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cholesteryl 3-beta-D-glucoside

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

Inferred

Every route here is a hypothesis drawn from reference reactions (Rhea and Human-GEM), not a finding. Currency species such as water, ATP and NAD(H) never form a step. Evidence key

186 compounds within 3 steps: 9 in 1, 52 in 2, 125 in 3

Does it reach a compound?

Two steps

cholesteryl octadecanoateReach from here →
1. cholesteryl 3-beta-D-glucoside + H2O = cholesterol + D-glucose
2. octadecanoyl-CoA + cholesterol = cholesteryl octadecanoate + CoA
Catalysed by GBA1, GBA2, SOAT1
cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
1. cholesteryl 3-beta-D-glucoside + H2O = cholesterol + D-glucose
2. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA
Catalysed by GBA1, GBA2, SOAT2, SOAT1One of 2 routes
beta-D-glucosyl-(1<->1)-sphing-4-enineReach from here →
1. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + an N-acylsphing-4-enine
2. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = beta-D-glucosyl-(1<->1)-sphing-4-enine + a fatty acid
Catalysed by GBA1, GBA2, ASAH1
cholesteryl (9Z)-hexadecenoateReach from here →
1. cholesteryl 3-beta-D-glucoside + H2O = cholesterol + D-glucose
2. (9Z)-hexadecenoyl-CoA + cholesterol = cholesteryl (9Z)-hexadecenoate + CoA
Catalysed by GBA1, GBA2, SOAT1
(9Z,12Z,15Z-octadecatrienoyl)-cholesterolReach from here →
1. cholesteryl 3-beta-D-glucoside + H2O = cholesterol + D-glucose
2. (9Z,12Z,15Z)-octadecatrienoyl-CoA + cholesterol = (9Z,12Z,15Z-octadecatrienoyl)-cholesterol + CoA
Catalysed by GBA1, GBA2, SOAT2One of 2 routes
cholesteryl (8Z,11Z,14Z)-eicosatrienoateReach from here →
1. cholesteryl 3-beta-D-glucoside + H2O = cholesterol + D-glucose
2. 1-hexadecanoyl-2-(8Z,11Z,14Z-eicosatrienoyl)-sn-glycero-3-phosphocholine + cholesterol = cholesteryl (8Z,11Z,14Z)-eicosatrienoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine
Catalysed by GBA1, GBA2, LCAT
(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-cholesterolReach from here →
1. cholesteryl 3-beta-D-glucoside + H2O = cholesterol + D-glucose
2. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + cholesterol = (5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-cholesterol + CoA
Catalysed by GBA1, GBA2, SOAT2One of 2 routes
4beta-hydroxycholesterolReach from here →
1. cholesteryl 3-beta-D-glucoside + H2O = cholesterol + D-glucose
2. cholesterol + reduced [NADPH--hemoprotein reductase] + O2 = 4beta-hydroxycholesterol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Catalysed by GBA1, GBA2, CYP3A4
cholesteryl (5Z,8Z,11Z)-eicosatrienoateReach from here →
1. cholesteryl 3-beta-D-glucoside + H2O = cholesterol + D-glucose
2. 1-hexadecanoyl-2-(5Z,8Z,11Z-eicosatrienoyl)-sn-glycero-3-phosphocholine + cholesterol = cholesteryl (5Z,8Z,11Z)-eicosatrienoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine
Catalysed by GBA1, GBA2, LCAT
(6Z,9Z,12Z-octadecatrienoyl)-cholesterolReach from here →
1. cholesteryl 3-beta-D-glucoside + H2O = cholesterol + D-glucose
2. 1-hexadecanoyl-2-(6Z,9Z,12Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + cholesterol = (6Z,9Z,12Z-octadecatrienoyl)-cholesterol + 1-hexadecanoyl-sn-glycero-3-phosphocholine
Catalysed by GBA1, GBA2, LCAT
cholesteryl (11Z)-octadecenoateReach from here →
1. cholesteryl 3-beta-D-glucoside + H2O = cholesterol + D-glucose
2. (11Z)-octadecenoyl-CoA + cholesterol = cholesteryl (11Z)-octadecenoate + CoA
Catalysed by GBA1, GBA2, SOAT1

Three steps

(20R,22R)-20,22-dihydroxycholesterolReach from here →
Catalysed by GBA1, GBA2, CYP11A1
CHEBI:12947Reach from here →

