L-threonine

1. L-threonine = acetaldehyde + glycine
2. transport of glycine and phenylalanine (cytosol to extracellular)

Catalysed by SHMT1, SLC7A5extracellular space, cytosolOne of 20 routes

1. L-threonine(out) + L-alanine(in) = L-threonine(in) + L-alanine(out)
2. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)

Catalysed by SLC7A10, KYNUinner side of the membrane, outer side of the membrane

1. L-threonine = acetaldehyde + glycine
2. phosphoethanolamine + H2O = acetaldehyde + NH4(+) + phosphate

Catalysed by SHMT1, ETNPPL

1. L-threonine(in) + L-glutamine(out) + Na(+)(out) = L-threonine(out) + L-glutamine(in) + Na(+)(in)
2. HCO3-:L-glutamine amido-ligase (ADP-forming, carbamate-phosphorylating)

Catalysed by SLC1A5, CADinner side of the membrane, outer side of the membrane, cytosolOne of 2 routes

1. L-threonine = acetaldehyde + glycine
2. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine

Catalysed by SHMT1, AADAT

1. L-threonine = acetaldehyde + glycine
2. N(omega),N(omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + glycine

Catalysed by SHMT1, AGXT2One of 2 routes

1. L-threonine = 2-oxobutanoate + NH4(+)
2. 2-oxobutanoate + L-kynurenine = (2S)-2-aminobutanoate + kynurenate + H2O

Catalysed by SDS, SDSL, AADAT

1. L-threonine(in) + L-glutamine(out) + Na(+)(out) = L-threonine(out) + L-glutamine(in) + Na(+)(in)
2. phosphoribosyl pyrophosphate amidotransferase (glutamine)

Catalysed by SLC1A5, PPATinner side of the membrane, outer side of the membrane, cytosolOne of 2 routes

1. L-threonine(in) + L-glutamine(out) + Na(+)(out) = L-threonine(out) + L-glutamine(in) + Na(+)(in)
2. D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate

Catalysed by SLC1A5, GFPT2, GFPT1inner side of the membrane, outer side of the membrane

1. L-threonine = acetaldehyde + glycine
2. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + glycine = N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + CoA + H(+)

Catalysed by SHMT1, GLYATL2One of 2 routes

1. L-threonine(out) + L-alanine(in) = L-threonine(in) + L-alanine(out)
2. L-proline(out) + L-alanine(in) + Na(+)(out) = L-proline(in) + L-alanine(out) + Na(+)(in)

Catalysed by SLC7A10, SLC1A4inner side of the membrane, outer side of the membraneOne of 2 routes

1. L-threonine = acetaldehyde + glycine
2. Hippurate (Benzoylglycinate) Formation

Catalysed by SHMT1mitochondrial matrixOne of 2 routes

1. L-threonine(out) + L-alanine(in) = L-threonine(in) + L-alanine(out)
2. gamma-glutamyltransferase (alanine)

Catalysed by SLC7A10, GGTLC3, GGT1, GGT5 and 3 moreinner side of the membrane, outer side of the membrane, cytosolOne of 2 routes

1. trans-4-hydroxy-L-proline(out) + L-threonine(in) + Na(+)(out) = trans-4-hydroxy-L-proline(in) + L-threonine(out) + Na(+)(in)
2. trans-4-hydroxy-L-proline + a quinone = (3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + a quinol + H(+)

Catalysed by SLC1A4, PRODH2inner side of the membrane, outer side of the membrane

1. L-threonine = acetaldehyde + glycine
2. 2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde

Catalysed by SHMT1, DERA

1. L-threonine(out) + L-alanine(in) = L-threonine(in) + L-alanine(out)
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

Catalysed by SLC7A10, MOCOSinner side of the membrane, outer side of the membrane

1. L-threonine = acetaldehyde + glycine
2. (2S)-2-aminobutanoate + glyoxylate = 2-oxobutanoate + glycine

Catalysed by SHMT1, AGXT2One of 7 routes

1. L-threonine = 2-oxobutanoate + NH4(+)
2. 2-iminobutanoate + H2O = 2-oxobutanoate + NH4(+)

Catalysed by SDS, SDSL, RIDA

1. L-threonine = acetaldehyde + glycine
2. Glycodeoxycholate amidohydrolase

Catalysed by SHMT1cytosolOne of 2 routes

1. L-threonine = acetaldehyde + glycine
2. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)

Catalysed by SHMT1, GLYATL2

1. L-threonine = acetaldehyde + glycine
2. eicosanoyl-CoA + glycine = N-eicosanoylglycinate + CoA + H(+)

Catalysed by SHMT1, BAAT

1. L-threonine = acetaldehyde + glycine
2. docosanoyl-CoA + glycine = N-docosanoylglycine + CoA + H(+)

Catalysed by SHMT1, BAAT

1. L-threonine = acetaldehyde + glycine
2. hexacosanoyl-CoA + glycine = N-hexacosanoylglycine + CoA + H(+)

Catalysed by SHMT1, BAAT

1. L-threonine(in) + L-glutamine(out) + Na(+)(out) = L-threonine(out) + L-glutamine(in) + Na(+)(in)
2. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)

Catalysed by SLC1A5, GLYATL1B, GLYATL1inner side of the membrane, outer side of the membrane

1. L-threonine = acetaldehyde + glycine
2. transport of glycine and tryptophan (cytosol to extracellular)
3. beta-carboline hydrolysis

Catalysed by SHMT1, SLC7A5extracellular space, cytosol

1. L-threonine = acetaldehyde + glycine
2. bile acid-CoA: amino acid N-acyltransferase
3. Carnitine O-Palmitoyltransferase

Catalysed by SHMT1, BAAT, CPT1A and 1 more