Pathway
STAT3 nuclear events downstream of ALK signaling
Activation of the STAT3 pathway downstream of ALK signaling contributes to cellular survival by modulating expression of a number of genes involved in apoptosis, immune response and angiogenesis (reviewed in Werner et al, 2009). The STAT3 pathway is particularly important in ALK+ cancers that express ALK fusion proteins, where STAT3 contributes to the repression of a number of tumor suppressor genes, highlighting its role as a critical oncogene (reviewed in Yu et al, 2014; Guanizo et al, 2018).
REACT:R-HSA-9701898Reactome
What the reference databases state
Statements
11 statements
11 statements · 1 reference database · Subject: STAT3 nuclear events downstream of ALK signaling · Sources: Reactome
- CD274 participates in STAT3 nuclear events downstream of ALK signalingProteinReactome R-HSA-9701898Inferred only
- DNMT1 participates in STAT3 nuclear events downstream of ALK signalingProteinReactome R-HSA-9701898Inferred only
- EP300 participates in STAT3 nuclear events downstream of ALK signalingProteinReactome R-HSA-9701898Inferred only
- HDAC1 participates in STAT3 nuclear events downstream of ALK signalingProteinReactome R-HSA-9701898Inferred only
- HDAC2 participates in STAT3 nuclear events downstream of ALK signalingProteinReactome R-HSA-9701898Inferred only
- HDAC3 participates in STAT3 nuclear events downstream of ALK signalingProteinReactome R-HSA-9701898Inferred only
- HIF1A participates in STAT3 nuclear events downstream of ALK signalingProteinReactome R-HSA-9701898Inferred only
- IL2RG participates in STAT3 nuclear events downstream of ALK signalingProteinReactome R-HSA-9701898Inferred only
- PRDM1 participates in STAT3 nuclear events downstream of ALK signalingProteinReactome R-HSA-9701898Inferred only
- SIN3A participates in STAT3 nuclear events downstream of ALK signalingProteinReactome R-HSA-9701898Inferred only
- STAT3 participates in STAT3 nuclear events downstream of ALK signalingProteinReactome R-HSA-9701898Inferred only