catalysed by MTR, SLC7A5, TPH1, TPH2extracellular space, cytosolOne of 3 routes
CHEBI:15380Reach from here →
1. (6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine
2. N-acetylglutamate synthase (N-acetylmethionine)
3. 5-aminolevulinate synthase (2-amino-3-oxoadipate)
Catalysed by MTR, NAGS, ALAS1, CPNE7mitochondrial matrixOne of 8 routes
CHEBI:15477Reach from here →
1. (6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine
2. N-acetylglutamate synthase (N-acetylmethionine)
3. glycine N-acyltransferase (2-methylbutyryl-CoA)
Catalysed by MTR, NAGS, GLYAT, GLYATL2 and 1 moremitochondrial matrixOne of 2 routes
2-methylcrotonoyl-CoAReach from here →
1. (6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine
2. N-acetylglutamate synthase (N-acetylmethionine)
3. Production of Tiglylcarnitine
Catalysed by MTR, NAGS, CPT1A, CPT1Bmitochondrial matrix, cytosolOne of 2 routes
isobutyryl-CoAReach from here →
1. (6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine
2. N-acetylglutamate synthase (N-acetylmethionine)
3. acetyl-CoA C-acyltransferase (3-oxo-4-methyl-pentanoyl-CoA)
Catalysed by MTR, NAGS, HADHA, ACAA2 and 1 moremitochondrial matrixOne of 3 routes
3-methylbut-2-enoyl-CoAReach from here →
1. (6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine
2. N-acetylglutamate synthase (N-acetylmethionine)
3. glycine-N-acyltransferase (3-methylcrotonoylglycine)
Catalysed by MTR, NAGS, GLYATmitochondrial matrix
isovaleryl-CoAReach from here →
1. (6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine
2. N-acetylglutamate synthase (N-acetylmethionine)
3. glycine N-acyltransferase (isovalerylglycine)
Catalysed by MTR, NAGS, GLYAT, GLYATL2 and 1 moremitochondrial matrixOne of 3 routes
arachidonoyl-CoAReach from here →
1. (6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine
2. N-acetylglutamate synthase (N-acetylmethionine)
3. Arachidonate:CoA ligase (AMP-forming)
Catalysed by MTR, NAGS, SLC27A2, ACSL4 and 6 moremitochondrial matrix, cytosolOne of 11 routes
CHEBI:15519Reach from here →
1. (6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine
2. N-acetylglutamate synthase (N-acetylmethionine)
3. propanoyl-CoA C-acyltransferase
Catalysed by MTR, NAGS, ACAA1, SCP2 and 1 moremitochondrial matrix, peroxisomeOne of 2 routes
palmitoyl-CoAReach from here →
1. (6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine
2. N-acetylglutamate synthase (N-acetylmethionine)
3. Palmitate:CoA ligase (AMP-forming)
Catalysed by MTR, NAGS, SLC27A2, ACSL4 and 6 moremitochondrial matrix, cytosolOne of 11 routes
oleoyl-CoAReach from here →
1. (6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine
2. N-acetylglutamate synthase (N-acetylmethionine)
3. Transport of octadecenoyl-CoA into Mitochondrial Matrix
Catalysed by MTR, NAGS, CPT1A, CPT1C and 1 moremitochondrial matrix, cytosolOne of 11 routes