N-dodecanoylglycine

Two steps

• CHEBI:28666Reach from here →
  1. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  2. LTD4 hydrolysis

  Catalysed by GLYATL2cytosol

• Cu(2+)Reach from here →
  1. N-dodecanoylglycine + 2 L-ascorbate + O2 = N-dodecanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O
  2. Cu(2+)(out) + L-ascorbate(in) = Cu(+)(out) + monodehydro-L-ascorbate radical(in) + H(+)

  Catalysed by PAM, CYBRD1inner side of the membrane, outer side of the membrane

• L-ascorbic acidReach from here →
  1. N-dodecanoylglycine + 2 L-ascorbate + O2 = N-dodecanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O
  2. N-dodecanoylglycine + 2 L-ascorbate + O2 = N-dodecanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O

  Catalysed by PAMOne of 10 routes

• Gly-tRNA(Gly)Reach from here →
  1. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  2. glycine:tRNA(Gly) ligase (AMP-forming)

  Catalysed by GLYATL2, GARS1cytosol

• chlorine(.)Reach from here →
  1. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  2. transport of chloride and glycine (cytosol to extracellular)

  Catalysed by GLYATL2, SLC6A9, SLC6A14extracellular space, cytosolOne of 3 routes

• glycocholateReach from here →
  1. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  2. bile acid-CoA: amino acid N-acyltransferase

  Catalysed by GLYATL2, BAATperoxisomeOne of 3 routes

• dodecanamideReach from here →
  1. N-dodecanoylglycine + 2 L-ascorbate + O2 = N-dodecanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O
  2. N-dodecanoyl-(2S)-hydroxyglycine = dodecanamide + glyoxylate

  Catalysed by PAM

• 5-aminolevulinateReach from here →
  1. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  2. succinyl-CoA + glycine + H(+) = 5-aminolevulinate + CO2 + CoA

  Catalysed by GLYATL2, ALAS1, ALAS2

• glycochenodeoxycholateReach from here →
  1. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  2. chenodeoxycholoyl-CoA + glycine = glycochenodeoxycholate + CoA + H(+)

  Catalysed by GLYATL2, BAAT

• glycochenodeoxycholic acidReach from here →
  1. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  2. bile acid-CoA: amino acid N-acyltransferase

  Catalysed by GLYATL2, BAATperoxisomeOne of 3 routes

• glyoxylateReach from here →
  1. N-dodecanoylglycine + 2 L-ascorbate + O2 = N-dodecanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O
  2. N-dodecanoyl-(2S)-hydroxyglycine = dodecanamide + glyoxylate

  Catalysed by PAMOne of 12 routes

• glycolithocholic acidReach from here →
  1. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  2. bile acid-CoA:amino acid N-acyltransferase (glycine)

  Catalysed by GLYATL2, BAATcytosolOne of 2 routes

• L-2-amino-3-oxobutanoic acidReach from here →
  1. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  2. Acetyl-CoA:glycine C-acetyltransferase

  Catalysed by GLYATL2, GCATmitochondrial matrix

• L-ornithineReach from here →
  1. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  2. L-Arginine:glycine amidinotransferase

  Catalysed by GLYATL2, GATMcytosolOne of 5 routes

• S(8)-aminomethyldihydrolipoamideReach from here →
  1. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  2. dihydrolipoyl dehydrogenase ([protein]-N6-(lipoyl)lysine)

  Catalysed by GLYATL2, GLDC, GCSHmitochondrial matrix

• (2E)-dodecenoyl-CoAReach from here →
  1. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  2. trans-dodec-2-enoyl-CoA reductase

  Catalysed by GLYATL2, MECRmitochondrial matrixOne of 5 routes

• tetradecanoyl-CoAReach from here →
  1. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  2. fatty-acyl-CoA synthase (N-C14:0CoA)

  Catalysed by GLYATL2cytosol

• sarcosineReach from here →
  1. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  2. sarcosine + O2 + H2O = formaldehyde + glycine + H2O2

  Catalysed by GLYATL2, PIPOXOne of 2 routes

• (6S)-5,6,7,8-tetrahydrofolateReach from here →
  1. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine

  Catalysed by GLYATL2, SHMT1, SHMT2

• an N-acylglycineReach from here →
  1. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  2. an acyl-CoA + glycine = an N-acylglycine + CoA + H(+)

  Catalysed by GLYATL2, GLYATL3, GLYAT

• guanidinoacetateReach from here →
  1. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  2. L-Arginine:glycine amidinotransferase

  Catalysed by GLYATL2, GATMcytosolOne of 2 routes

• L-methionineReach from here →
  1. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  2. transport of glycine and methionine (cytosol to extracellular)

  Catalysed by GLYATL2, SLC7A5extracellular space, cytosolOne of 5 routes

• L-tryptophanReach from here →
  1. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  2. transport of glycine and tryptophan (cytosol to extracellular)

  Catalysed by GLYATL2, SLC7A5extracellular space, cytosolOne of 5 routes

• glutathioneReach from here →
  1. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)

  Catalysed by GLYATL2, GSS

• L-alanineReach from here →
  1. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  2. transport of alanine and glycine (cytosol to extracellular)

  Catalysed by GLYATL2, SLC3A2, SLC7A5, SLC7A10extracellular space, cytosolOne of 6 routes

• leukotriene C4Reach from here →
  1. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  2. leukotriene C4 hydrolysis

