a triacylglycerol

Three steps

• 13-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. triacylglycerol acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. unspecific monooxygenase (arachidonate)

  Catalysed by LPL, CYP1A1, CYP1A2, CYP2E1 and 23 moreextracellular space, cytosolOne of 2 routes

• 13(S)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. triacylglycerol acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = 13(S)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by LPL, CYP2C9extracellular space

• 16(R)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. triacylglycerol acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. unspecific monooxygenase (arachidonate)

  Catalysed by LPL, CYP1A1, CYP1A2, CYP2E1 and 23 moreextracellular space, cytosol

• 11-cis-retinyl tetradecanoateReach from here →
  1. a triacylglycerol + all-trans-retinol = an all-trans-retinyl ester + a diacylglycerol
  2. all-trans-retinyl ester acylhydrolase, 11-cis-retinol forming
  3. 11-cis-retinol + tetradecanoyl-CoA = 11-cis-retinyl tetradecanoate + CoA

  Catalysed by PNPLA4, PNPLA2, RPE65, AWAT2cytosol

• all-trans-retinyl tetradecanoateReach from here →
  1. a triacylglycerol + all-trans-retinol = an all-trans-retinyl ester + a diacylglycerol
  2. carboxylesterase (retinyl-ester)
  3. all-trans-retinol + tetradecanoyl-CoA = all-trans-retinyl tetradecanoate + CoA

  Catalysed by PNPLA4, PNPLA2, CES2, RBP4 and 17 morecytosol

• an N-acyl-sphinga-4E,14Z-dienineReach from here →
  1. triacylglycerol acylhydrolase
  2. an N-acylsphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol
  3. an N-acylsphing-4-enine + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = an N-acyl-sphinga-4E,14Z-dienine + 2 Fe(III)-[cytochrome b5] + 2 H2O

  Catalysed by LPL, SGMS1, SGMS2, FADS3extracellular space

• a 3-hydroxyacyl derivative of bacterial toxinReach from here →
  1. a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)
  2. a 3-(acyloxy)acyl derivative of bacterial toxin + H2O = a 3-hydroxyacyl derivative of bacterial toxin + a fatty acid + H(+)
  3. a 3-(acyloxy)acyl derivative of bacterial toxin + H2O = a 3-hydroxyacyl derivative of bacterial toxin + a fatty acid + H(+)

  Catalysed by DDHD2, LPL, LIPF, ABHD2 and 16 more

• a 2-acyl-6-alpha-D-glucosaminyl-1-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositolReach from here →
  1. a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)
  2. a fatty acid + ATP + CoA = a fatty acyl-CoA + AMP + diphosphate
  3. a 6-(alpha-D-glucosaminyl)-1-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol + a fatty acyl-CoA = a 2-acyl-6-alpha-D-glucosaminyl-1-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol + CoA

  Catalysed by DDHD2, LPL, LIPF, ABHD2 and 17 more

• a 2-acyl-6-[alpha-D-mannosyl-(1->6)-2-phosphoethanolamine-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositolReach from here →
  1. triacylglycerol acylhydrolase
  2. CDP-ethanolamine + a 1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CMP + H(+)
  3. a 2-acyl-6-[alpha-D-mannosyl-(1->6)-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = a 2-acyl-6-[alpha-D-mannosyl-(1->6)-2-phosphoethanolamine-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol + a 1,2-diacyl-sn-glycerol

  Catalysed by LPL, SELENOI, CEPT1, PIGNextracellular space

• a 2-acyl-6-[2-phosphoethanolamine-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositolReach from here →
  1. triacylglycerol acylhydrolase
  2. CDP-ethanolamine + a 1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CMP + H(+)
  3. a 2-acyl-6-(alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl)-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = a 2-acyl-6-[2-phosphoethanolamine-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol + a 1,2-diacyl-sn-glycerol

  Catalysed by LPL, SELENOI, CEPT1, PIGNextracellular space

• a 2-acyl-6-[6-phosphoethanolamine-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(1->6)-2-phosphoethanolamine-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositolReach from here →
  1. triacylglycerol acylhydrolase
  2. CDP-ethanolamine + a 1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CMP + H(+)
  3. a 2-acyl-6-[alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(1->6)-2-phosphoethanolamine-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = a 2-acyl-6-[6-phosphoethanolamine-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(1->6)-2-phosphoethanolamine-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol + a 1,2-diacyl-sn-glycerol

