What it touches on the way
Mechanistic reach
2 entities
2 entities reached.
0 reported hops2 assembled from the scaffold
What the reference databases state
Statements
7 statements
7 statements · 1 reference database · Subject: cortisone · Sources: Human-GEM
- cortisone is converted to cortisolCompoundHuman-GEM MAR07943Inferred only
- cortisone is converted to cortisolCompoundHuman-GEM MAR07942Inferred only
- cortisol is converted to cortisoneCompoundHuman-GEM MAR01996Inferred only
- cortisol is converted to cortisoneCompoundHuman-GEM MAR07942Inferred only
- cortisol is converted to cortisoneCompoundHuman-GEM MAR07943Inferred only
- cortisone is a substrate of HSD11B1ProteinHuman-GEM MAR07942Inferred only
- cortisone is a substrate of HSD11B2ProteinHuman-GEM MAR07943Inferred only
Reactions
12 reactions
cortisol+NADP(3-)cortisone+proton+NADPH(4-)
Catalysed by HSD11B1
Reaction pageLeft to rightBalancedEC 1.1.1.146GO:0005829
Human-GEM MAR01996CC BY 4.0Reference data
cortisone+proton+NADPH(4-)cortisol+NADP(3-)
Catalysed by HSD11B1
Reaction pageReversibleBalancedEC 1.1.1.146GO:0005783
Human-GEM MAR07942CC BY 4.0Reference data
cortisone+proton+NADH(2-)cortisol+NAD(+)
Catalysed by HSD11B2
Reaction pageReversibleBalancedEC 1.1.1.-GO:0005783
Human-GEM MAR07943CC BY 4.0Reference data
Reaction pageReversibleBalancedGO:0005829, GO:0005615
Human-GEM MAR10174CC BY 4.0Reference data
Reaction pageReversibleBalancedGO:0005783, GO:0005829
Human-GEM MAR10175CC BY 4.0Reference data
Reaction pageReversibleBalance undeterminableGO:0005615
Human-GEM MAR10235CC BY 4.0Reference data
CHEBI:18093+NADP(3-)cortisone+NADPH(4-)+hydron
Catalysed by AKR1D1
Reaction pageRight to leftBalance undeterminable
Rhea RHEA:14037CC BY 4.0Reference data
cortisone+NAD(1-)CHEBI:78596+NADH(2-)+hydron
Catalysed by HSD17B10
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:42016CC BY 4.0Reference data
cortisol+NAD(1-)cortisone+NADH(2-)+hydron
Catalysed by HSD11B2
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:50208CC BY 4.0Reference data
cortisone+reduced [NADPH--hemoprotein reductase]+dioxygenCHEBI:139269+oxidized [NADPH--hemoprotein reductase]+water+hydron
Catalysed by CYP3A4
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:55832CC BY 4.0Reference data
cortisone+NADPH(4-)+hydroncortisol+NADP(3-)
Catalysed by HSD11B1 or HSD11B1L
Reaction pageReversibleBalance undeterminable
Rhea RHEA:68616CC BY 4.0Reference data
cortisone+NADPH(4-)+hydronCHEBI:178084+NADP(3-)
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:68620CC BY 4.0Reference data