Loading the page.
Proteins/UNIPROT:O95568
Protein-L-histidine N-tele-methyltransferase that specifically monomethylates RPL3, thereby regulating translation elongation. Histidine methylation of RPL3 regulates translation elongation by slowing ribosome traversal on tyrosine codons: slower elongation provides enough time for proper folding of synthesized proteins and prevents cellular aggregation of tyrosine-rich proteins..
Function from UniProtKB (O95568), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
20 statements
20 statements · 2 reference databases · Subject: METTL18 · Sources: gene ontology, Hetionet
1 reaction
L-histidyl-[protein]+S-adenosyl-L-methionineN(tele)-methyl-L-histidyl-[protein]+S-adenosyl-L-homocysteine+hydron
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:19369CC BY 4.0Reference data
4 names
Resolves to: METTL18