Proteins/UNIPROT:O95198

KLHL2

ProteinUNIPROT:O95198

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, WNK1, WNK3 and WNK4, leading most often to their proteasomal degradation. The BCR(KLHL2) complex catalyzes ubiquitination and degradation of NPTXR (By similarity). Responsible for degradative ubiquitination of the WNK kinases WNK1, WNK3 and WNK4. Plays a role in the reorganization of the actin cytoskeleton. Promotes growth of cell projections in oligodendrocyte precursors..

Function from UniProtKB (O95198), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

27 statements

27 statements · 2 reference databases · Subject: KLHL2 · Sources: Hetionet, Reactome

Order

ACTC1 interacts with KLHL2ProteinHetionet hetionet:interacts:11275-70Inferred only
CUL3 interacts with KLHL2ProteinHetionet hetionet:interacts:11275-8452Inferred only
KEAP1 interacts with KLHL2ProteinHetionet hetionet:interacts:11275-9817Inferred only
KLHL2 interacts with KLHL12ProteinHetionet hetionet:interacts:11275-59349Inferred only
KLHL2 interacts with NACC1ProteinHetionet hetionet:interacts:11275-112939Inferred only
KLHL2 participates in Adaptive Immune SystemPathwayReactome R-HSA-1280218Inferred only
KLHL2 participates in Antigen processing: Ubiquitination & Proteasome degradationPathwayReactome R-HSA-983168Inferred only
KLHL2 participates in Class I MHC mediated antigen processing & presentationPathwayReactome R-HSA-983169Inferred only
KLHL2 participates in Immune SystemPathwayReactome R-HSA-168256Inferred only
KLHL2 participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only
KLHL2 participates in NeddylationPathwayReactome R-HSA-8951664Inferred only
KLHL2 participates in Post-translational protein modificationPathwayReactome R-HSA-597592Inferred only

Show the remaining 15

KLHL2 decreases the expression of ACDProteinHetionet hetionet:regulates:11275-65057Inferred only
AOC3 increases the expression of KLHL2ProteinHetionet hetionet:regulates:8639-11275Inferred only
KLHL2 increases the expression of CASP2ProteinHetionet hetionet:regulates:11275-835Inferred only
KLHL2 increases the expression of CBLBProteinHetionet hetionet:regulates:11275-868Inferred only
KLHL2 increases the expression of CES1ProteinHetionet hetionet:regulates:11275-1066Inferred only
KLHL2 decreases the expression of DNMT1ProteinHetionet hetionet:regulates:11275-1786Inferred only
GAMT increases the expression of KLHL2ProteinHetionet hetionet:regulates:2593-11275Inferred only
KLHL2 increases the expression of HES1ProteinHetionet hetionet:regulates:11275-3280Inferred only
KLHL2 increases the expression of IKBKEProteinHetionet hetionet:regulates:11275-9641Inferred only
KLHL2 increases the expression of KLHL21ProteinHetionet hetionet:regulates:11275-9903Inferred only
KLHL2 increases the expression of MAP3K4ProteinHetionet hetionet:regulates:11275-4216Inferred only
KLHL2 increases the expression of SERPINA3ProteinHetionet hetionet:regulates:11275-12Inferred only
KLHL2 increases the expression of SQORProteinHetionet hetionet:regulates:11275-58472Inferred only
KLHL2 increases the expression of SSBP2ProteinHetionet hetionet:regulates:11275-23635Inferred only
TIMP2 increases the expression of KLHL2ProteinHetionet hetionet:regulates:7077-11275Inferred only

Other names

2 names

Resolves to: KLHL2

Also called: Actin-binding protein MayvenKelch-like protein 2

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