hypotaurine

Three steps

• (9Z,12Z)-octadecadienoyl-CoAReach from here →
  1. hypotaurine + NADPH + O2 + H(+) = taurine + NADP(+) + H2O
  2. Choloyl-CoA:glycine N-choloyltransferase
  3. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)

  Catalysed by FMO3, FMO1, BAAT, SLC27A2 and 7 moreperoxisome, cytosolOne of 13 routes

• tetradecanoyl-CoAReach from here →
  1. hypotaurine + NADPH + O2 + H(+) = taurine + NADP(+) + H2O
  2. Choloyl-CoA:glycine N-choloyltransferase
  3. long-chain-fatty-acid-CoA ligase (myristic acid)

  Catalysed by FMO3, FMO1, BAAT, SLC27A2 and 7 moreperoxisome, cytosolOne of 11 routes

• octanoyl-CoAReach from here →
  1. hypotaurine + NADPH + O2 + H(+) = taurine + NADP(+) + H2O
  2. Choloyl-CoA:glycine N-choloyltransferase
  3. Octanoyl-CoA:L-carnitine O-octanoyltransferase

  Catalysed by FMO3, FMO1, BAAT, CROTperoxisome, mitochondrial matrixOne of 20 routes

• phytanoyl-CoAReach from here →
  1. hypotaurine + NADPH + O2 + H(+) = taurine + NADP(+) + H2O
  2. Choloyl-CoA:glycine N-choloyltransferase
  3. phytanate-CoA ligase

  Catalysed by FMO3, FMO1, BAATperoxisome, cytosolOne of 5 routes

• octadecanoyl-CoAReach from here →
  1. hypotaurine + NADPH + O2 + H(+) = taurine + NADP(+) + H2O
  2. Choloyl-CoA:glycine N-choloyltransferase
  3. long-chain-fatty-acid-CoA ligase (stearate)

  Catalysed by FMO3, FMO1, BAAT, SLC27A2 and 6 moreperoxisome, cytosolOne of 15 routes

• prostaglandin H2Reach from here →
  1. hypotaurine + NADPH + O2 + H(+) = taurine + NADP(+) + H2O
  2. uridine(34) in tRNA + 5,10-methylenetetrahydrofolate + taurine + GTP + A + H2O = 5-taurinomethyluridine(34) in tRNA + 7,8-dihydrofolate + GDP + AH2 + phosphate + H(+)
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + 2 O2 = prostaglandin H2 + A + H2O

  Catalysed by FMO3, FMO1, MTO1, PTGS1 and 1 moreOne of 2 routes

• (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
  1. hypotaurine + NADPH + O2 + H(+) = taurine + NADP(+) + H2O
  2. uridine(34) in tRNA + 5,10-methylenetetrahydrofolate + taurine + GTP + A + H2O = 5-taurinomethyluridine(34) in tRNA + 7,8-dihydrofolate + GDP + AH2 + phosphate + H(+)
  3. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O

  Catalysed by FMO3, FMO1, MTO1, TBXAS1 and 2 more

• (6S)-5,6,7,8-tetrahydrofolateReach from here →
  1. hypotaurine + NADPH + O2 + H(+) = taurine + NADP(+) + H2O
  2. uridine(34) in tRNA + 5,10-methylenetetrahydrofolate + taurine + GTP + A + H2O = 5-taurinomethyluridine(34) in tRNA + 7,8-dihydrofolate + GDP + AH2 + phosphate + H(+)
  3. (6S)-5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + NADPH + H(+)

  Catalysed by FMO3, FMO1, MTO1, DHFR and 1 more

• 2-(N(omega)-L-arginino)succinateReach from here →
  1. 3-sulfino-L-alanine + H(+) = hypotaurine + CO2
  2. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  3. L-Citrulline:L-aspartate ligase (AMP-forming)

  Catalysed by GADL1, CSAD, SLC25A12, SLC25A13 and 1 moremitochondrial matrix, cytosolOne of 2 routes

• N(6)-(1,2-dicarboxyethyl)-AMPReach from here →
  1. 3-sulfino-L-alanine + H(+) = hypotaurine + CO2
  2. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  3. IMP:L-aspartate ligase (GDP-forming)

