phosphocholine

Three steps

• thyronamineReach from here →
  1. phosphocholine + H2O = choline + phosphate
  2. choline + A = betaine aldehyde + AH2
  3. thyronamine + iodide + A + H(+) = 3-iodothyronamine + AH2

  Catalysed by PHOSPHO1, CHDH, DIO3

• 3'-iodothyronamineReach from here →
  1. phosphocholine + H2O = choline + phosphate
  2. choline + A = betaine aldehyde + AH2
  3. 3'-iodothyronamine + iodide + A + H(+) = 3',5'-diiodothyronamine + AH2

  Catalysed by PHOSPHO1, CHDH, DIO1, DIO2One of 2 routes

• 3,3'-diiodothyronamineReach from here →
  1. phosphocholine + H2O = choline + phosphate
  2. choline + A = betaine aldehyde + AH2
  3. 3,3'-diiodothyronamine + iodide + A + H(+) = 3,3',5'-triiodothyronamine + AH2

  Catalysed by PHOSPHO1, CHDH, DIO1, DIO2One of 2 routes

• 3',5'-diiodothyronamineReach from here →
  1. phosphocholine + H2O = choline + phosphate
  2. choline + A = betaine aldehyde + AH2
  3. 3',5'-diiodothyronamine + iodide + A + H(+) = 3,3',5'-triiodothyronamine + AH2

  Catalysed by PHOSPHO1, CHDH, DIO3

• 3,3',5'-triiodothyronamineReach from here →
  1. phosphocholine + H2O = choline + phosphate
  2. choline + A = betaine aldehyde + AH2
  3. 3,3',5'-triiodothyronamine + iodide + A + H(+) = 3,3',5,5'-tetraiodothyronamine + AH2

  Catalysed by PHOSPHO1, CHDH, DIO3

• (4Z,7Z,10Z,13Z)-hexadecatetraenoyl-CoAReach from here →
  1. phosphocholine + H2O = choline + phosphate
  2. Acetyl-CoA:choline O-acetyltransferase
  3. Fatty Acid Beta Oxidation (C18:4->C16:4), Mitochondrial

  Catalysed by PHOSPHO1, CHAT, HADHA, ACADVL and 1 morecytosol, mitochondrial matrixOne of 3 routes

• (7Z,10Z)-hexadecadienoyl-CoAReach from here →
  1. phosphocholine + H2O = choline + phosphate
  2. Acetyl-CoA:choline O-acetyltransferase
  3. Fatty Acid Beta Oxidation Trans (C18:2->C16:2), Mitochondrial

  Catalysed by PHOSPHO1, CHAT, HADHA, ACADVL and 1 morecytosol, mitochondrial matrix

• (4Z,7Z)-decadienoyl-CoAReach from here →
  1. phosphocholine + H2O = choline + phosphate
  2. Acetyl-CoA:choline O-acetyltransferase
  3. Fatty Acid Beta Oxidation (C12:3->C10:2), Mitochondrial

  Catalysed by PHOSPHO1, CHAT, ECHS1, ACAA2 and 1 morecytosol, mitochondrial matrixOne of 2 routes

• (5Z)-octenoyl-CoAReach from here →
  1. phosphocholine + H2O = choline + phosphate
  2. Acetyl-CoA:choline O-acetyltransferase
  3. Fatty Acid Beta Oxidation (C10:2->C8:1), Mitochondrial

  Catalysed by PHOSPHO1, CHAT, ECHS1, ACAA2 and 1 morecytosol, mitochondrial matrixOne of 2 routes

• CHEBI:240943Reach from here →
  1. phosphocholine + H2O = choline + phosphate
  2. transport of chloride and choline (cytosol to extracellular)
  3. 2-Methylbutyrylglycine Transport, Extracellular

  Catalysed by PHOSPHO1, SLC5A7, SLC6A5extracellular space, cytosolOne of 2 routes

• hypochlorous acidReach from here →
  1. phosphocholine + H2O = choline + phosphate
  2. transport of chloride and choline (cytosol to extracellular)
  3. Peroxidase

  Catalysed by PHOSPHO1, SLC5A7, LPOextracellular space, cytosolOne of 4 routes

• potassium atomReach from here →
  1. phosphocholine + H2O = choline + phosphate
  2. transport of chloride and choline (cytosol to extracellular)
  3. transport of chloride (cytosol to extracellular)

  Catalysed by PHOSPHO1, SLC5A7, SLC12A2, SLC12A1extracellular space, cytosolOne of 2 routes

