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Proteins/UNIPROT:P11908
Catalyzes the transfer of the pyrophosphoryl group from ATP to the 1-hydroxyl of ribose-5-phosphate to form 5-phospho-ribosyl-1-pyrophosphate (PRPP), a key intermediate in the biosynthesis of several metabolites including nucleotides, dinucleotides and some amino acids. Involved in the production of newly synthesized ATP/GTP through the purine biosynthesis pathway..
Function from UniProtKB (P11908), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
50 statements
50 statements · 8 reference databases · Subject: PRPS2 · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
2 reactions
ATP+CHEBI:17797AMP+proton+5-phospho-alpha-D-ribose 1-diphosphate
Catalysed by PRPS2 or PRPS1 or PRPS1L1
Reaction pageLeft to rightBalancedEC 2.7.6.1cytosol
Human-GEM MAR04052CC BY 4.0Reference data
D-ribose 5-phosphate+ATP(4-)5-phospho-alpha-D-ribose 1-diphosphate+AMP+
5 names
Resolves to: PRPS2
Reaction pageLeft to rightBalanced
Rhea RHEA:15609CC BY 4.0Reference data