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Proteins/UNIPROT:Q9UBC3
Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co-repressor by associating with CBX4 and independently of DNA methylation. Seems to be involved in gene silencing (By similarity). In association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Isoforms 4 and 5 are probably not functional due to the deletion of two conserved methyltransferase motifs. Functions as a transcriptional corepressor by associating with ZHX1. Required for DUX4 silencing in somatic cells..
Function from UniProtKB (Q9UBC3), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
3 rows
139 statements
139 statements · 6 reference databases · Subject: DNMT3B · Sources: Bgee, gene ontology, Hetionet, Human Protein Atlas, Reactome, WikiPathways
4 reactions
MAM01721c+S-adenosyl-L-methionineMAM01722c+proton+CHEBI:16680
Catalysed by DNMT1 & DNMT3B or TRDMT1 or DNMT3A or DNMT3L
Reaction pageLeft to rightBalance undeterminableEC 2.1.1.37cytosol
Human-GEM MAR04072CC BY 4.0Reference data
MAM01721n+MAM02882nMAM01722n+proton+MAM02881n
4 names
Resolves to: DNMT3B
Reaction pageLeft to rightBalance undeterminableEC 2.1.1.37nucleus
Human-GEM MAR08640CC BY 4.0Reference data
MAM01721n+S-adenosyl-L-methionineMAM01722n+proton+CHEBI:16680
Catalysed by DNMT1 & DNMT3B or TRDMT1 or DNMT3A or DNMT3L
Reaction pageLeft to rightBalance undeterminableEC 2.1.1.37nucleus
Human-GEM MAR08641CC BY 4.0Reference data
a 2'-deoxycytidine in DNA+S-adenosyl-L-methioninea 5-methyl-2'-deoxycytidine in DNA+S-adenosyl-L-homocysteine+hydron
Catalysed by DNMT1 or DNMT3B or DNMT3A
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:13681CC BY 4.0Reference data