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Proteins/UNIPROT:Q8NFV4
Catalyzes the hydrolysis of diacylglycerol in vitro and may function as a key regulator in lipid metabolism, namely by regulating the intracellular levels of diacylglycerol. 1,2-diacyl-sn-glycerols are the preferred substrate over 1,3-diacyl-sn-glycerols (By similarity). The enzyme hydrolyzes stearate in preference to palmitate from the sn-1 position of 1,2-diacyl-sn-glycerols (By similarity). Maintains the functional lipoylation of the 2-oxoglutarate dehydrogenase complex (OGDHc) through its interaction with the OGDHc by preventing the formation of lipoyl adducts. In addition, is also required for the expansion and differentiation of embryonic stem cells (ESCs) (By similarity)..
Function from UniProtKB (Q8NFV4), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
31 statements
31 statements · 4 reference databases · Subject: ABHD11 · Sources: Bgee, Hetionet, Rhea, WikiPathways
6 reactions
a 1,2-diacyl-sn-glycerol+watera 2-acylglycerol+a fatty acid+hydron
Catalysed by DAGLB or ABHD11 or DAGLA
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:33275CC BY 4.0Reference data
a 1,3-diacyl-sn-glycerol+watera 1-acyl-sn-glycerol+a fatty acid+hydron
4 names
Resolves to: ABHD11
Catalysed by ABHD11
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:38503CC BY 4.0Reference data
1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol+water2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol+octadecanoate+hydron
Catalysed by DAGLB or ABHD11 or DAGLA
Reaction pageLeft to rightBalanced
Rhea RHEA:38507CC BY 4.0Reference data
CHEBI:11152+waterCHEBI:90605+decanoate+hydron
Catalysed by PNLIPRP2 or ABHD11
Reaction pageLeft to rightBalanced
Rhea RHEA:48596CC BY 4.0Reference data
1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol+water2-(9Z-octadecenoyl)-glycerol+octadecanoate+hydron
Catalysed by ABHD11
Reaction pageDirection not assertedBalanced
Rhea RHEA:77103CC BY 4.0Reference data
1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol+water2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol+octadecanoate+hydron
Catalysed by ABHD11
Reaction pageDirection not assertedBalanced
Rhea RHEA:77107CC BY 4.0Reference data