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Proteins/UNIPROT:P19634
Electroneutral Na(+) /H(+) antiporter that extrudes Na(+) in exchange for external protons driven by the inward sodium ion chemical gradient, protecting cells from acidification that occurs from metabolism. Exchanges intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry (By similarity). Plays a key role in maintening intracellular pH neutral and cell volume, and thus is important for cell growth, proliferation, migration and survival. In addition, can transport lithium Li(+) and also functions as a Na(+)/Li(+) antiporter. SLC9A1 also functions in membrane anchoring and organization of scaffolding complexes that coordinate signaling inputs..
Function from UniProtKB (P19634), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · transported by
1 compound
1 compound.
0 reported routes1 assembled route
1 row
193 statements
193 statements · 6 reference databases · Subject: SLC9A1 · Sources: gene ontology, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
5 reactions
sodium(1+)+ammoniumsodium(1+)+ammonium
Transported by SLC9A3 or SLC9A1 or SLC9A2
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR01528CC BY 4.0Reference data
7 names
Resolves to: SLC9A1
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR05430CC BY 4.0Reference data
sodium(1+)+hydronsodium(1+)+hydron
Transported by SLC9A1 or SLC9A3 or SLC9A5 or SLC9A4 or SLC9B2 or SLC9A9 or SLC9A6 or SLC9A7 or SLC9A2 or SLC9A8
Reaction pageReversibleBalanced
Rhea RHEA:29419CC BY 4.0Reference data
Transported by SLC9A1 or SLC9B2
Reaction pageDirection not assertedBalanced
Rhea RHEA:72407CC BY 4.0Reference data
Li(+)+sodium(1+)Li(+)+sodium(1+)
Transported by SLC9A1 or SLC9B2
Reaction pageDirection not assertedBalanced
Rhea RHEA:72415CC BY 4.0Reference data