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Proteins/UNIPROT:O75164
Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Also able to demethylate histone H1-4 methylated at 'Lys-26' (H1.4K26me1, H1.4K26me2 and H1.4K26me3). Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively..
[Isoform 2]: Crucial for muscle differentiation, promotes transcriptional activation of the Myog gene by directing the removal of repressive chromatin marks at its promoter. Lacks the N-terminal demethylase domain..
Function from UniProtKB (O75164), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
94 statements
94 statements · 6 reference databases · Subject: KDM4A · Sources: gene ontology, Hetionet, Reactome, Rhea, UniProt, WikiPathways
2 reactions
N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3]+22-oxoglutarate(2-)+2dioxygenN(6)-methyl-L-lysyl(9)-[histone H3]+2formaldehyde+2succinate(2-)+2carbon dioxide
Catalysed by KDM4F or KDM4E or KDM4A or KDM4B or KDM4D or KDM4C
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:60200CC BY 4.0Reference data
8 names
Resolves to: KDM4A
N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3]+22-oxoglutarate(2-)+2dioxygenN(6)-methyl-L-lysyl(36)-[histone H3]+2formaldehyde+2succinate(2-)+2carbon dioxide
Catalysed by KDM4A
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:60236CC BY 4.0Reference data