Pathway

Defective PNP disrupts phosphorolysis of (deoxy)guanosine and (deoxy)inosine

Normally in humans, PNP (purine nucleotide phosphorylase) catalyzes the conversion of (deoxy)guanosine and (deoxy)inosine to guanine and hypoxanthine, respectively. In the absence of PNP activity, however, these purine nucleosides accumulate, disrupting lymphoid cell function and leading to severe immunodeficiency.

Summary from Reactome (R-HSA-9735763), read 2026-09-23.

REACT:R-HSA-9735763Reactome

Open in the graph

What the reference databases state

Statements

1 statement

1 statement · 1 reference database · Subject: Defective PNP disrupts phosphorolysis of (deoxy)guanosine and (deoxy)inosine · Sources: Reactome

Order

PNP participates in Defective PNP disrupts phosphorolysis of (deoxy)guanosine and (deoxy)inosineProteinReactome R-HSA-9735763Inferred only