  Catalysed by LPL, SELENOI, CEPT1, PIGOextracellular space

• a 2-acyl-6-[6-phosphoethanolamine-alpha-D-mannosyl-(1->2)-6-phosphoethanolamine-alpha-D-mannosyl-(1->6)-2-phosphoethanolamine-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositolReach from here →
  1. triacylglycerol acylhydrolase
  2. CDP-ethanolamine + a 1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CMP + H(+)
  3. a 2-acyl-6-[6-phosphoethanolamine-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(1->6)-2-phosphoethanolamine-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = a 2-acyl-6-[6-phosphoethanolamine-alpha-D-mannosyl-(1->2)-6-phosphoethanolamine-alpha-D-mannosyl-(1->6)-2-phosphoethanolamine-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol + a 1,2-diacyl-sn-glycerol

  Catalysed by LPL, SELENOI, CEPT1, PIGGextracellular space

• 8-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoateReach from here →
  1. triacylglycerol acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. arachidonate to 8-peroxy-(5Z,9E,11Z,14Z)-eicosatetraenoate conversion

  Catalysed by LPLextracellular space, cytosolOne of 2 routes

• 1,2,3-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerolReach from here →
  1. triacylglycerol acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. 1,2,3-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + H2O = 1,2-di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + H(+)

  Catalysed by LPL, DAGLBextracellular space

• N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-serineReach from here →
  1. triacylglycerol acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-serine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + L-serine

  Catalysed by LPL, FAAH, PM20D1extracellular space

• an N-(fatty acyl)-glycineReach from here →
  1. a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)
  2. a fatty acid + ATP + CoA = a fatty acyl-CoA + AMP + diphosphate
  3. a fatty acyl-CoA + glycine = an N-(fatty acyl)-glycine + CoA + H(+)

  Catalysed by DDHD2, LPL, LIPF, ABHD2 and 17 more

• (7Z)-octadecenoyl-CoAReach from here →
  1. triacylglycerol acylhydrolase
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. carnitine O-palmitoyltransferase ((7Z)-octadecenoyl-CoA)

  Catalysed by LPL, DGAT1, MOGAT2, MOGAT3 and 5 moreextracellular space, cytosolOne of 3 routes

• CHEBI:15345Reach from here →
  1. triacylglycerol acylhydrolase
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. Acetoacetate:CoA ligase (AMP-forming)

  Catalysed by LPL, DGAT1, MOGAT2, MOGAT3 and 3 moreextracellular space, cytosolOne of 2 routes

• cholineReach from here →
  1. triacylglycerol acylhydrolase
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. Acetyl-CoA:choline O-acetyltransferase

  Catalysed by LPL, DGAT1, MOGAT2, MOGAT3 and 3 moreextracellular space, cytosol, nucleusOne of 11 routes

• CHEBI:15380Reach from here →
  1. triacylglycerol acylhydrolase
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. 5-aminolevulinate synthase (2-amino-3-oxoadipate)

  Catalysed by LPL, DGAT1, MOGAT2, MOGAT3 and 4 moreextracellular space, cytosol, mitochondrial matrixOne of 8 routes

• CHEBI:15477Reach from here →
  1. triacylglycerol acylhydrolase
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. glycine N-acyltransferase (2-methylbutyryl-CoA)

  Catalysed by LPL, DGAT1, MOGAT2, MOGAT3 and 5 moreextracellular space, cytosol, mitochondrial matrixOne of 2 routes

• 2-methylcrotonoyl-CoAReach from here →
  1. triacylglycerol acylhydrolase
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. Production of Tiglylcarnitine

  Catalysed by LPL, DGAT1, MOGAT2, MOGAT3 and 4 moreextracellular space, cytosolOne of 2 routes

• isobutyryl-CoAReach from here →
  1. triacylglycerol acylhydrolase
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. acetyl-CoA C-acyltransferase (3-oxo-4-methyl-pentanoyl-CoA)

  Catalysed by LPL, DGAT1, MOGAT2, MOGAT3 and 5 moreextracellular space, cytosol, mitochondrial matrixOne of 3 routes

• 3-methylbut-2-enoyl-CoAReach from here →
  1. triacylglycerol acylhydrolase
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. glycine-N-acyltransferase (3-methylcrotonoylglycine)