  Catalysed by GADL1, CSAD, SLC25A12, SLC25A13 and 2 moremitochondrial matrix, cytosolOne of 2 routes

• L-histidineReach from here →
  1. hypotaurine + NADPH + O2 + H(+) = taurine + NADP(+) + H2O
  2. taurine + L-arginine = taurocyamine + L-ornithine
  3. L-histidine(in) + L-ornithine(out) + H(+)(in) = L-histidine(out) + L-ornithine(in) + H(+)(out)

  Catalysed by FMO3, FMO1, GATM, SLC25A2inner side of the membrane, outer side of the membraneOne of 2 routes

• D-ornithineReach from here →
  1. hypotaurine + NADPH + O2 + H(+) = taurine + NADP(+) + H2O
  2. taurine + L-arginine = taurocyamine + L-ornithine
  3. D-ornithine(in) + L-ornithine(out) = D-ornithine(out) + L-ornithine(in)

  Catalysed by FMO3, FMO1, GATM, SLC25A2inner side of the membrane, outer side of the membraneOne of 2 routes

• guanidinoacetateReach from here →
  1. hypotaurine + NADPH + O2 + H(+) = taurine + NADP(+) + H2O
  2. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  3. Transport of Guanidinoacetic Acid

  Catalysed by FMO3, FMO1, SLC6A6extracellular space, cytosol

• sphing-4-enineReach from here →
  1. hypotaurine + NADPH + O2 + H(+) = taurine + NADP(+) + H2O
  2. Choloyl-CoA:glycine N-choloyltransferase
  3. acyl-CoA:sphingosine N-acyltransferase

  Catalysed by FMO3, FMO1, BAAT, ASAH1 and 3 moreperoxisome, Golgi apparatusOne of 2 routes

• spermidineReach from here →
  1. hypotaurine + NADPH + O2 + H(+) = taurine + NADP(+) + H2O
  2. Choloyl-CoA:glycine N-choloyltransferase
  3. diamine N-acetyltransferase (N1-acetylspermidine)

  Catalysed by FMO3, FMO1, BAAT, SAT1 and 1 moreperoxisome, cytosolOne of 3 routes

• L-methionineReach from here →
  1. 3-sulfino-L-alanine + H(+) = hypotaurine + CO2
  2. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  3. L-aspartate(in) + L-methionine(out) = L-aspartate(out) + L-methionine(in)

  Catalysed by GADL1, CSAD, SLC25A12, SLC25A13 and 1 moremitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 11 routes

• L-tryptophanReach from here →
  1. 3-sulfino-L-alanine + H(+) = hypotaurine + CO2
  2. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  3. L-tryptophan(out) + L-aspartate(in) = L-tryptophan(in) + L-aspartate(out)

  Catalysed by GADL1, CSAD, SLC25A12, SLC25A13 and 1 moremitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 6 routes

• glutathioneReach from here →
  1. hypotaurine + NADPH + O2 + H(+) = taurine + NADP(+) + H2O
  2. Choloyl-CoA:glycine N-choloyltransferase
  3. taurocholate(in) + glutathione(in) + ATP + H2O = taurocholate(out) + glutathione(out) + ADP + phosphate + H(+)

  Catalysed by FMO3, FMO1, BAAT, ABCC4peroxisome, inner side of the membrane, outer side of the membraneOne of 3 routes

• beta-alanineReach from here →
  1. 3-sulfino-L-alanine + H(+) = hypotaurine + CO2
  2. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  3. L-aspartate 1-carboxy-lyase (beta-alanine-forming)

  Catalysed by GADL1, CSAD, SLC25A12, SLC25A13 and 1 moremitochondrial matrix, cytosolOne of 4 routes

• L-alanineReach from here →
  1. 3-sulfino-L-alanine + H(+) = hypotaurine + CO2
  2. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  3. oxaloacetate + L-alanine = L-aspartate + pyruvate

  Catalysed by GADL1, CSAD, SLC25A12, SLC25A13 and 1 moremitochondrial matrix, cytosolOne of 9 routes

