oxaloacetate

Three steps

• beta-carbolineReach from here →
  1. L-Aspartate:2-oxoglutarate aminotransferase
  2. L-tryptophan(out) + L-aspartate(in) = L-tryptophan(in) + L-aspartate(out)
  3. beta-carboline hydrolysis

  Catalysed by GOT2, SLC7A13mitochondrial matrix, inner side of the membrane, outer side of the membrane, cytosol

• (S)-3-hydroxybutanoateReach from here →
  1. Oxaloacetate Decarboxylase
  2. transport of acetoacetate and pyruvate (cytosol to mitochondria)
  3. (S)-3-hydroxybutanoate + 2-oxoglutarate = (R)-2-hydroxyglutarate + acetoacetate

  Catalysed by FAHD1, ADHFE1cytosol, mitochondrial matrix

• N(omega)-methyl-L-arginineReach from here →
  1. L-Aspartate:2-oxoglutarate aminotransferase
  2. oxaloacetate + L-alanine = L-aspartate + pyruvate
  3. N(omega)-methyl-L-arginine + pyruvate = 5-(3-methylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by GOT2, AGXT2mitochondrial matrixOne of 4 routes

• 3-hydroxy-2-methylpropanoateReach from here →
  1. Oxaloacetate Decarboxylase
  2. (R)-3-amino-2-methylpropanoate + pyruvate = 2-methyl-3-oxopropanoate + L-alanine
  3. 3-hydroxy-2-methylpropanoate + NAD(+) = 2-methyl-3-oxopropanoate + NADH + H(+)

  Catalysed by FAHD1, AGXT2, HIBADHcytosol

• 3-methyl-2-oxobutanoateReach from here →
  1. L-Aspartate:2-oxoglutarate aminotransferase
  2. L-valine(out) + L-aspartate(in) = L-valine(in) + L-aspartate(out)
  3. L-Valine:2-oxoglutarate aminotransferase

  Catalysed by GOT2, SLC7A13, BCAT2mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 3 routes

• AReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

  Catalysed by CS, NAGS, MOCOSmitochondrial matrix

• (5E)-tetradecenoyl-(R)-carnitineReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. Carnitine O-Palmitoyltransferase
  3. carnitine O-palmitoyltransferase ((9E)-tetradecenoyl-CoA)

  Catalysed by CS, CPT1A, CPT1C, CPT1Bmitochondrial matrix, cytosolOne of 7 routes

• S-butanoyl-4'-phosphopantetheineReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. Butanoate:CoA ligase (AMP-forming)
  3. butanoyl-CoA + H2O = S-butanoyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)

  Catalysed by CS, ACSM4, ACSM1, ACSM2A and 6 moremitochondrial matrix, cytosol

• S-octanoyl-4'-phosphopantetheineReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. Octanoyl-CoA:L-carnitine O-octanoyltransferase
  3. octanoyl-CoA + H2O = S-octanoyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)

  Catalysed by CS, CROT, NUDT19, NUDT7 and 1 moremitochondrial matrix

• decanoyl-4'-phosphopantetheineReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. medium-chain acyl-CoA ligase (decanoic acid)
  3. decanoyl-CoA + H2O = decanoyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)

  Catalysed by CS, ACSM4, ACSM1, ACSM2A and 4 moremitochondrial matrix, cytosol

• S-dodecanoyl-4'-phosphopantetheineReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. long-chain-fatty-acid-CoA ligase (lauric acid)
  3. dodecanoyl-CoA + H2O = S-dodecanoyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)

  Catalysed by CS, SLC27A2, ACSL4, ACSL3 and 7 moremitochondrial matrix, cytosol

• tetradecanoyl-4'-phosphopantetheineReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. long-chain-fatty-acid-CoA ligase (myristic acid)
  3. tetradecanoyl-CoA + H2O = tetradecanoyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)

  Catalysed by CS, SLC27A2, ACSL4, ACSL3 and 7 moremitochondrial matrix, cytosol

• an acyl-4'-phosphopantetheineReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. acyl-CoA:sphingosine N-acyltransferase
  3. an acyl-CoA + H2O = an acyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)

  Catalysed by CS, ASAH1, ACER2, ACER1 and 4 moremitochondrial matrix, Golgi apparatus

• tauroursodeoxycholateReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)
  3. taurine to tauroursodeoxycholate conversion