  Catalysed by LPL, DGAT1, MOGAT2, MOGAT3 and 3 moreextracellular space, cytosol, mitochondrial matrix

• isovaleryl-CoAReach from here →
  1. triacylglycerol acylhydrolase
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. glycine N-acyltransferase (isovalerylglycine)

  Catalysed by LPL, DGAT1, MOGAT2, MOGAT3 and 5 moreextracellular space, cytosol, mitochondrial matrixOne of 3 routes

• arachidonoyl-CoAReach from here →
  1. triacylglycerol acylhydrolase
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. Arachidonate:CoA ligase (AMP-forming)

  Catalysed by LPL, DGAT1, MOGAT2, MOGAT3 and 10 moreextracellular space, cytosolOne of 14 routes

• CHEBI:15519Reach from here →
  1. triacylglycerol acylhydrolase
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. propanoyl-CoA C-acyltransferase

  Catalysed by LPL, DGAT1, MOGAT2, MOGAT3 and 5 moreextracellular space, cytosol, peroxisomeOne of 2 routes

• palmitoyl-CoAReach from here →
  1. triacylglycerol acylhydrolase
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. Palmitate:CoA ligase (AMP-forming)

  Catalysed by LPL, DGAT1, MOGAT2, MOGAT3 and 10 moreextracellular space, cytosolOne of 14 routes

• oleoyl-CoAReach from here →
  1. triacylglycerol acylhydrolase
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. Transport of octadecenoyl-CoA into Mitochondrial Matrix

  Catalysed by LPL, DGAT1, MOGAT2, MOGAT3 and 5 moreextracellular space, cytosolOne of 14 routes

• phenylacetyl-CoAReach from here →
  1. triacylglycerol acylhydrolase
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. Phenylacetate:CoA ligase

  Catalysed by LPL, DGAT1, MOGAT2, MOGAT3 and 2 moreextracellular space, cytosolOne of 3 routes

• propionyl-CoAReach from here →
  1. triacylglycerol acylhydrolase
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. Propanoate:CoA ligase (AMP-forming)

  Catalysed by LPL, DGAT1, MOGAT2, MOGAT3 and 5 moreextracellular space, cytosolOne of 43 routes

• (7S)-hydroperoxy-(4Z,8E,10Z,13Z,16Z,19Z)-docosahexaenoateReach from here →
  1. triacylglycerol acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 = (7S)-hydroperoxy-(4Z,8E,10Z,13Z,16Z,19Z)-docosahexaenoate

  Catalysed by LPL, ALOX5extracellular space

• (11S)-hydroperoxy-(4Z,7Z,9E,13Z,16Z,19Z)-docosahexaenoateReach from here →
  1. triacylglycerol acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 = (11S)-hydroperoxy-(4Z,7Z,9E,13Z,16Z,19Z)-docosahexaenoate

  Catalysed by LPL, ALOX15extracellular space

• 12(S)-HPETEReach from here →
  1. triacylglycerol acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. arachidonate:oxygen 12-oxidoreductase

  Catalysed by LPL, ALOX12extracellular space, cytosolOne of 4 routes

• 15(S)-HPETEReach from here →
  1. triacylglycerol acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. arachidonate:oxygen 15-oxidoreductase

  Catalysed by LPL, ALOX15B, ALOX15extracellular space, cytosolOne of 4 routes

• 5(S)-HPETEReach from here →
  1. triacylglycerol acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. Arachidonate:oxygen 5-oxidoreductase

  Catalysed by LPL, ALOX5extracellular space, cytosol

• a 1-hexadecanoyl-2-acylglycerolReach from here →
  1. triacylglycerol acylhydrolase
  2. a 1,2-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid + H(+)
  3. a 2-acylglycerol + hexadecanoyl-CoA = a 1-hexadecanoyl-2-acylglycerol + CoA

  Catalysed by LPL, DAGLB, ABHD11, DAGLA and 1 moreextracellular space

• an hexadecanoyl-acylglycerolReach from here →
  1. a triacylglycerol + H2O = a 1,2-diacylglycerol + a fatty acid + H(+)
  2. a 1,2-diacylglycerol + H2O = a 1-acylglycerol + a fatty acid + H(+)
  3. a 1-acylglycerol + hexadecanoyl-CoA = an hexadecanoyl-acylglycerol + CoA