• L-asparagineReach from here →
  1. 3-sulfino-L-alanine + H(+) = hypotaurine + CO2
  2. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  3. L-aspartate:L-glutamine amido-ligase (AMP-forming)

  Catalysed by GADL1, CSAD, SLC25A12, SLC25A13 and 1 moremitochondrial matrix, cytosolOne of 7 routes

• L-glutamate 5-semialdehydeReach from here →
  1. hypotaurine + NADPH + O2 + H(+) = taurine + NADP(+) + H2O
  2. taurine + L-arginine = taurocyamine + L-ornithine
  3. L-ornithine + 2-oxoglutarate = L-glutamate 5-semialdehyde + L-glutamate

  Catalysed by FMO3, FMO1, GATM, OAT

• N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagineReach from here →
  1. 3-sulfino-L-alanine + H(+) = hypotaurine + CO2
  2. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  3. N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O = N-acetyl-beta-D-glucosaminylamine + L-aspartate + H(+)

  Catalysed by GADL1, CSAD, SLC25A12, SLC25A13 and 1 moremitochondrial matrix, cytosol

• L-phenylalanineReach from here →
  1. 3-sulfino-L-alanine + H(+) = hypotaurine + CO2
  2. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  3. L-aspartate(in) + L-phenylalanine(out) = L-aspartate(out) + L-phenylalanine(in)

  Catalysed by GADL1, CSAD, SLC25A12, SLC25A13 and 1 moremitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 6 routes

• L,L-cystathionineReach from here →
  1. hypotaurine + NADPH + O2 + H(+) = taurine + NADP(+) + H2O
  2. Choloyl-CoA:glycine N-choloyltransferase
  3. N-acetylglutamate synthase (N-acetyl-L-cystathionine)

  Catalysed by FMO3, FMO1, BAAT, NAGSperoxisome, mitochondrial matrix

• taurolithocholate 3-sulfateReach from here →
  1. hypotaurine + NADPH + O2 + H(+) = taurine + NADP(+) + H2O
  2. bile acid-CoA:amino acid N-acyltransferase (lithocholate)
  3. 3'-Phosphoadenylylsulfate:taurolithocholate sulfotransferase

  Catalysed by FMO3, FMO1, BAAT, SULT2A1cytosolOne of 2 routes

• L-tyrosineReach from here →
  1. 3-sulfino-L-alanine + H(+) = hypotaurine + CO2
  2. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  3. L-tyrosine(out) + L-aspartate(in) = L-tyrosine(in) + L-aspartate(out)

  Catalysed by GADL1, CSAD, SLC25A12, SLC25A13 and 1 moremitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• N(omega),N(omega)-dimethyl-L-arginineReach from here →
  1. 3-sulfino-L-alanine + H(+) = hypotaurine + CO2
  2. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  3. N(omega),N(omega)-dimethyl-L-arginine + oxaloacetate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-aspartate

  Catalysed by GADL1, CSAD, SLC25A12, SLC25A13 and 1 moremitochondrial matrix, cytosolOne of 3 routes

• an acyl-CoAReach from here →
  1. hypotaurine + NADPH + O2 + H(+) = taurine + NADP(+) + H2O
  2. Choloyl-CoA:glycine N-choloyltransferase
  3. acyl-CoA:sphingosine N-acyltransferase

  Catalysed by FMO3, FMO1, BAAT, ASAH1 and 3 moreperoxisome, Golgi apparatusOne of 2 routes

• (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinateReach from here →
  1. 3-sulfino-L-alanine + H(+) = hypotaurine + CO2
  2. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  3. 1-(5-Phosphoribosyl)-5-amino-4-carboxyimidazole:L-aspartate ligase (ADP-forming)

  Catalysed by GADL1, CSAD, SLC25A12, SLC25A13 and 1 moremitochondrial matrix, cytosolOne of 2 routes

• (3Z)-dodecenoyl-CoAReach from here →
  1. hypotaurine + NADPH + O2 + H(+) = taurine + NADP(+) + H2O
  2. Choloyl-CoA:glycine N-choloyltransferase
  3. acetyl-CoA C-acyltransferase (3-oxomyrist-5-enoyl-CoA)