  Catalysed by GLYATL2cytosol

• L-asparagineReach from here →
  1. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  2. transport of asparagine and glycine (cytosol to extracellular)

  Catalysed by GLYATL2extracellular space, cytosolOne of 4 routes

• L-phenylalanineReach from here →
  1. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  2. transport of glycine and phenylalanine (cytosol to extracellular)

  Catalysed by GLYATL2, SLC7A5extracellular space, cytosolOne of 7 routes

• L-tyrosineReach from here →
  1. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  2. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine

  Catalysed by GLYATL2, AADAT

• N(omega),N(omega)-dimethyl-L-arginineReach from here →
  1. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  2. N(omega),N(omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + glycine

  Catalysed by GLYATL2, AGXT2

• an acyl-CoAReach from here →
  1. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  2. acyl-CoA pool formation and breakdown

  Catalysed by GLYATL2cytosol

• N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycineReach from here →
  1. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  2. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + glycine = N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + CoA + H(+)

  Catalysed by GLYATL2One of 2 routes

• N-benzoylglycineReach from here →
  1. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  2. Hippurate (Benzoylglycinate) Formation

  Catalysed by GLYATL2mitochondrial matrixOne of 2 routes

• decanoyl-CoAReach from here →
  1. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  2. Fatty Acid Beta Oxidation (C12->C10), Mitochondrial

  Catalysed by GLYATL2, ACADM, ECHS1, ACAA2 and 1 moremitochondrial matrixOne of 2 routes

• 3-oxotetradecanoyl-CoAReach from here →
  1. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  2. dodecanoyl-CoA + malonyl-CoA + H(+) = 3-oxotetradecanoyl-CoA + CO2 + CoA

  Catalysed by GLYATL2, ELOVL6

• 3-oxotetradecasphinganineReach from here →
  1. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  2. dodecanoyl-CoA + L-serine + H(+) = 3-oxotetradecasphinganine + CO2 + CoA

  Catalysed by GLYATL2, SPTLC1, SPTLC3

• 1-dodecanoyl-sn-glycerol 3-phosphateReach from here →
  1. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  2. glycerol-3-phosphate 1-O-acyltransferase (lauroyl-CoA)

  Catalysed by GLYATL2, GPAT3, GPAT2, GPAT4 and 1 morecytosolOne of 2 routes

• (2S)-2-aminobutanoateReach from here →
  1. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  2. (2S)-2-aminobutanoate + glyoxylate = 2-oxobutanoate + glycine

  Catalysed by GLYATL2, AGXT2

• 1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phosphocholineReach from here →
  1. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  2. dodecanoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phosphocholine + CoA

  Catalysed by GLYATL2, LPCAT3, LPCAT1

• 1-(9Z)-octadecenoyl-2-dodecanoyl-sn-glycero-3-phosphateReach from here →
  1. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  2. 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + dodecanoyl-CoA = 1-(9Z)-octadecenoyl-2-dodecanoyl-sn-glycero-3-phosphate + CoA

  Catalysed by GLYATL2, AGPAT1

• 1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phospho-(1D-myo-inositol)Reach from here →
  1. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  2. 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + dodecanoyl-CoA = 1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA

  Catalysed by GLYATL2, LCLAT1

• 1'-[1-acyl-2-dodecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerolReach from here →
  1. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  2. 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + dodecanoyl-CoA = 1'-[1-acyl-2-dodecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA

  Catalysed by GLYATL2, LCLAT1

• 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-dodecanoyl-sn-glycero-3-phospho]-glycerolReach from here →
  1. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  2. 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + dodecanoyl-CoA = 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-dodecanoyl-sn-glycero-3-phospho]-glycerol + CoA

  Catalysed by GLYATL2, LCLAT1

• 1-dodecanoyl-2-(9Z-octadecenoyl)-glycerolReach from here →
  1. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  2. 2-(9Z-octadecenoyl)-glycerol + dodecanoyl-CoA = 1-dodecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA

  Catalysed by GLYATL2, MOGAT2, MOGAT1

• 1-(9Z-octadecenoyl)-2-dodecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
  1. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  2. 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + dodecanoyl-CoA = 1-(9Z-octadecenoyl)-2-dodecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA

  Catalysed by GLYATL2, LPGAT1

• 1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
  1. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  2. 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + dodecanoyl-CoA = 1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA

  Catalysed by GLYATL2, LPGAT1

• O-dodecanoyl-R-carnitineReach from here →
  1. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  2. carnitine O-palmitoyltransferase (dodecanoylcarnitine)

  Catalysed by GLYATL2, CPT1A, CPT1C, CPT1BcytosolOne of 4 routes

• glycodeoxycholateReach from here →
  1. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  2. Glycodeoxycholate amidohydrolase

  Catalysed by GLYATL2cytosolOne of 2 routes

• N-tetradecanoylglycineReach from here →
  1. N-dodecanoylglycine + 2 L-ascorbate + O2 = N-dodecanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O
  2. N-tetradecanoylglycine + 2 L-ascorbate + O2 = N-tetradecanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O

  Catalysed by PAMOne of 2 routes

• N-eicosanoylglycinateReach from here →
  1. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  2. eicosanoyl-CoA + glycine = N-eicosanoylglycinate + CoA + H(+)

  Catalysed by GLYATL2, BAAT