iodide

Three steps

• N(omega)-methyl-L-arginineReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. N(omega)-methyl-L-arginine + glyoxylate = 5-(3-methylguanidino)-2-oxopentanoate + glycine

  Catalysed by SLC26A4, SLC6A9, SLC6A14, AGXT2extracellular space, cytosolOne of 4 routes

• 3-methyl-2-oxobutanoateReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of chloride and valine (cytosol to extracellular)
  3. L-Valine:2-oxoglutarate aminotransferase

  Catalysed by SLC26A4, SLC6A14, BCAT2extracellular space, cytosol, mitochondrial matrixOne of 3 routes

• (5E)-tetradecenoyl-(R)-carnitineReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. Carnitine Transport by Atb0
  3. carnitine O-palmitoyltransferase ((9E)-tetradecenoyl-CoA)

  Catalysed by SLC26A4, SLC6A14, CPT1A, CPT1C and 1 moreextracellular space, cytosolOne of 7 routes

• tauroursodeoxycholateReach from here →
  1. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)
  2. transport of GSH and triiodothyronine (cytosol to extracellular)
  3. transport of GSH and tauroursodeoxycholate (cytosol to extracellular)

  Catalysed by DIO1, DIO3, DIO2, SLCO1A2 and 1 morecytosol, extracellular spaceOne of 6 routes

• glycoursodeoxycholateReach from here →
  1. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)
  2. transport of GSH and triiodothyronine (cytosol to extracellular)
  3. transport of glycoursodeoxycholate and GSH (cytosol to extracellular)

  Catalysed by DIO1, DIO3, DIO2, SLCO1A2 and 1 morecytosol, extracellular spaceOne of 6 routes

• (11S,15S)-dihydroxy-14(R)-S-glutathionyl-(5Z,8Z,12E)-eicosatrienoateReach from here →
  1. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)
  2. transport of GSH and triiodothyronine (cytosol to extracellular)
  3. glutathione transferase (GSH)

  Catalysed by DIO1, DIO3, DIO2, SLCO1A2 and 22 morecytosol, extracellular spaceOne of 4 routes

• pregnenolone sulfateReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Steryl-Sulfatase

  Catalysed by SLC26A4, SLC26A6, STSextracellular space, cytosol, Golgi apparatusOne of 2 routes

• androsterone 3alpha-sulfateReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. steroid sulfatase (androsterone sulfate)

  Catalysed by SLC26A4, SLC26A6, STSextracellular space, cytosolOne of 3 routes

• prostaglandin E3Reach from here →
  1. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)
  2. transport of GSH and triiodothyronine (cytosol to extracellular)
  3. transport of GSH and prostaglandin E3 (cytosol to extracellular)

  Catalysed by DIO1, DIO3, DIO2, SLCO1A2 and 2 morecytosol, extracellular spaceOne of 4 routes

• prostaglandin A2Reach from here →
  1. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)
  2. transport of GSH and triiodothyronine (cytosol to extracellular)
  3. transport of GSH and prostaglandin A2 (cytosol to extracellular)

  Catalysed by DIO1, DIO3, DIO2, SLCO1A2 and 2 morecytosol, extracellular spaceOne of 4 routes

• prostaglandin B1Reach from here →
  1. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)
  2. transport of GSH and triiodothyronine (cytosol to extracellular)
  3. transport of GSH and prostaglandin B1 (cytosol to extracellular)

  Catalysed by DIO1, DIO3, DIO2, SLCO1A2 and 2 morecytosol, extracellular spaceOne of 4 routes

• leukotriene F4Reach from here →
  1. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)
  2. transport of GSH and triiodothyronine (cytosol to extracellular)
  3. transport of GSH and leukotriene F4 (cytosol to extracellular)

  Catalysed by DIO1, DIO3, DIO2, SLCO1A2 and 1 morecytosol, extracellular spaceOne of 4 routes

• N-(9Z-octadecenoyl)glycineReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. (9Z)-octadecenoyl-CoA + glycine = N-(9Z-octadecenoyl)glycine + CoA + H(+)

  Catalysed by SLC26A4, SLC6A9, SLC6A14, GLYATL3 and 1 moreextracellular space, cytosol

• N-(9Z-octadecenoyl)-L-phenylalanineReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. Transport of L-Phenylalanine by Atb0 Transporter
  3. L-phenylalanine + (9Z)-octadecenoate = N-(9Z-octadecenoyl)-L-phenylalanine + H2O

  Catalysed by SLC26A4, SLC6A14, PM20D1extracellular space, cytosol

• N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanineReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. Transport of L-Phenylalanine by Atb0 Transporter
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + L-phenylalanine = N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanine + H2O

