CHEBI:15746

Three steps

• a cholesterol esterReach from here →
  1. diamine N-acetyltransferase (N1-acetylspermine)
  2. acyl-CoA:sphingosine N-acyltransferase
  3. an acyl-CoA + cholesterol = a cholesterol ester + CoA

  Catalysed by SAT1, SAT2, ASAH1, ACER2 and 4 morecytosol, Golgi apparatus

• taurolithocholateReach from here →
  1. diamine N-acetyltransferase (N1-acetylspermine)
  2. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)
  3. bile acid-CoA:amino acid N-acyltransferase (lithocholate)

  Catalysed by SAT1, SAT2, BAATcytosolOne of 2 routes

• L-isoleucineReach from here →
  1. diamine N-acetyltransferase (N1-acetylspermine)
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. transport of glycine and isoleucine (cytosol to extracellular)

  Catalysed by SAT1, SAT2, GLYAT, GLYATL2 and 2 morecytosol, mitochondrial matrix, extracellular spaceOne of 18 routes

• CHEBI:17203Reach from here →
  1. diamine N-acetyltransferase (N1-acetylspermine)
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. transport of glycine and proline (cytosol to extracellular)

  Catalysed by SAT1, SAT2, GLYAT, GLYATL2 and 3 morecytosol, mitochondrial matrix, extracellular spaceOne of 15 routes

• S-(4,8-dimethylnonanoyl)-4'-phosphopantetheineReach from here →
  1. diamine N-acetyltransferase (N1-acetylspermine)
  2. Carnitine Dimethyl Nonanoyl Transferase, Revsible, Peroxisomal
  3. 4,8-dimethylnonanoyl-CoA + H2O = S-(4,8-dimethylnonanoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)

  Catalysed by SAT1, SAT2, CRAT, CROT and 1 morecytosol, peroxisome

• S-(9Z,12Z,15Z-octadecatrienoyl)-4'-phosphopantetheineReach from here →
  1. diamine N-acetyltransferase (N1-acetylspermine)
  2. long-chain-fatty-acid-CoA ligase (linolenate)
  3. (9Z,12Z,15Z)-octadecatrienoyl-CoA + H2O = S-(9Z,12Z,15Z-octadecatrienoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)

  Catalysed by SAT1, SAT2, SLC27A2, ACSL4 and 7 morecytosol

• S-(9Z,12Z-octadecadienoyl)-4'-phosphopantetheineReach from here →
  1. diamine N-acetyltransferase (N1-acetylspermine)
  2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)
  3. (9Z,12Z)-octadecadienoyl-CoA + H2O = S-(9Z,12Z-octadecadienoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)

  Catalysed by SAT1, SAT2, SLC27A2, ACSL4 and 7 morecytosol

• S-(9Z-hexadecenoyl)-4'-phosphopantetheineReach from here →
  1. diamine N-acetyltransferase (N1-acetylspermine)
  2. long-chain-fatty-acid-CoA ligase (palmitolate)
  3. (9Z)-hexadecenoyl-CoA + H2O = S-(9Z-hexadecenoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)

  Catalysed by SAT1, SAT2, SLC27A2, ACSL4 and 7 morecytosol

• itaconateReach from here →
  1. diamine N-acetyltransferase (N1-acetylspermine)
  2. Itaconate:CoA ligase (GDP-forming)
  3. Itaconate:CoA ligase (GDP-forming)

  Catalysed by SAT1, SAT2, SUCLG1, SUCLG2 and 1 morecytosol, mitochondrial matrixOne of 4 routes

• N-octadecanoyl-heptadecasphing-4-enineReach from here →
  1. diamine N-acetyltransferase (N1-acetylspermine)
  2. long-chain-fatty-acid-CoA ligase (stearate)
  3. heptadecasphing-4-enine + octadecanoyl-CoA = N-octadecanoyl-heptadecasphing-4-enine + CoA + H(+)

  Catalysed by SAT1, SAT2, SLC27A2, ACSL4 and 6 morecytosol

• all-trans-retinolReach from here →
  1. diamine N-acetyltransferase (N1-acetylspermine)
  2. Palmitoyl-CoA:retinol O-acyltransferase
  3. all-trans-Retinol 11-cis-trans-isomerase

  Catalysed by SAT1, SAT2, DGAT1, LRAT and 3 morecytosolOne of 2 routes

• linoleic acidReach from here →
  1. diamine N-acetyltransferase (N1-acetylspermine)
  2. Carnitine O-Palmitoyltransferase
  3. Utilized Transport

  Catalysed by SAT1, SAT2, CPT1A, CPT1C and 1 morecytosol, endoplasmic reticulumOne of 3 routes

• 1-(alk-1-enyl)-2-acyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. diamine N-acetyltransferase (N1-acetylspermine)
  2. acyl-CoA:sphingosine N-acyltransferase
  3. Acyl-CoA:1-alkenylglycerophosphoethanolamine O-acyltransferase

  Catalysed by SAT1, SAT2, ASAH1, ACER2 and 6 morecytosol, Golgi apparatus

• O-hexadecanoyl-(R)-carnitineReach from here →
  1. diamine N-acetyltransferase (N1-acetylspermine)
  2. Carnitine O-Palmitoyltransferase
  3. palmitoyl-CoA:L-carnitine O-palmitoyltransferase

  Catalysed by SAT1, SAT2, CPT1A, CPT1C and 2 morecytosol, peroxisomeOne of 14 routes