  Catalysed by CS, BAATmitochondrial matrix, cytosolOne of 2 routes

• glycoursodeoxycholateReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. glycine to glycoursodeoxycholate conversion

  Catalysed by CS, GLYAT, GLYATL2, GLYATL1mitochondrial matrix, cytosolOne of 2 routes

• a quinoneReach from here →
  1. transport of malate and OAA (cytosol to mitochondria)
  2. (S)-malate hydro-lyase (fumarate-forming)
  3. a quinone + succinate = fumarate + a quinol

  Catalysed by FH, SDHBmitochondrial matrix, cytosolOne of 7 routes

• pregnenolone sulfateReach from here →
  1. L-Aspartate:2-oxoglutarate aminotransferase
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. Steryl-Sulfatase

  Catalysed by GOT2, SLC25A14, SLC25A30, STSmitochondrial matrix, inner side of the membrane, outer side of the membrane, Golgi apparatusOne of 2 routes

• androsterone 3alpha-sulfateReach from here →
  1. L-Aspartate:2-oxoglutarate aminotransferase
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. steroid sulfatase (androsterone sulfate)

  Catalysed by GOT2, SLC25A14, SLC25A30, STSmitochondrial matrix, inner side of the membrane, outer side of the membrane, cytosolOne of 3 routes

• prostaglandin E3Reach from here →
  1. Oxaloacetate Decarboxylase
  2. (S)-Lactate:NAD+ oxidoreductase
  3. Transport of Prostaglandin E3, Lactate Antiport

  Catalysed by FAHD1, LDHB, LDHAL6Bcytosol, mitochondrial matrix, extracellular spaceOne of 4 routes

• prostaglandin A2Reach from here →
  1. Oxaloacetate Decarboxylase
  2. (S)-Lactate:NAD+ oxidoreductase
  3. Transport of Prostaglandin A2, Lactate Antiport

  Catalysed by FAHD1, LDHB, LDHAL6Bcytosol, mitochondrial matrix, extracellular spaceOne of 2 routes

• prostaglandin J2Reach from here →
  1. Oxaloacetate Decarboxylase
  2. (S)-Lactate:NAD+ oxidoreductase
  3. Transport of Prostaglandin J2, Lactate Antiport

  Catalysed by FAHD1, LDHB, LDHAL6Bcytosol, mitochondrial matrix, extracellular spaceOne of 2 routes

• 15-oxoprostaglandin F2alphaReach from here →
  1. Oxaloacetate Decarboxylase
  2. (S)-Lactate:NAD+ oxidoreductase
  3. Transport of 15-Keto-Prostaglandin F2A, Lactate Antiport

  Catalysed by FAHD1, LDHB, LDHAL6Bcytosol, mitochondrial matrix, extracellular spaceOne of 2 routes

• leukotriene F4Reach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. N-acetyl-LTE4 to leukotriene E4 conversion
  3. leukotriene F4 hydrolysis

  Catalysed by CS, ZDHHC11B, NAA10, ESCO2 and 29 moremitochondrial matrix, cytosol

• 2,4-dinitrophenyl-S-glutathioneReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. N-acetyl-LTE4 to leukotriene E4 conversion
  3. transport of leukotriene E4 (cytosol to extracellular)

  Catalysed by CS, ZDHHC11B, NAA10, ESCO2 and 30 moremitochondrial matrix, cytosol, extracellular spaceOne of 2 routes

• N-(9Z-octadecenoyl)glycineReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. (9Z)-octadecenoyl-CoA + glycine = N-(9Z-octadecenoyl)glycine + CoA + H(+)

  Catalysed by CS, GLYAT, GLYATL2, GLYATL1 and 1 moremitochondrial matrix

• N-(9Z-octadecenoyl)-L-phenylalanineReach from here →
  1. L-Aspartate:2-oxoglutarate aminotransferase
  2. L-aspartate(in) + L-phenylalanine(out) = L-aspartate(out) + L-phenylalanine(in)
  3. L-phenylalanine + (9Z)-octadecenoate = N-(9Z-octadecenoyl)-L-phenylalanine + H2O

  Catalysed by GOT2, SLC7A13, PM20D1mitochondrial matrix, inner side of the membrane, outer side of the membrane