Page 2 of 4

Catalysed by GBA1, GBA2, UGT8

cytosol

One of 5 routes

CHEBI:1307929Reach from here →

cholesteryl 3-beta-D-glucoside + H2O = cholesterol + D-glucose
cholesterol + (9Z)-octadecenoyl-CoA = cholesteryl (9Z-octadecenoate) + CoA
Steryl-ester acylhydrolase

Catalysed by GBA1, GBA2, SOAT2, SOAT1 and 2 morelysosomeOne of 18 routes

pregnenolone sulfateReach from here →

cholesteryl 3-beta-D-glucoside + H2O = cholesterol + D-glucose
6 reduced [adrenodoxin] + cholesterol + 3 O2 + 6 H(+) = 4-methylpentanal + pregnenolone + 6 oxidized [adrenodoxin] + 4 H2O
3'-phosphoadenylyl-sulfate:pregnenolone sulfotransferase

Catalysed by GBA1, GBA2, CYP11A1, SULT2B1cytosolOne of 4 routes

(24S)-hydroxycholesterol 24-sulfateReach from here →

cholesteryl 3-beta-D-glucoside + H2O = cholesterol + D-glucose
cholesterol + reduced [NADPH--hemoprotein reductase] + O2 = (24S)-hydroxycholesterol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
(24S)-hydroxycholesterol + 3'-phosphoadenylyl sulfate = (24S)-hydroxycholesterol 24-sulfate + adenosine 3',5'-bisphosphate + H(+)

Catalysed by GBA1, GBA2, CYP46A1, SULT2A1

(24S)-hydroxycholesterol 3-sulfateReach from here →

cholesteryl 3-beta-D-glucoside + H2O = cholesterol + D-glucose
cholesterol + reduced [NADPH--hemoprotein reductase] + O2 = (24S)-hydroxycholesterol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
(24S)-hydroxycholesterol + 3'-phosphoadenylyl sulfate = (24S)-hydroxycholesterol 3-sulfate + adenosine 3',5'-bisphosphate + H(+)

Catalysed by GBA1, GBA2, CYP46A1, SULT2B1 and 2 more

a 3-(acyloxy)acyl derivative of bacterial toxinReach from here →

a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + an N-acylsphing-4-enine
a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = beta-D-glucosyl-(1<->1)-sphing-4-enine + a fatty acid
a 3-(acyloxy)acyl derivative of bacterial toxin + H2O = a 3-hydroxyacyl derivative of bacterial toxin + a fatty acid + H(+)

Catalysed by GBA1, GBA2, ASAH1, AOAH

an N-acyl-sphinga-4E,14Z-dienineReach from here →

cholesteryl 3-beta-D-glucoside + H2O = cholesterol + D-glucose
a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + an N-acylsphing-4-enine
an N-acylsphing-4-enine + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = an N-acyl-sphinga-4E,14Z-dienine + 2 Fe(III)-[cytochrome b5] + 2 H2O

Catalysed by GBA1, GBA2, FADS3

sn-glycero-3-phosphoethanolamineReach from here →

cholesteryl 3-beta-D-glucoside + H2O = cholesterol + D-glucose
1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine
1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-sn-glycero-3-phosphocholine = sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine

Catalysed by GBA1, GBA2, LCAT, PLA2G4C

cholineReach from here →

cholesteryl 3-beta-D-glucoside + H2O = cholesterol + D-glucose
1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine
1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphate + choline + H(+)

Catalysed by GBA1, GBA2, LCAT, ENPP2 and 2 more

pyruvateReach from here →

cholesteryl 3-beta-D-glucoside + H2O = cholesterol + D-glucose
dATP:D-glucose 6-phosphotransferase
dATP:pyruvate 2-O-phosphotransferase

Catalysed by GBA1, GBA2, HK1, HK2 and 4 morecytosol

betaine aldehydeReach from here →

cholesteryl 3-beta-D-glucoside + H2O = cholesterol + D-glucose
cholesterol + AH2 + O2 = 25-hydroxycholesterol + A + H2O
choline + A = betaine aldehyde + AH2

Catalysed by GBA1, GBA2, CH25H, CHDH

hexadecanoic acidReach from here →

cholesteryl 3-beta-D-glucoside + H2O = cholesterol + D-glucose
cholesterol + hexadecanoyl-CoA = cholesteryl hexadecanoate + CoA
Steryl-ester acylhydrolase

Catalysed by GBA1, GBA2, SOAT1, CEL and 1 morelysosomeOne of 3 routes

keto-D-fructose 6-phosphateReach from here →

cholesteryl 3-beta-D-glucoside + H2O = cholesterol + D-glucose
ATP:D-glucose 6-phosphotransferase
D-glucose-6-phosphate aldose-ketose-isomerase

