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Proteins/UNIPROT:Q8IY21
Positively regulates RIGI- and IFIH1/MDA5-dependent type I interferon and interferon inducible gene expression in response to viral infection. Binds ssRNA, dsRNA and dsDNA and can promote the binding of RIGI to dsRNA. Exhibits antiviral activity against hepatitis C virus and vesicular stomatitis virus (VSV). Selectively reduces infectious titers of viruses that depend on type II IRES-mediated translation by modulating ribosome occupancy on type II IRES-containing viral mRNAs, without affecting type I IRES-mediated translation..
Function from UniProtKB (Q8IY21), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
56 statements
56 statements · 2 reference databases · Subject: DDX60 · Sources: gene ontology, Hetionet
1 reaction
1 name
Resolves to: DDX60
Rhea RHEA:13065CC BY 4.0Reference data