L-lysine

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

353 compounds within 3 steps: 7 in 1, 60 in 2, 286 in 3

Two steps

L-methionineReach from here →
1. L-ornithine(out) + L-lysine(in) = L-ornithine(in) + L-lysine(out)
2. transport of methionine and ornithine (cytosol to extracellular)
Catalysed by SLC25A2, SLC25A15, SLC7A6inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 13 routes
L-tryptophanReach from here →
1. L-ornithine(out) + L-lysine(in) = L-ornithine(in) + L-lysine(out)
2. transport of ornithine and tryptophan (cytosol to extracellular)
Catalysed by SLC25A2, SLC25A15, SLC7A6inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 8 routes
L-kynurenineReach from here →
1. L-lysine(in) + L-leucine(out) + Na(+)(out) = L-lysine(out) + L-leucine(in) + Na(+)(in)
2. Transport of L-Kynurenine
Catalysed by SLC7A7, SLC43A1inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes
L-alanineReach from here →
1. L-ornithine(out) + L-lysine(in) = L-ornithine(in) + L-lysine(out)
2. transport of alanine and ornithine (cytosol to extracellular)
Catalysed by SLC25A2, SLC25A15, SLC7A6inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 11 routes
dimethylamineReach from here →
1. N(omega),N(omega)-dimethyl-L-arginine(in) + L-lysine(out) = N(omega),N(omega)-dimethyl-L-arginine(out) + L-lysine(in)
2. Nomega,Nomega'-dimethyl-L-arginine dimethylamidohydrolase
Catalysed by SLC25A2, DDAH1inner side of the membrane, outer side of the membrane, cytosolOne of 2 routes
L-asparagineReach from here →
1. L-ornithine(out) + L-lysine(in) = L-ornithine(in) + L-lysine(out)
2. transport of asparagine and ornithine (cytosol to extracellular)
Catalysed by SLC25A2, SLC25A15, SLC7A6inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 7 routes
taurocyamineReach from here →
1. L-lysine(out) + L-arginine(in) = L-lysine(in) + L-arginine(out)
2. taurine + L-arginine = taurocyamine + L-ornithine
Catalysed by SLC7A9, SLC25A29, SLC7A6, GATMinner side of the membrane, outer side of the membrane
L-glutamate 5-semialdehydeReach from here →
1. L-ornithine(out) + L-lysine(in) = L-ornithine(in) + L-lysine(out)
2. L-ornithine + 2-oxoglutarate = L-glutamate 5-semialdehyde + L-glutamate
Catalysed by SLC25A2, SLC25A15, OATinner side of the membrane, outer side of the membrane
L-phenylalanineReach from here →
1. L-ornithine(out) + L-lysine(in) = L-ornithine(in) + L-lysine(out)
2. transport of ornithine and phenylalanine (cytosol to extracellular)
Catalysed by SLC25A2, SLC25A15, SLC7A6inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 12 routes
(S)-2-amino-6-oxohexanoateReach from here →
1. L-saccharopine + NADP(+) + H2O = L-lysine + 2-oxoglutarate + NADPH + H(+)
2. L-saccharopine + NAD(+) + H2O = (S)-2-amino-6-oxohexanoate + L-glutamate + NADH + H(+)
Catalysed by AASS
5-oxo-L-prolineReach from here →
1. epsilon-(gamma-L-glutamyl)-L-lysine = 5-oxo-L-proline + L-lysine
2. epsilon-(gamma-L-glutamyl)-L-lysine = 5-oxo-L-proline + L-lysine
Catalysed by GGACT
L-2-aminopentanoateReach from here →
1. N(omega),N(omega)-dimethyl-L-arginine(in) + L-lysine(out) = N(omega),N(omega)-dimethyl-L-arginine(out) + L-lysine(in)
2. 2-oxopentanoate + N(omega),N(omega)-dimethyl-L-arginine = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-2-aminopentanoate
Catalysed by SLC25A2, AGXT2inner side of the membrane, outer side of the membrane
L-2-aminohexanoateReach from here →
1. N(omega),N(omega)-dimethyl-L-arginine(in) + L-lysine(out) = N(omega),N(omega)-dimethyl-L-arginine(out) + L-lysine(in)
2. 2-oxohexanoate + N(omega),N(omega)-dimethyl-L-arginine = L-2-aminohexanoate + 5-(3,3-dimethylguanidino)-2-oxopentanoate
Catalysed by SLC25A2, AGXT2inner side of the membrane, outer side of the membrane
5-guanidino-2-oxopentanoateReach from here →
1. L-lysine(out) + L-arginine(in) = L-lysine(in) + L-arginine(out)
2. L-arginine + O2 + H2O = 5-guanidino-2-oxopentanoate + H2O2 + NH4(+)
Catalysed by SLC7A9, SLC25A29, SLC7A6, IL4I1inner side of the membrane, outer side of the membrane
5-amino-2-oxopentanoateReach from here →
1. L-ornithine(out) + L-lysine(in) = L-ornithine(in) + L-lysine(out)
2. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
Catalysed by SLC25A2, SLC25A15, AGXT2inner side of the membrane, outer side of the membraneOne of 2 routes
N(5)-[(Z)-amino(hydroxyimino)methyl]ornithineReach from here →
1. L-lysine(out) + L-arginine(in) = L-lysine(in) + L-arginine(out)
2. L-arginine,NADPH:oxygen oxidoreductase (N-(omega)-hydroxyarginine-forming)
Catalysed by SLC7A9, SLC25A29, SLC7A6, NOS3 and 2 moreinner side of the membrane, outer side of the membrane, cytosol
(2S)-2-aminobutanoateReach from here →
1. N(omega),N(omega)-dimethyl-L-arginine(in) + L-lysine(out) = N(omega),N(omega)-dimethyl-L-arginine(out) + L-lysine(in)
2. N(omega),N(omega)-dimethyl-L-arginine + 2-oxobutanoate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + (2S)-2-aminobutanoate
Catalysed by SLC25A2, AGXT2inner side of the membrane, outer side of the membrane

Three steps

beta-carbolineReach from here →
Catalysed by SLC25A2, SLC25A15, SLC7A6inner side of the membrane, outer side of the membrane, extracellular space, cytosol
(S)-carnitineReach from here →
Catalysed by