  Catalysed by FMO3, FMO1, BAAT, HADHA and 2 moreperoxisome, mitochondrial matrixOne of 3 routes

• (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoAReach from here →
  1. hypotaurine + NADPH + O2 + H(+) = taurine + NADP(+) + H2O
  2. Choloyl-CoA:glycine N-choloyltransferase
  3. 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate:CoA ligase (AMP-forming)

  Catalysed by FMO3, FMO1, BAAT, SLC27A2 and 1 moreperoxisome, endoplasmic reticulumOne of 3 routes

• 5-amino-2-oxopentanoateReach from here →
  1. hypotaurine + NADPH + O2 + H(+) = taurine + NADP(+) + H2O
  2. taurine + L-arginine = taurocyamine + L-ornithine
  3. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine

  Catalysed by FMO3, FMO1, GATM, AGXT2One of 2 routes

• deoxycholoyl-CoAReach from here →
  1. hypotaurine + NADPH + O2 + H(+) = taurine + NADP(+) + H2O
  2. Choloyl-CoA:glycine N-choloyltransferase
  3. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)

  Catalysed by FMO3, FMO1, BAAT, SLC27A2 and 1 moreperoxisome, cytosolOne of 6 routes

• 4-aminobutanoateReach from here →
  1. hypotaurine + NADPH + O2 + H(+) = taurine + NADP(+) + H2O
  2. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  3. transport of 4-aminobutyrate and chloride (cytosol to extracellular)

  Catalysed by FMO3, FMO1, SLC6A6, SLC6A12extracellular space, cytosolOne of 4 routes

• decanoyl-CoAReach from here →
  1. hypotaurine + NADPH + O2 + H(+) = taurine + NADP(+) + H2O
  2. Choloyl-CoA:glycine N-choloyltransferase
  3. medium-chain acyl-CoA ligase (decanoic acid)

  Catalysed by FMO3, FMO1, BAAT, ACSM4 and 5 moreperoxisome, cytosolOne of 7 routes

• (2E)-hexadecenoyl-CoAReach from here →
  1. hypotaurine + NADPH + O2 + H(+) = taurine + NADP(+) + H2O
  2. Choloyl-CoA:glycine N-choloyltransferase
  3. Carnitine O-Palmitoyltransferase

  Catalysed by FMO3, FMO1, BAAT, CPT1A and 2 moreperoxisome, cytosolOne of 4 routes

• (9Z)-hexadecenoyl-CoAReach from here →
  1. hypotaurine + NADPH + O2 + H(+) = taurine + NADP(+) + H2O
  2. Choloyl-CoA:glycine N-choloyltransferase
  3. long-chain-fatty-acid-CoA ligase (palmitolate)

  Catalysed by FMO3, FMO1, BAAT, SLC27A2 and 7 moreperoxisome, cytosolOne of 11 routes

• 3-hydroxyisovaleryl-CoAReach from here →
  1. hypotaurine + NADPH + O2 + H(+) = taurine + NADP(+) + H2O
  2. Choloyl-CoA:glycine N-choloyltransferase
  3. (3-Hydroxyisovalerylcoa->3-Hydroxyisovalerylcarnitine)

  Catalysed by FMO3, FMO1, BAAT, CPT1A and 1 moreperoxisome, cytosol

• CHEBI:63544Reach from here →
  1. hypotaurine + NADPH + O2 + H(+) = taurine + NADP(+) + H2O
  2. Choloyl-CoA:glycine N-choloyltransferase
  3. long-chain-fatty-acid-CoA ligase (adrenic acid)

  Catalysed by FMO3, FMO1, BAAT, SLC27A2 and 7 moreperoxisome, cytosolOne of 7 routes

• hexacosanoyl-CoAReach from here →
  1. hypotaurine + NADPH + O2 + H(+) = taurine + NADP(+) + H2O
  2. Choloyl-CoA:glycine N-choloyltransferase
  3. long-chain-fatty-acid-CoA ligase (cerotic acid)