• CHEBI:27540Reach from here →
  1. phosphocholine + H2O = choline + phosphate
  2. Acetyl-CoA:choline O-acetyltransferase
  3. medium-chain acyl-CoA ligase (hexanoic acid)

  Catalysed by PHOSPHO1, CHAT, ACSM4, ACSM1 and 4 morecytosolOne of 6 routes

• elaidic acidReach from here →
  1. phosphocholine + H2O = choline + phosphate
  2. Acetyl-CoA:choline O-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (elaidate)

  Catalysed by PHOSPHO1, CHAT, SLC27A2, ACSL4 and 6 morecytosolOne of 5 routes

• all-cis-docosa-4,7,10,13,16,19-hexaenoic acidReach from here →
  1. phosphocholine + CTP + H(+) = CDP-choline + diphosphate
  2. 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + CDP-choline = 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)
  3. 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H2O = (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)

  Catalysed by PCYT1A, PCYT1B, CHPT1, CEPT1 and 3 more

• 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholineReach from here →
  1. phosphocholine + CTP + H(+) = CDP-choline + diphosphate
  2. CDP-choline + 1,2-di-(9Z-octadecenoyl)-sn-glycerol = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)
  3. 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine

  Catalysed by PCYT1A, PCYT1B, CEPT1, PLA2G15One of 3 routes

• CHEBI:28701Reach from here →
  1. phosphocholine + H2O = choline + phosphate
  2. Acetyl-CoA:choline O-acetyltransferase
  3. Propanoyl-CoA:acetyl-CoA C-acyltransferase

  Catalysed by PHOSPHO1, CHAT, ACAA1, SCP2 and 1 morecytosol, peroxisomeOne of 7 routes

• a fatty acidReach from here →
  1. phosphocholine + CTP + H(+) = CDP-choline + diphosphate
  2. CDP-choline + a 1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phosphocholine + CMP + H(+)
  3. a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)

  Catalysed by PCYT1A, PCYT1B, CHPT1, CEPT1 and 30 moreOne of 5 routes

• a carboxylateReach from here →
  1. phosphocholine + H2O = choline + phosphate
  2. an acylcholine + H2O = a carboxylate + choline + H(+)
  3. an acylcholine + H2O = a carboxylate + choline + H(+)

  Catalysed by PHOSPHO1, BCHE

• hydrogenselenideReach from here →
  1. phosphocholine + H2O = choline + phosphate
  2. choline + A = betaine aldehyde + AH2
  3. L-selenocysteine + AH2 = hydrogenselenide + L-alanine + A + H(+)

  Catalysed by PHOSPHO1, CHDH, SCLY

• acetateReach from here →
  1. phosphocholine + H2O = choline + phosphate
  2. Acetyl-CoA:choline O-acetyltransferase
  3. Acetylcholine aectylhydrolase

  Catalysed by PHOSPHO1, CHAT, BCHE, ACHEcytosolOne of 4 routes

• formic acidReach from here →
  1. phosphocholine + H2O = choline + phosphate
  2. transport of chloride and choline (cytosol to extracellular)
  3. transport of chloride and formate (cytosol to extracellular)

  Catalysed by PHOSPHO1, SLC5A7, SLC26A4extracellular space, cytosolOne of 2 routes

• malonic acidReach from here →
  1. phosphocholine + H2O = choline + phosphate
  2. transport of chloride and choline (cytosol to extracellular)
  3. Malonate Transport, Antiport with Chloride

  Catalysed by PHOSPHO1, SLC5A7extracellular space, cytosolOne of 2 routes

• (9Z)-octadecenoateReach from here →
  1. phosphocholine + CTP + H(+) = CDP-choline + diphosphate
  2. CDP-choline + 1,2-di-(9Z-octadecenoyl)-sn-glycerol = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)
  3. 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + (9Z)-octadecenoate + H(+)

  Catalysed by PCYT1A, PCYT1B, CEPT1, DDHD2 and 3 moreOne of 4 routes

• a 1-O-alkyl-sn-glycero-3-phosphocholineReach from here →
  1. phosphocholine + CTP + H(+) = CDP-choline + diphosphate
  2. 1-O-alkyl-2-acyl-sn-glycerol + CDP-choline = a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + CMP + H(+)
  3. a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)

