Proteins/UNIPROT:Q6TCH7

PAQR3

ProteinUNIPROT:Q6TCH7

Golgi-scaffold protein which modulates its interactors activities by anchoring them to the Golgi apparatus. Functions as a spatial regulator of RAF1 kinase by sequestrating it to the Golgi apparatus. Acts as a positive regulator of cholesterol biosynthesis by mediating the anchoring of the SCAP:SREBP complex in the Golgi apparatus, thereby promoting SCAP:SREBF2 complex formation, potentiating SREBF2 and SREBF1 processing and enhancing lipid synthesis. Also regulates PPARA and PPARG functions by mediating their interaction with E3 ubiquitin ligases, such as STUB1 or HUWE1, leading to their polyubiquitination and proteasome-mediated degradation (By similarity)..

Function from UniProtKB (Q6TCH7), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

27 statements

27 statements · 3 reference databases · Subject: PAQR3 · Sources: gene ontology, Hetionet, Reactome

Order

PAQR3 covaries with MIB2ProteinHetionet hetionet:covaries:142678-152559Inferred only
PAQR3 covaries with NUMBLProteinHetionet hetionet:covaries:152559-9253Inferred only
RAF1 interacts with PAQR3ProteinHetionet hetionet:interacts:152559-5894Inferred only
UBC interacts with PAQR3ProteinHetionet hetionet:interacts:152559-7316Inferred only
PAQR3 participates in MAPK family signaling cascadesPathwayReactome R-HSA-5683057Inferred only
PAQR3 participates in MAPK1/MAPK3 signalingPathwayReactome R-HSA-5684996Inferred only
PAQR3 participates in Negative regulation of MAPK pathwayPathwayReactome R-HSA-5675221Inferred only
PAQR3 participates in RAF/MAP kinase cascadePathwayReactome R-HSA-5673001Inferred only
PAQR3 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
PAQR3 regulates negative regulation of MAP kinase activityBiological processgene ontology Q6TCH7|GO:0043407Inferred only
PAQR3 regulates negative regulation of neuron projection developmentBiological processgene ontology Q6TCH7|GO:0010977Inferred only
PAQR3 regulates negative regulation of peptidyl-serine phosphorylationBiological processgene ontology Q6TCH7|GO:0033137Inferred only

Show the remaining 15

PAQR3 regulates negative regulation of peroxisome proliferator activated receptor signaling pathwayBiological processgene ontology Q6TCH7|GO:0035359Inferred only
PAQR3 regulates negative regulation of protein phosphorylationBiological processgene ontology Q6TCH7|GO:0001933Inferred only
PAQR3 regulates positive regulation of cholesterol biosynthetic processBiological processgene ontology Q6TCH7|GO:0045542Inferred only
PAQR3 regulates positive regulation of proteasomal ubiquitin-dependent protein catabolic processBiological processgene ontology Q6TCH7|GO:0032436Inferred only
PAQR3 regulates positive regulation of SREBP signaling pathwayBiological processgene ontology Q6TCH7|GO:2000640Inferred only
ARG1 increases the expression of PAQR3ProteinHetionet hetionet:regulates:383-152559Inferred only
CBR1 increases the expression of PAQR3ProteinHetionet hetionet:regulates:873-152559Inferred only
DCK decreases the expression of PAQR3ProteinHetionet hetionet:regulates:1633-152559Inferred only
DUT increases the expression of PAQR3ProteinHetionet hetionet:regulates:1854-152559Inferred only
HADH increases the expression of PAQR3ProteinHetionet hetionet:regulates:3033-152559Inferred only
IKBKB increases the expression of PAQR3ProteinHetionet hetionet:regulates:3551-152559Inferred only
KTN1 increases the expression of PAQR3ProteinHetionet hetionet:regulates:3895-152559Inferred only
PSMD10 increases the expression of PAQR3ProteinHetionet hetionet:regulates:5716-152559Inferred only
PTMS increases the expression of PAQR3ProteinHetionet hetionet:regulates:5763-152559Inferred only
STAT3 increases the expression of PAQR3ProteinHetionet hetionet:regulates:6774-152559Inferred only

Other names

3 names

Resolves to: PAQR3

Also called: Progestin and adipoQ receptor family member IIIRaf kinase trapping to GolgiRKTG

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