  Catalysed by SLC26A4, SLC6A14, PM20D1extracellular space, cytosol

• N-(9Z-octadecenoyl)-L-leucineReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of chloride and leucine (cytosol to extracellular)
  3. N-(9Z-octadecenoyl)-L-leucine + H2O = L-leucine + (9Z)-octadecenoate

  Catalysed by SLC26A4, SLC6A14, PM20D1extracellular space, cytosol

• N-octadecanoylglycineReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. octadecanoyl-CoA + glycine = N-octadecanoylglycine + CoA + H(+)

  Catalysed by SLC26A4, SLC6A9, SLC6A14, GLYATL2extracellular space, cytosol

• N-(9Z-hexadecenoyl)-glycineReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. (9Z)-hexadecenoyl-CoA + glycine = N-(9Z-hexadecenoyl)-glycine + CoA + H(+)

  Catalysed by SLC26A4, SLC6A9, SLC6A14, GLYATL2extracellular space, cytosol

• cholesterol sulfateReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Steryl-Sulfatase

  Catalysed by SLC26A4, SLC26A6, STSextracellular space, cytosol, Golgi apparatusOne of 2 routes

• 5alpha-dihydrotestosterone sulfateReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. steroid sulfatase (5-alpha-dihydrotestosterone)

  Catalysed by SLC26A4, SLC26A6, STSextracellular space, cytosolOne of 3 routes

• acetoacetateReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of chloride and formate (cytosol to extracellular)
  3. transport of acetoacetate and formate (cytosol to extracellular)

  Catalysed by SLC26A4, SLC16A4, SLC16A5extracellular space, cytosolOne of 2 routes

• an aryl sulfateReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. an aryl sulfate + H2O = a phenol + sulfate + H(+)

  Catalysed by SLC26A4, SLC26A6, ARSL, ARSF and 4 moreextracellular space, cytosol

• N-hexadecanoylglycineReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. hexadecanoyl-CoA + glycine = N-hexadecanoylglycine + CoA + H(+)

  Catalysed by SLC26A4, SLC6A9, SLC6A14, GLYATL3extracellular space, cytosol

• N-dodecanoylglycineReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)

  Catalysed by SLC26A4, SLC6A9, SLC6A14, GLYATL2extracellular space, cytosol

• N-decanoylglycineReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. decanoyl-CoA + glycine = N-decanoylglycine + CoA + H(+)

  Catalysed by SLC26A4, SLC6A9, SLC6A14, GLYATL2extracellular space, cytosol

• N-octanoylglycineReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. octanoyl-CoA + glycine = N-octanoylglycine + CoA + H(+)

  Catalysed by SLC26A4, SLC6A9, SLC6A14, GLYATL2extracellular space, cytosol

• L-homoarginineReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of arginine and chloride (cytosol to extracellular)
  3. L-homoarginine(in) + L-arginine(out) = L-homoarginine(out) + L-arginine(in)

  Catalysed by SLC26A4, SLC6A14, SLC25A29extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• L-homocarnosineReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of chloride and histidine (cytosol to extracellular)
  3. Formation of homocarnosine

  Catalysed by SLC26A4, SLC6A14, CARNS1extracellular space, cytosolOne of 3 routes

• N(1)-(5-phospho-beta-D-ribosyl)glycinamideReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. 5-phospho-beta-D-ribosylamine + glycine + ATP = N(1)-(5-phospho-beta-D-ribosyl)glycinamide + ADP + phosphate + H(+)

  Catalysed by SLC26A4, SLC6A9, SLC6A14, GARTextracellular space, cytosol

• L-cystine-bis-glycineReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. L-cystine-bis-glycine + 2 H2O = L-cystine + 2 glycine

  Catalysed by SLC26A4, SLC6A9, SLC6A14, DPEP1 and 1 moreextracellular space, cytosol

• glycyldehydrophenylalanineReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. glycyldehydrophenylalanine + H2O = 2,3-didehydrophenylalanine + glycine

  Catalysed by SLC26A4, SLC6A9, SLC6A14, DPEP1extracellular space, cytosol

• 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidineReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. Transport of L-Glutamine by Atb0 Transporter
  3. N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + L-glutamine + ATP + H2O = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + L-glutamate + ADP + phosphate + H(+)

  Catalysed by SLC26A4, SLC6A14, PFASextracellular space, cytosol

• kinetensinReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. Transport of L-Phenylalanine by Atb0 Transporter
  3. Chymase

