Pathway
Glucocorticoid biosynthesis
Cortisol, the major human glucocorticoid, is synthesized in the zona fasciculata of the adrenal cortex from pregnenolone. Pregnenolone is converted to 17alpha-hydoxyprogesterone in two reactions, both catalyzed by 3-beta-hydroxysteroid dehydrogenase/isomerase. 17Alpha-hydroxyprogesterone is hydroxylated by CYP21A2 to form 11-deoxycortisol, which in turn is converted to cortisol by CYP11B1. The conversion of the active steroid hormone, cortisol, to inactive cortisone occurs in many tissues, notably the liver.
REACT:R-HSA-194002Reactome
Also named: WP:5280
What the reference databases state
Statements
10 statements
10 statements · 1 reference database · Subject: Glucocorticoid biosynthesis · Sources: Reactome
- CYP11B1 participates in Glucocorticoid biosynthesisProteinReactome R-HSA-194002Inferred only
- CYP11B2 participates in Glucocorticoid biosynthesisProteinReactome R-HSA-194002Inferred only
- CYP17A1 participates in Glucocorticoid biosynthesisProteinReactome R-HSA-194002Inferred only
- CYP21A2 participates in Glucocorticoid biosynthesisProteinReactome R-HSA-194002Inferred only
- HSD11B1 participates in Glucocorticoid biosynthesisProteinReactome R-HSA-194002Inferred only
- HSD11B2 participates in Glucocorticoid biosynthesisProteinReactome R-HSA-194002Inferred only
- HSD3B1 participates in Glucocorticoid biosynthesisProteinReactome R-HSA-194002Inferred only
- HSD3B2 participates in Glucocorticoid biosynthesisProteinReactome R-HSA-194002Inferred only
- POMC participates in Glucocorticoid biosynthesisProteinReactome R-HSA-194002Inferred only
- SERPINA6 participates in Glucocorticoid biosynthesisProteinReactome R-HSA-194002Inferred only