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Proteins/UNIPROT:O95427
Ethanolamine phosphate transferase that catalyzes an ethanolamine phosphate (EtNP) transfer from phosphatidylethanolamine (PE) to the 2-OH position of the first alpha-1,4-linked mannose of a 2-acyl-6-[alpha-D-mannosyl-(1->6)-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol (also termed H3) intermediate to generate a 2-acyl-6-[alpha-D-mannosyl-(1->6)-2-phosphoethanolamine-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol and participates in the eighth step of the glycosylphosphatidylinositol-anchor biosynthesis (By similarity). Also transfers the EtNP on a mannosyl GPI intermediate, 2-acyl-6-(alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl)-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol (also termed H2) (By similarity). May act as suppressor of replication stress and chromosome missegregation..
Function from UniProtKB (O95427), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
2 rows
24 statements
24 statements · 6 reference databases · Subject: PIGN · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
7 reactions
MAM02483r+phosphatidylethanolaminea 1,2-diacyl-sn-glycerol+MAM01783r
Catalysed by PIGN
Reaction pageLeft to rightBalance undeterminableEC 2.7.-.-endoplasmic reticulum
Human-GEM MAR08391CC BY 4.0Reference data
MAM02431r+phosphatidylethanolaminea 1,2-diacyl-sn-glycerol+MAM02463r
Catalysed by PIGN
Reaction pageLeft to rightBalance undeterminableEC 2.7.-.-endoplasmic reticulum
6 names
Resolves to: PIGN
MAM02433r+phosphatidylethanolaminea 1,2-diacyl-sn-glycerol+MAM02430r
Catalysed by PIGN
Reaction pageLeft to rightBalance undeterminableEC 2.7.-.-endoplasmic reticulum
Human-GEM MAR08394CC BY 4.0Reference data
MAM01781r+phosphatidylethanolaminea 1,2-diacyl-sn-glycerol+MAM01779r
Catalysed by PIGN
Reaction pageLeft to rightBalance undeterminableEC 2.7.-.-endoplasmic reticulum
Human-GEM MAR08397CC BY 4.0Reference data
MAM01782r+phosphatidylethanolaminea 1,2-diacyl-sn-glycerol+MAM02020r
Catalysed by PIGN
Reaction pageLeft to rightBalance undeterminableEC 2.7.-.-endoplasmic reticulum
Human-GEM MAR08399CC BY 4.0Reference data
a 2-acyl-6-(alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl)-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol+a 1,2-diacyl-sn-glycero-3-phosphoethanolaminea 2-acyl-6-[2-phosphoethanolamine-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol+a 1,2-diacyl-sn-glycerol
Catalysed by PIGN
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:60896CC BY 4.0Reference data
a 2-acyl-6-[alpha-D-mannosyl-(1->6)-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol+a 1,2-diacyl-sn-glycero-3-phosphoethanolaminea 2-acyl-6-[alpha-D-mannosyl-(1->6)-2-phosphoethanolamine-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol+a 1,2-diacyl-sn-glycerol
Catalysed by PIGN
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:83767CC BY 4.0Reference data