  Catalysed by FMO3, FMO1, BAAT, SLC27A2 and 7 moreperoxisome, cytosolOne of 5 routes

• tetracosanoyl-CoAReach from here →
  1. hypotaurine + NADPH + O2 + H(+) = taurine + NADP(+) + H2O
  2. Choloyl-CoA:glycine N-choloyltransferase
  3. long-chain-fatty-acid-CoA ligase (lignocerate)

  Catalysed by FMO3, FMO1, BAAT, SLC27A2 and 7 moreperoxisome, cytosolOne of 10 routes

• docosanoyl-CoAReach from here →
  1. hypotaurine + NADPH + O2 + H(+) = taurine + NADP(+) + H2O
  2. Choloyl-CoA:glycine N-choloyltransferase
  3. long-chain-fatty-acid-CoA ligase (behenic acid)

  Catalysed by FMO3, FMO1, BAAT, SLC27A2 and 7 moreperoxisome, cytosolOne of 9 routes

• a 2,3-saturated acyl-CoAReach from here →
  1. hypotaurine + NADPH + O2 + H(+) = taurine + NADP(+) + H2O
  2. uridine(34) in tRNA + 5,10-methylenetetrahydrofolate + taurine + GTP + A + H2O = 5-taurinomethyluridine(34) in tRNA + 7,8-dihydrofolate + GDP + AH2 + phosphate + H(+)
  3. a 2,3-saturated acyl-CoA + A = a 2,3-dehydroacyl-CoA + AH2

  Catalysed by FMO3, FMO1, MTO1, ACAD10

• (2E)-octadecenoyl-CoAReach from here →
  1. hypotaurine + NADPH + O2 + H(+) = taurine + NADP(+) + H2O
  2. Choloyl-CoA:glycine N-choloyltransferase
  3. Carnitine O-Palmitoyltransferase

  Catalysed by FMO3, FMO1, BAAT, CPT1A and 2 moreperoxisome, cytosolOne of 3 routes

• (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoAReach from here →
  1. hypotaurine + NADPH + O2 + H(+) = taurine + NADP(+) + H2O
  2. Choloyl-CoA:glycine N-choloyltransferase
  3. long-chain-fatty-acid-CoA ligase (stearidonic acid)

  Catalysed by FMO3, FMO1, BAAT, SLC27A2 and 7 moreperoxisome, cytosolOne of 8 routes

• (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoAReach from here →
  1. hypotaurine + NADPH + O2 + H(+) = taurine + NADP(+) + H2O
  2. Choloyl-CoA:glycine N-choloyltransferase
  3. long-chain-fatty-acid-CoA ligase (EPA)

  Catalysed by FMO3, FMO1, BAAT, SLC27A2 and 7 moreperoxisome, cytosolOne of 9 routes

• (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoAReach from here →
  1. hypotaurine + NADPH + O2 + H(+) = taurine + NADP(+) + H2O
  2. Choloyl-CoA:glycine N-choloyltransferase
  3. long-chain-fatty-acid-CoA ligase (DPA)

  Catalysed by FMO3, FMO1, BAAT, SLC27A2 and 7 moreperoxisome, cytosolOne of 6 routes

• (9Z,12Z,15Z)-octadecatrienoyl-CoAReach from here →
  1. hypotaurine + NADPH + O2 + H(+) = taurine + NADP(+) + H2O
  2. Choloyl-CoA:glycine N-choloyltransferase
  3. long-chain-fatty-acid-CoA ligase (linolenate)

  Catalysed by FMO3, FMO1, BAAT, SLC27A2 and 7 moreperoxisome, cytosolOne of 7 routes

• (13Z)-docosenoyl-CoAReach from here →
  1. hypotaurine + NADPH + O2 + H(+) = taurine + NADP(+) + H2O
  2. Choloyl-CoA:glycine N-choloyltransferase
  3. long-chain-fatty-acid-CoA ligase (cis-erucic acid)

  Catalysed by FMO3, FMO1, BAAT, SLC27A2 and 7 moreperoxisome, cytosolOne of 6 routes