• N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanineReach from here →
  1. L-Aspartate:2-oxoglutarate aminotransferase
  2. L-aspartate(in) + L-phenylalanine(out) = L-aspartate(out) + L-phenylalanine(in)
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + L-phenylalanine = N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanine + H2O

  Catalysed by GOT2, SLC7A13, PM20D1mitochondrial matrix, inner side of the membrane, outer side of the membrane

• N-(9Z-octadecenoyl)-L-leucineReach from here →
  1. L-Aspartate:2-oxoglutarate aminotransferase
  2. L-leucine(out) + L-aspartate(in) = L-leucine(in) + L-aspartate(out)
  3. N-(9Z-octadecenoyl)-L-leucine + H2O = L-leucine + (9Z)-octadecenoate

  Catalysed by GOT2, SLC7A13, PM20D1mitochondrial matrix, inner side of the membrane, outer side of the membrane

• N-octadecanoylglycineReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. long-chain-fatty-acid-CoA ligase (stearate)
  3. octadecanoyl-CoA + glycine = N-octadecanoylglycine + CoA + H(+)

  Catalysed by CS, SLC27A2, ACSL4, ACSL3 and 5 moremitochondrial matrix, cytosolOne of 2 routes

• N-(9Z-hexadecenoyl)-glycineReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. long-chain-fatty-acid-CoA ligase (palmitolate)
  3. (9Z)-hexadecenoyl-CoA + glycine = N-(9Z-hexadecenoyl)-glycine + CoA + H(+)

  Catalysed by CS, SLC27A2, ACSL4, ACSL3 and 6 moremitochondrial matrix, cytosolOne of 2 routes

• all-trans-4-hydroxyretinoateReach from here →
  1. Oxaloacetate Decarboxylase
  2. transport of pyruvate and retinoate (cytosol to extracellular)
  3. cytochrome P450 (retinoate)

  Catalysed by FAHD1, SLC16A4, SLC16A5, SLC16A3 and 4 morecytosol, extracellular spaceOne of 3 routes

• N-acetylcadaverineReach from here →
  1. Oxaloacetate Decarboxylase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. N-acetylcadaverine + H2O = cadaverine + acetate

  Catalysed by FAHD1, SLC16A4, SLC16A5, SLC16A3 and 3 morecytosol, extracellular space

• cholesterol sulfateReach from here →
  1. L-Aspartate:2-oxoglutarate aminotransferase
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. Steryl-Sulfatase

  Catalysed by GOT2, SLC25A14, SLC25A30, STSmitochondrial matrix, inner side of the membrane, outer side of the membrane, Golgi apparatusOne of 2 routes

• 5alpha-dihydrotestosterone sulfateReach from here →
  1. L-Aspartate:2-oxoglutarate aminotransferase
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. steroid sulfatase (5-alpha-dihydrotestosterone)

  Catalysed by GOT2, SLC25A14, SLC25A30, STSmitochondrial matrix, inner side of the membrane, outer side of the membrane, cytosolOne of 3 routes

• 2-hydroxyoctanoyl-CoAReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. Octanoyl-CoA:L-carnitine O-octanoyltransferase
  3. octanoyl-CoA + 2-oxoglutarate + O2 = 2-hydroxyoctanoyl-CoA + succinate + CO2

  Catalysed by CS, CROT, PHYHmitochondrial matrix

• 2-hydroxydecanoyl-CoAReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. medium-chain acyl-CoA ligase (decanoic acid)
  3. decanoyl-CoA + 2-oxoglutarate + O2 = 2-hydroxydecanoyl-CoA + succinate + CO2

  Catalysed by CS, ACSM4, ACSM1, ACSM2A and 4 moremitochondrial matrix, cytosol

• 2-hydroxyeicosanoyl-CoAReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. long-chain-fatty-acid-CoA ligase (eicosanoate)
  3. eicosanoyl-CoA + 2-oxoglutarate + O2 = 2-hydroxyeicosanoyl-CoA + succinate + CO2

  Catalysed by CS, SLC27A2, ACSL4, ACSL3 and 6 moremitochondrial matrix, cytosol

• 2-hydroxydodecanoyl-CoAReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. long-chain-fatty-acid-CoA ligase (lauric acid)
  3. dodecanoyl-CoA + 2-oxoglutarate + O2 = 2-hydroxydodecanoyl-CoA + succinate + CO2