  Catalysed by LIPA, PNPLA4, LIPN, PNPLA2 and 1 more

• CHEBI:15650Reach from here →
  1. triacylglycerol acylhydrolase
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. N-acetyl-LTE4 to leukotriene E4 conversion

  Catalysed by LPL, DGAT1, MOGAT2, MOGAT3 and 34 moreextracellular space, cytosolOne of 2 routes

• all-trans-3-hydroxyretinolReach from here →
  1. a triacylglycerol + all-trans-retinol = an all-trans-retinyl ester + a diacylglycerol
  2. carboxylesterase (retinyl-ester)
  3. all-trans-retinol + 2 reduced [adrenodoxin] + O2 + 2 H(+) = all-trans-3-hydroxyretinol + 2 oxidized [adrenodoxin] + H2O

  Catalysed by PNPLA4, PNPLA2, CES2, RBP4 and 17 morecytosol

• CHEBI:15727Reach from here →
  1. triacylglycerol acylhydrolase
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. N-alpha-acetyltransferase 10, NatA catalytic subunit (acetylcarnosine)

  Catalysed by LPL, DGAT1, MOGAT2, MOGAT3 and 3 moreextracellular space, cytosol

• CHEBI:15746Reach from here →
  1. triacylglycerol acylhydrolase
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. diamine N-acetyltransferase (N1-acetylspermine)

  Catalysed by LPL, DGAT1, MOGAT2, MOGAT3 and 4 moreextracellular space, cytosolOne of 2 routes

• a 1-O-alkyl-sn-glycerolReach from here →
  1. a triacylglycerol + H2O = a 1,2-diacylglycerol + a fatty acid + H(+)
  2. a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + a 1,2-diacylglycerol = a 1-O-alkyl-sn-glycero-3-phosphocholine + a triacylglycerol
  3. a 1-O-alkyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycerol + phosphocholine + H(+)

  Catalysed by LIPA, PNPLA4, LIPN, PNPLA2 and 2 more

• a sterolReach from here →
  1. a triacylglycerol + H2O = a 1,2-diacylglycerol + a fatty acid + H(+)
  2. a 1,2-diacylglycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = a triacylglycerol + a 1-acyl-sn-glycero-3-phosphocholine
  3. a sterol + a 1,2-diacyl-sn-glycero-3-phosphocholine = a sterol ester + a 1-acyl-sn-glycero-3-phosphocholine

  Catalysed by LIPA, PNPLA4, LIPN, PNPLA2 and 2 more

• 11-cis-retinalReach from here →
  1. a triacylglycerol + all-trans-retinol = an all-trans-retinyl ester + a diacylglycerol
  2. all-trans-retinyl ester acylhydrolase, 11-cis-retinol forming
  3. 11-cis-retinol:NAD+ oxidoreductase

  Catalysed by PNPLA4, PNPLA2, RPE65, HSD17B6 and 6 morecytosolOne of 4 routes

• cholesterolReach from here →
  1. triacylglycerol acylhydrolase
  2. an N-acylsphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol
  3. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + an N-acylsphing-4-enine

  Catalysed by LPL, SGMS1, SGMS2, GBA1 and 1 moreextracellular spaceOne of 3 routes

• 11-cis-retinyl hexadecanoateReach from here →
  1. triacylglycerol acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. 11-peroxy-docosahexaenoate to DHA conversion

  Catalysed by LPLextracellular space, cytosolOne of 5 routes

• oxaloacetateReach from here →
  1. triacylglycerol acylhydrolase
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. ATP citrate lyase (citrate)

  Catalysed by LPL, DGAT1, MOGAT2, MOGAT3 and 3 moreextracellular space, cytosol

• CHEBI:16566Reach from here →
  1. triacylglycerol acylhydrolase
  2. an N-acylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = an N-acylsphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
  3. N-acylsphingosine amidohydrolase

  Catalysed by LPL, SGMS1, SGMS2, ASAH1 and 4 moreextracellular space, cytosol

• 8-hydroxydodecanoateReach from here →
  1. triacylglycerol acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. dodecanoate + reduced [NADPH--hemoprotein reductase] + O2 = 8-hydroxydodecanoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by LPL, CYP4Z1extracellular space