  Catalysed by SLC26A4, SLC6A14, CMA1extracellular space, cytosolOne of 3 routes

• an N-(fatty acyl)-glycineReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. a fatty acyl-CoA + glycine = an N-(fatty acyl)-glycine + CoA + H(+)

  Catalysed by SLC26A4, SLC6A9, SLC6A14, GLYATL2extracellular space, cytosol

• N-(9Z,12Z-octadecadienoyl)-glycineReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. (9Z,12Z)-octadecadienoyl-CoA + glycine = N-(9Z,12Z-octadecadienoyl)-glycine + CoA + H(+)

  Catalysed by SLC26A4, SLC6A9, SLC6A14, GLYATL2extracellular space, cytosol

• acetaldehydeReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. Transport of L-Threonine by Atb0 Transporter
  3. L-threonine acetaldehyde-lyase (glycine-forming)

  Catalysed by SLC26A4, SLC6A14extracellular space, cytosol

• acetylcholineReach from here →
  1. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)
  2. transport of GSH and triiodothyronine (cytosol to extracellular)
  3. transport of acetylcholine and GSH (cytosol to extracellular)

  Catalysed by DIO1, DIO3, DIO2, SLCO1A2 and 1 morecytosol, extracellular spaceOne of 7 routes

• pyruvateReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of chloride and formate (cytosol to extracellular)
  3. transport of formate and pyruvate (cytosol to extracellular)

  Catalysed by SLC26A4, SLC16A4, SLC16A5, SLC16A7 and 2 moreextracellular space, cytosolOne of 18 routes

• all-trans-retinoic acidReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of chloride and formate (cytosol to extracellular)
  3. transport of formate and retinoate (cytosol to extracellular)

  Catalysed by SLC26A4, SLC16A4, SLC16A5extracellular space, cytosolOne of 2 routes

• 4a-hydroxytetrahydrobiopterinReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. Transport of L-Phenylalanine by Atb0 Transporter
  3. L-phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase(4-hydroxylating)

  Catalysed by SLC26A4, SLC6A14, PAHextracellular space, cytosolOne of 3 routes

• CHEBI:15477Reach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. 2-Methylbutyrylglycine Transport, Extracellular
  3. glycine N-acyltransferase (2-methylbutyryl-CoA)

  Catalysed by SLC26A4, SLC6A5, GLYAT, GLYATL2 and 1 moreextracellular space, cytosol, mitochondrial matrix

• propionyl-CoAReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. Carnitine Transport by Atb0
  3. Active Transport

  Catalysed by SLC26A4, SLC6A14extracellular space, cytosol, mitochondrial matrixOne of 2 routes

• CHEBI:15570Reach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. transport of D-alanine and glycine (cytosol to extracellular)

  Catalysed by SLC26A4, SLC6A9, SLC6A14, SLC3A2 and 1 moreextracellular space, cytosolOne of 5 routes

• (S)-malateReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of malate and sulfate (cytosol to mitochondria)

  Catalysed by SLC26A4, SLC26A6, SLC25A10extracellular space, cytosol, mitochondrial matrixOne of 4 routes

• CHEBI:15611Reach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. S-Adenosyl-L-methionine:glycine N-methyltransferase

  Catalysed by SLC26A4, SLC6A9, SLC6A14, GNMTextracellular space, cytosol

• 10-formyltetrahydrofolic acidReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of chloride and formate (cytosol to extracellular)
  3. Formate:tetrahydrofolate ligase (ADP-forming)

  Catalysed by SLC26A4, MTHFD1extracellular space, cytosolOne of 2 routes

• (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterinReach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. Transport of L-Phenylalanine by Atb0 Transporter
  3. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine

  Catalysed by SLC26A4, SLC6A14, PAHextracellular space, cytosolOne of 2 routes

• CHEBI:15650Reach from here →
  1. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)
  2. transport of GSH and triiodothyronine (cytosol to extracellular)
  3. transport of GSH and leukotriene E4 (cytosol to extracellular)

  Catalysed by DIO1, DIO3, DIO2, SLCO1A2 and 2 morecytosol, extracellular spaceOne of 4 routes

• CHEBI:15699Reach from here →
  1. transport of chloride and iodide (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. transport of glycine and homoserine (cytosol to extracellular)

  Catalysed by SLC26A4, SLC6A9, SLC6A14, SLC7A5extracellular space, cytosolOne of 52 routes

• betaine aldehydeReach from here →
  1. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)
  2. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine + AH2
  3. choline + A = betaine aldehyde + AH2

  Catalysed by DIO1, DIO3, DIO2, CHDHcytosolOne of 4 routes