  Catalysed by PCYT1A, PCYT1B, CEPT1, PLA2G6 and 5 moreOne of 2 routes

• (5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. phosphocholine + CTP + H(+) = CDP-choline + diphosphate
  2. 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + CDP-choline = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)
  3. 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)

  Catalysed by PCYT1A, PCYT1B, CHPT1, PLA2G10 and 2 moreOne of 2 routes

• fatty acidReach from here →
  1. phosphocholine + CTP + H(+) = CDP-choline + diphosphate
  2. 1-O-alkyl-2-acyl-sn-glycerol + CDP-choline = a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + CMP + H(+)
  3. plasmanylcholine 2-acylhydrolase

  Catalysed by PCYT1A, PCYT1B, CEPT1, PLA2G10 and 17 morecytosolOne of 2 routes

• a sterol esterReach from here →
  1. phosphocholine + CTP + H(+) = CDP-choline + diphosphate
  2. CDP-choline + a 1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phosphocholine + CMP + H(+)
  3. a sterol + a 1,2-diacyl-sn-glycero-3-phosphocholine = a sterol ester + a 1-acyl-sn-glycero-3-phosphocholine

  Catalysed by PCYT1A, PCYT1B, CHPT1, CEPT1 and 1 more

• 25-hydroxycholesterolReach from here →
  1. phosphocholine + H2O = choline + phosphate
  2. choline + A = betaine aldehyde + AH2
  3. cholesterol + AH2 + O2 = 25-hydroxycholesterol + A + H2O

  Catalysed by PHOSPHO1, CHDH, CH25H

• cholesteryl (9Z-octadecenoate)Reach from here →
  1. phosphocholine + CTP + H(+) = CDP-choline + diphosphate
  2. 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CDP-choline = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)
  3. 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + cholesterol = cholesteryl (9Z-octadecenoate) + 1-hexadecanoyl-sn-glycero-3-phosphocholine

  Catalysed by PCYT1A, PCYT1B, CHPT1, CEPT1 and 1 more

• N-(acetyl)-sphing-4-enineReach from here →
  1. phosphocholine + CTP + H(+) = CDP-choline + diphosphate
  2. 1-O-hexadecyl-2-acetyl-sn-glycerol + CDP-choline = 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + CMP + H(+)
  3. 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)

  Catalysed by PCYT1A, PCYT1B, CEPT1, PAFAH2

• a 1,3-diacylglycerolReach from here →
  1. phosphocholine + CTP + H(+) = CDP-choline + diphosphate
  2. CDP-choline + a 1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phosphocholine + CMP + H(+)
  3. a 3-acyl-sn-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = a 1,3-diacylglycerol + a 1-acyl-sn-glycero-3-phosphocholine

  Catalysed by PCYT1A, PCYT1B, CHPT1, CEPT1 and 1 moreOne of 4 routes

• a 1,2-diacylglycerolReach from here →
  1. phosphocholine + CTP + H(+) = CDP-choline + diphosphate
  2. CDP-choline + a 1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phosphocholine + CMP + H(+)
  3. a 2-acylglycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = a 1,2-diacylglycerol + a 1-acyl-sn-glycero-3-phosphocholine

  Catalysed by PCYT1A, PCYT1B, CHPT1, CEPT1 and 1 moreOne of 2 routes

• taurineReach from here →
  1. phosphocholine + H2O = choline + phosphate
  2. Acetyl-CoA:choline O-acetyltransferase
  3. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)

  Catalysed by PHOSPHO1, CHAT, BAATcytosolOne of 4 routes

• all-trans-13,14-dihydroretinolReach from here →
  1. phosphocholine + H2O = choline + phosphate
  2. choline + A = betaine aldehyde + AH2
  3. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2

  Catalysed by PHOSPHO1, CHDH, RETSAT

• 3,3',5-triiodo-L-thyronineReach from here →
  1. phosphocholine + H2O = choline + phosphate
  2. choline + A = betaine aldehyde + AH2
  3. 3,3',5-triiodo-L-thyronine + iodide + A + H(+) = L-thyroxine + AH2

  Catalysed by PHOSPHO1, CHDH, DIO1, DIO2

• 3,3',5'-triiodo-L-thyronineReach from here →
  1. phosphocholine + H2O = choline + phosphate
  2. choline + A = betaine aldehyde + AH2
  3. 3,3',5'-triiodo-L-thyronine + iodide + A + H(+) = L-thyroxine + AH2

