3-oxo-(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA

1. 3-oxo-(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + CoA = (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + acetyl-CoA

Catalysed by ACAA1

1. 3-oxo-(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + CoA = (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + acetyl-CoA
2. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA hydrolase

Catalysed by ACAA1, BAAT, ACOT6, ACOT1cytosolOne of 10 routes

1. 3-oxo-(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + CoA = (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + acetyl-CoA
2. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + O2 = (2E,5Z,8Z,11Z,14Z,17Z)-eicosahexaenoyl-CoA + H2O2

Catalysed by ACAA1, ACOX1

1. 3-oxo-(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + CoA = (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + acetyl-CoA
2. acyl-CoA pool formation and breakdown

Catalysed by ACAA1cytosol

1. 3-oxo-(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + CoA = (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + acetyl-CoA
2. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA hydrolase

Catalysed by ACAA1, BAAT, ACOT6, ACOT1cytosolOne of 2 routes

1. 3-oxo-(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + CoA = (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + acetyl-CoA
2. Beta Oxidation of Fatty Acid

Catalysed by ACAA1, ACADM, ACADSmitochondrial matrixOne of 2 routes

1. 3-oxo-(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + CoA = (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + acetyl-CoA
2. fatty-acyl-CoA elongation (N-C20:5CoA)

Catalysed by ACAA1, ELOVL4, ELOVL6, ELOVL2 and 1 morecytosol

1. 3-oxo-(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + CoA = (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + acetyl-CoA
2. Acyl-CoA:cholesterol O-acyltransferase

Catalysed by ACAA1, SOAT2, SOAT1endoplasmic reticulumOne of 2 routes

1. 3-oxo-(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + CoA = (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + acetyl-CoA
2. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA hydrolase
3. Carnitine O-Palmitoyltransferase

Catalysed by ACAA1, BAAT, ACOT6, ACOT1 and 3 morecytosolOne of 244 routes

1. 3-oxo-(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + CoA = (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + acetyl-CoA
2. Acyl-CoA:cholesterol O-acyltransferase
3. Steryl-ester acylhydrolase