  Catalysed by CS, SLC27A2, ACSL4, ACSL3 and 6 moremitochondrial matrix, cytosol

• 2-hydroxytetradecanoyl-CoAReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. long-chain-fatty-acid-CoA ligase (myristic acid)
  3. tetradecanoyl-CoA + 2-oxoglutarate + O2 = 2-hydroxytetradecanoyl-CoA + succinate + CO2

  Catalysed by CS, SLC27A2, ACSL4, ACSL3 and 6 moremitochondrial matrix, cytosol

• 11-cis-retinyl tetradecanoateReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. long-chain-fatty-acid-CoA ligase (myristic acid)
  3. 11-cis-retinol + tetradecanoyl-CoA = 11-cis-retinyl tetradecanoate + CoA

  Catalysed by CS, SLC27A2, ACSL4, ACSL3 and 6 moremitochondrial matrix, cytosolOne of 2 routes

• 9-cis-retinyl tetradecanoateReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. long-chain-fatty-acid-CoA ligase (myristic acid)
  3. 9-cis-retinol + tetradecanoyl-CoA = 9-cis-retinyl tetradecanoate + CoA

  Catalysed by CS, SLC27A2, ACSL4, ACSL3 and 6 moremitochondrial matrix, cytosol

• 13-cis-retinyl tetradecanoateReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. long-chain-fatty-acid-CoA ligase (myristic acid)
  3. 13-cis-retinol + tetradecanoyl-CoA = 13-cis-retinyl tetradecanoate + CoA

  Catalysed by CS, SLC27A2, ACSL4, ACSL3 and 6 moremitochondrial matrix, cytosol

• all-trans-retinyl tetradecanoateReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. long-chain-fatty-acid-CoA ligase (myristic acid)
  3. all-trans-retinol + tetradecanoyl-CoA = all-trans-retinyl tetradecanoate + CoA

  Catalysed by CS, SLC27A2, ACSL4, ACSL3 and 6 moremitochondrial matrix, cytosol

• tetradecyl tetradecanoateReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. long-chain-fatty-acid-CoA ligase (myristic acid)
  3. tetradecan-1-ol + tetradecanoyl-CoA = tetradecyl tetradecanoate + CoA

  Catalysed by CS, SLC27A2, ACSL4, ACSL3 and 6 moremitochondrial matrix, cytosol

• 1-(9Z-octadecenoyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphateReach from here →
  1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  2. long-chain-fatty-acid-CoA ligase (DHA)
  3. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1-(9Z-octadecenoyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CoA

  Catalysed by CS, SLC27A2, ACSL4, ACSL3 and 6 moremitochondrial matrix, cytosol

• all-trans-retinoyl-1-O-(beta-D-glucuronate)Reach from here →
  1. Oxaloacetate Decarboxylase
  2. transport of pyruvate and retinoate (cytosol to extracellular)
  3. glucuronosyltransferase (retinoate)

  Catalysed by FAHD1, SLC16A4, SLC16A5, SLC16A3 and 6 morecytosol, extracellular space, endoplasmic reticulum

• all-trans-18-hydroxyretinoateReach from here →
  1. Oxaloacetate Decarboxylase
  2. transport of pyruvate and retinoate (cytosol to extracellular)
  3. unspecific monooxygenase (retinoate)

  Catalysed by FAHD1, SLC16A4, SLC16A5, SLC16A3 and 28 morecytosol, extracellular spaceOne of 2 routes

• a phenyl acetateReach from here →
  1. Oxaloacetate Decarboxylase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. a phenyl acetate + H2O = a phenol + acetate + H(+)

  Catalysed by FAHD1, SLC16A4, SLC16A5, SLC16A3 and 5 morecytosol, extracellular space

• an aryl sulfateReach from here →
  1. L-Aspartate:2-oxoglutarate aminotransferase
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. an aryl sulfate + H2O = a phenol + sulfate + H(+)

  Catalysed by GOT2, SLC25A14, SLC25A30, ARSL and 5 moremitochondrial matrix, inner side of the membrane, outer side of the membrane

• 3-sulfinopyruvateReach from here →
  1. L-Aspartate:2-oxoglutarate aminotransferase
  2. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  3. 3-sulfino-L-alanine:2-oxoglutarate aminotransferase

  Catalysed by GOT2, SLC25A12, SLC25A13, GOT1mitochondrial matrix, cytosolOne of 2 routes