  Catalysed by PHOSPHO1, CHDH, DIO1, DIO3

• a 1,2-diacyl-sn-glycero-3-phospho-L-serineReach from here →
  1. phosphocholine + CTP + H(+) = CDP-choline + diphosphate
  2. CDP-choline + a 1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phosphocholine + CMP + H(+)
  3. a 1,2-diacyl-sn-glycero-3-phosphocholine + L-serine = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + choline

  Catalysed by PCYT1A, PCYT1B, CHPT1, CEPT1 and 1 more

• glycineReach from here →
  1. phosphocholine + H2O = choline + phosphate
  2. Acetyl-CoA:choline O-acetyltransferase
  3. glycine N-acyltransferase (N-arachidonoylglycine)

  Catalysed by PHOSPHO1, CHAT, GLYAT, GLYATL2 and 1 morecytosol, mitochondrial matrixOne of 13 routes

• (R)-methylmalonyl-CoAReach from here →
  1. phosphocholine + H2O = choline + phosphate
  2. Acetyl-CoA:choline O-acetyltransferase
  3. aldehyde dehydrogenase (2-methyl-3-oxopropanoate)

  Catalysed by PHOSPHO1, CHAT, ALDH6A1cytosol, mitochondrial matrixOne of 2 routes

• (S)-methylmalonyl-CoAReach from here →
  1. phosphocholine + H2O = choline + phosphate
  2. Acetyl-CoA:choline O-acetyltransferase
  3. (S)-methylmalonyl-CoA hydrolase

  Catalysed by PHOSPHO1, CHATcytosol, mitochondrial matrix

• 3'-dephospho-CoAReach from here →
  1. phosphocholine + H2O = choline + phosphate
  2. Acetyl-CoA:choline O-acetyltransferase
  3. acid phosphatase 2, lysosomal (CoA)

  Catalysed by PHOSPHO1, CHAT, ACP2cytosol, lysosomeOne of 2 routes

• (2E)-dodecenoyl-CoAReach from here →
  1. phosphocholine + H2O = choline + phosphate
  2. Acetyl-CoA:choline O-acetyltransferase
  3. (2E)-dodecenoyl-CoA formation

  Catalysed by PHOSPHO1, CHATcytosol, mitochondrial matrixOne of 3 routes

• 4,8,12-trimethyltridecanoyl-CoAReach from here →
  1. phosphocholine + H2O = choline + phosphate
  2. Acetyl-CoA:choline O-acetyltransferase
  3. propanoyl-CoA C-acyltransferase (3-ketopristanoyl-CoA)

  Catalysed by PHOSPHO1, CHAT, ACAA1, MYO5Bcytosol, peroxisomeOne of 2 routes

• (6Z,9Z,12Z)-octadecatrienoyl-CoAReach from here →
  1. phosphocholine + H2O = choline + phosphate
  2. Acetyl-CoA:choline O-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (gamma-linolenate)

  Catalysed by PHOSPHO1, CHAT, SLC27A2, ACSL4 and 6 morecytosolOne of 7 routes

• butanoyl-CoAReach from here →
  1. phosphocholine + H2O = choline + phosphate
  2. Acetyl-CoA:choline O-acetyltransferase
  3. Butanoate:CoA ligase (AMP-forming)

  Catalysed by PHOSPHO1, CHAT, ACSM4, ACSM1 and 4 morecytosolOne of 9 routes

• dodecanoyl-CoAReach from here →
  1. phosphocholine + H2O = choline + phosphate
  2. Acetyl-CoA:choline O-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (lauric acid)

  Catalysed by PHOSPHO1, CHAT, SLC27A2, ACSL4 and 6 morecytosolOne of 9 routes

• glutaryl-CoAReach from here →
  1. phosphocholine + H2O = choline + phosphate
  2. Acetyl-CoA:choline O-acetyltransferase
  3. Production of Glutaryl Carnitine

  Catalysed by PHOSPHO1, CHAT, CPT1A, CPT1C and 1 morecytosolOne of 2 routes

• hexadecanoyl-CoAReach from here →
  1. phosphocholine + CTP + H(+) = CDP-choline + diphosphate
  2. 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CDP-choline = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)
  3. 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA

  Catalysed by PCYT1A, PCYT1B, CHPT1, CEPT1 and 1 more

• eicosanoyl-CoAReach from here →
  1. phosphocholine + H2O = choline + phosphate
  2. Acetyl-CoA:choline O-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (eicosanoate)

  Catalysed by PHOSPHO1, CHAT, SLC27A2, ACSL4 and 6 morecytosolOne of 12 routes