Catalysed by GBA1, GBA2, HK1, GCK and 4 morecytosol

thioredoxin dithiolReach from here →

cholesteryl 3-beta-D-glucoside + H2O = cholesterol + D-glucose
dATP:D-glucose 6-phosphotransferase
2-Deoxyuridine 5-Diphosphate:Oxidized-Thioredoxin 2-Oxidoreductase

Catalysed by GBA1, GBA2, HK1, HK2 and 7 morecytosol, mitochondrial matrixOne of 2 routes

CHEBI:16039Reach from here →

cholesteryl 3-beta-D-glucoside + H2O = cholesterol + D-glucose
ITP:D-glucose 6-phosphotransferase
ATP:IDP phosphotransferase

Catalysed by GBA1, GBA2, HK1, HK2 and 7 morecytosolOne of 3 routes

sulfateReach from here →

cholesteryl 3-beta-D-glucoside + H2O = cholesterol + D-glucose
cholesterol + 3'-phosphoadenylyl sulfate = cholesterol sulfate + adenosine 3',5'-bisphosphate + H(+)
Cholesterol-sulfate sulfohydrolase

Catalysed by GBA1, GBA2, SULT2B1, SULT1C2 and 1 morecytosolOne of 4 routes

CHEBI:16284Reach from here →

cholesteryl 3-beta-D-glucoside + H2O = cholesterol + D-glucose
dATP:D-glucose 6-phosphotransferase
ATP:dADP phosphotransferase

Catalysed by GBA1, GBA2, HK1, HK2 and 7 morecytosolOne of 16 routes

oxaloacetateReach from here →

cholesteryl 3-beta-D-glucoside + H2O = cholesterol + D-glucose
cholesterol + AH2 + O2 = 25-hydroxycholesterol + A + H2O
(R)-malate + A = oxaloacetate + AH2

Catalysed by GBA1, GBA2, CH25H, D2HGDH

alpha,alpha-trehaloseReach from here →

cholesteryl 3-beta-D-glucoside + H2O = cholesterol + D-glucose
D-glucose 1-epimerase
alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-glucose

Catalysed by GBA1, GBA2, GALM, TREHcytosol

1-phosphatidyl-1D-myo-inositolReach from here →

cholesteryl 3-beta-D-glucoside + H2O = cholesterol + D-glucose
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(out) + cholesterol(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(in) + cholesterol(out)
ATP:1-Phosphatidyl-1D-myo-inositol 4-phosphotransferase

Catalysed by GBA1, GBA2, OSBP, PTPRQ and 12 moreinner side of the membrane, outer side of the membrane, cytosolOne of 2 routes

formaldehydeReach from here →

cholesteryl 3-beta-D-glucoside + H2O = cholesterol + D-glucose
cholesterol + AH2 + O2 = 25-hydroxycholesterol + A + H2O
N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + 2 A + 2 H2O = L-lysyl(4)-[histone H3] + 2 formaldehyde + 2 AH2

Catalysed by GBA1, GBA2, CH25H, KDM1A and 1 moreOne of 3 routes

sn-glycerol 3-phosphocholineReach from here →

cholesteryl 3-beta-D-glucoside + H2O = cholesterol + D-glucose
1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine
1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + hexadecanoate + H(+)

Catalysed by GBA1, GBA2, LCAT, PLA2G6 and 16 moreOne of 6 routes

progesteroneReach from here →

cholesteryl 3-beta-D-glucoside + H2O = cholesterol + D-glucose
6 reduced [adrenodoxin] + cholesterol + 3 O2 + 6 H(+) = 4-methylpentanal + pregnenolone + 6 oxidized [adrenodoxin] + 4 H2O
Pregnenolone:NAD+ 3-oxidoreductase

Catalysed by GBA1, GBA2, CYP11A1, HSD3B1 and 1 morecytosolOne of 2 routes

a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E))Reach from here →

a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + an N-acylsphing-4-enine
a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + UDP-alpha-D-galactose = a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP + H(+)
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase (LacCer pool)

Catalysed by GBA1, GBA2, B4GALT5, B4GALT6 and 1 morecytosolOne of 3 routes

CHEBI:17202Reach from here →

cholesteryl 3-beta-D-glucoside + H2O = cholesterol + D-glucose
ITP:D-glucose 6-phosphotransferase
IDP phosphohydrolase

