Papers/PMID:32347270
Prospective randomized trial evaluating blood and prostate tissue concentrations of green tea polyphenols and quercetin in men with prostate cancer.
Food & function2020The record
2 findings · 1 compound · 2 endpoints · 2 null
What it reported
How to read these marksEvery finding here is a null result.
What did not
2 findings
quercetin — inhibits COMT
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.FindingNull result“Supplementation with GT + Q compared to GT + PL did not lead to changes in gene and protein expression or enzyme activity of COMT and DNMT in prostate tissue and red blood cells (Tables 4 and 5).”
Quoted verbatim from Prospective randomized trial evaluating blood and prostate tissue concentrations of green tea polyphenols and quercetin in men with prostate cancer.. - Study
- RCT
- Duration
- 4 weeks
- Dose
- 800 mg quercetin daily (400 mg twice daily) with 1 g green tea extract, about 4 weeks
- Population
- 31 men with localised prostate cancer before prostatectomy; green tea extract given in both arms, quercetin or placebo added
Prospective randomized trial evaluating blood and prostate tissue concentrations of green tea polyphenols and quercetin in men with prostate cancer.2020PMID:32347270Permalink
quercetin — inhibits DNMT1
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.FindingNull result“Supplementation with GT + Q compared to GT + PL did not lead to changes in gene and protein expression or enzyme activity of COMT and DNMT in prostate tissue and red blood cells (Tables 4 and 5).”
Quoted verbatim from Prospective randomized trial evaluating blood and prostate tissue concentrations of green tea polyphenols and quercetin in men with prostate cancer.. - Study
- RCT
- Duration
- 4 weeks
- Dose
- 800 mg quercetin daily (400 mg twice daily) with 1 g green tea extract, about 4 weeks
- Population
- 31 men with localised prostate cancer before prostatectomy; green tea extract given in both arms, quercetin or placebo added
Prospective randomized trial evaluating blood and prostate tissue concentrations of green tea polyphenols and quercetin in men with prostate cancer.2020PMID:32347270Permalink