Catalysed by GBA1, GBA2, HK1, HK2 and 10 morecytosol, extracellular space

all-trans-retinolReach from here →

cholesteryl 3-beta-D-glucoside + H2O = cholesterol + D-glucose
cholesterol + AH2 + O2 = 25-hydroxycholesterol + A + H2O
all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2

Catalysed by GBA1, GBA2, CH25H, RETSAT

linoleic acidReach from here →

cholesteryl 3-beta-D-glucoside + H2O = cholesterol + D-glucose
(9Z,12Z)-octadecadienoyl-CoA + cholesterol = cholesteryl (9Z,12Z)-octadecadienoate + CoA
Steryl-ester acylhydrolase

Catalysed by GBA1, GBA2, SOAT1, CEL and 1 morelysosomeOne of 2 routes

a monoacylglycerolReach from here →

a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + an N-acylsphing-4-enine
a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = beta-D-glucosyl-(1<->1)-sphing-4-enine + a fatty acid
a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)

Catalysed by GBA1, GBA2, ASAH1, LIPE

AH2Reach from here →

cholesteryl 3-beta-D-glucoside + H2O = cholesterol + D-glucose
cholesterol + AH2 + O2 = 25-hydroxycholesterol + A + H2O
A + NADH + H(+) = AH2 + NAD(+)

Catalysed by GBA1, GBA2, CH25H, AIFM1 and 1 moreOne of 19 routes

L-cysteineReach from here →

cholesteryl 3-beta-D-glucoside + H2O = cholesterol + D-glucose
cholesterol + AH2 + O2 = 25-hydroxycholesterol + A + H2O
Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

Catalysed by GBA1, GBA2, CH25H, MOCOS

a sphingomyelinReach from here →

cholesteryl 3-beta-D-glucoside + H2O = cholesterol + D-glucose
a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + an N-acylsphing-4-enine
ceramide:phosphatidylcholine cholinephosphotransferase

Catalysed by GBA1, GBA2, SGMS1, SGMS2Golgi apparatusOne of 8 routes

a 1,2-diacyl-sn-glycerolReach from here →

cholesteryl 3-beta-D-glucoside + H2O = cholesterol + D-glucose
a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + an N-acylsphing-4-enine
ceramide:phosphatidylcholine cholinephosphotransferase

Catalysed by GBA1, GBA2, SGMS1, SGMS2Golgi apparatusOne of 9 routes

7alpha-hydroxycholest-4-en-3-oneReach from here →

cholesteryl 3-beta-D-glucoside + H2O = cholesterol + D-glucose
cholesterol + AH2 + O2 = 25-hydroxycholesterol + A + H2O
Cholest-5-Ene-3Beta, 7Alpha-Diol:NAD+ 3-Oxidoreductase Bile Acid Biosynthesis

Catalysed by GBA1, GBA2, CH25H, HSD3B7endoplasmic reticulumOne of 5 routes

alpha-D-glucoseReach from here →

cholesteryl 3-beta-D-glucoside + H2O = cholesterol + D-glucose
D-glucose 1-epimerase
alpha-D-glucose = beta-D-glucose

Catalysed by GBA1, GBA2, GALMcytosol

dTDPReach from here →

cholesteryl 3-beta-D-glucoside + H2O = cholesterol + D-glucose
dATP:D-glucose 6-phosphotransferase
nucleoside-diphosphate kinase (dADP)

Catalysed by GBA1, GBA2, HK1, HK2 and 8 morecytosolOne of 3 routes

dodecanoateReach from here →

cholesteryl 3-beta-D-glucoside + H2O = cholesterol + D-glucose
1-(beta-D-galactosyl)-N-dodecanoylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-galactoside + N-dodecanoylsphing-4-enine
H2O[c] + N-dodecanoylsphing-4-enine[c] = lauric acid[c] + sphingosine[c]

Catalysed by GBA1, GBA2, NAAAcytosolOne of 2 routes

a globoside Gb3Cer (d18:1(4E))Reach from here →

a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + an N-acylsphing-4-enine
a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + UDP-alpha-D-galactose = a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP + H(+)
alpha 1,4-galactosyltransferase (P blood group) (LacCer pool)

Catalysed by GBA1, GBA2, B4GALT5, B4GALT6 and 1 morecytosolOne of 3 routes

D-glucosyl-N-acylsphingosineReach from here →

cholesteryl 3-beta-D-glucoside + H2O = cholesterol + D-glucose
a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + an N-acylsphing-4-enine
UDP-glucose:N-acylsphingosine D-glucosyltransferase

Catalysed by GBA1, GBA2, UGCGcytosolOne of 3 routes