• AH2Reach from here →
  1. diamine N-acetyltransferase (N1-acetylspermine)
  2. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)
  3. uridine(34) in tRNA + 5,10-methylenetetrahydrofolate + taurine + GTP + A + H2O = 5-taurinomethyluridine(34) in tRNA + 7,8-dihydrofolate + GDP + AH2 + phosphate + H(+)

  Catalysed by SAT1, SAT2, BAAT, MTO1cytosolOne of 6 routes

• 1-O-acyl-sn-glycero-3-phosphocholine(1+)Reach from here →
  1. diamine N-acetyltransferase (N1-acetylspermine)
  2. Palmitoyl-CoA:retinol O-acyltransferase
  3. Lecithin Retinol Acyltransferase (11-Cis)

  Catalysed by SAT1, SAT2, DGAT1, LRAT and 3 morecytosol

• 5-aminolevulinic acidReach from here →
  1. diamine N-acetyltransferase (N1-acetylspermine)
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. succinyl-CoA:glycine C-succinyltransferase (decarboxylating)

  Catalysed by SAT1, SAT2, GLYAT, GLYATL2 and 4 morecytosol, mitochondrial matrixOne of 2 routes

• all-trans-retinyl hexadecanoateReach from here →
  1. diamine N-acetyltransferase (N1-acetylspermine)
  2. Palmitoyl-CoA:retinol O-acyltransferase
  3. all-trans-retinyl hexadecanoate + H2O = 11-cis-retinol + hexadecanoate + H(+)

  Catalysed by SAT1, SAT2, DGAT1, LRAT and 4 morecytosol

• Ala-tRNA(Ala)Reach from here →
  1. diamine N-acetyltransferase (N1-acetylspermine)
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. L-Alanine:tRNA(Ala) ligase (AMP-forming)

  Catalysed by SAT1, SAT2, AARS1cytosol, mitochondrial matrix

• a 1,2-diacyl-sn-glycerolReach from here →
  1. diamine N-acetyltransferase (N1-acetylspermine)
  2. acyl-CoA:sphingosine N-acyltransferase
  3. a 2-acylglycerol + an acyl-CoA = a 1,2-diacyl-sn-glycerol + CoA

  Catalysed by SAT1, SAT2, ASAH1, ACER2 and 5 morecytosol, Golgi apparatus

• a triacylglycerolReach from here →
  1. diamine N-acetyltransferase (N1-acetylspermine)
  2. acyl-CoA:sphingosine N-acyltransferase
  3. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase

  Catalysed by SAT1, SAT2, ASAH1, ACER2 and 7 morecytosol, Golgi apparatus

• CHEBI:17895Reach from here →
  1. diamine N-acetyltransferase (N1-acetylspermine)
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. transport of glycine and tyrosine (cytosol to extracellular)

  Catalysed by SAT1, SAT2, GLYAT, GLYATL2 and 2 morecytosol, mitochondrial matrix, extracellular spaceOne of 19 routes

• 3-oxopropanoic acidReach from here →
  1. spermidine:oxygen oxidoreductase (spermidine-forming)
  2. Beta-Aminopropion Aldehyde:NAD+ Oxidoreductase, Mitochondrial
  3. beta-alanine:2-oxoglutarate aminotransferase

  Catalysed by SMOX, ALDH2, ALDH1B1, ABATcytosol, mitochondrial matrix

• butanoateReach from here →
  1. diamine N-acetyltransferase (N1-acetylspermine)
  2. Butanoate:CoA ligase (AMP-forming)
  3. butanoyl-CoA + H2O = butanoate + CoA + H(+)

  Catalysed by SAT1, SAT2, ACSM4, ACSM1 and 10 morecytosol

• CHEBI:18019Reach from here →
  1. spermidine:oxygen oxidoreductase (spermidine-forming)
  2. deoxyhypusine synthase (1,3-diaminopropane)
  3. deoxyhypusine synthase (1,3-diaminopropane)

  Catalysed by SMOX, DHPScytosolOne of 11 routes

• L-glutamineReach from here →
  1. diamine N-acetyltransferase (N1-acetylspermine)
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. transport of glutamine and glycine (cytosol to extracellular)

  Catalysed by SAT1, SAT2, GLYAT, GLYATL2 and 2 morecytosol, mitochondrial matrix, extracellular spaceOne of 29 routes

• CHEBI:18095Reach from here →
  1. diamine N-acetyltransferase (N1-acetylspermine)
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. Transport of Hydroxy-Proline

  Catalysed by SAT1, SAT2, SLC1A4cytosol, mitochondrial matrix, extracellular space

• O-octanoyl-(R)-carnitineReach from here →
  1. diamine N-acetyltransferase (N1-acetylspermine)
  2. Carnitine O-Palmitoyltransferase
  3. solute carrier (L-carnitine)

  Catalysed by SAT1, SAT2, CPT1A, CPT1C and 2 morecytosol, mitochondrial matrixOne of 11 routes

• CHEBI:18132Reach from here →
  1. diamine N-acetyltransferase (N1-acetylspermine)
  2. Acetyl-CoA:choline O-acetyltransferase
  3. ATP:choline phosphotransferase

  Catalysed by SAT1, SAT2, CHAT, CHKA and 1 morecytosol, nucleus

• dodecanoateReach from here →
  1. diamine N-acetyltransferase (N1-acetylspermine)
  2. long-chain-fatty-acid-CoA ligase (lauric acid)
  3. Lauroyl-CoA hydrolase

  Catalysed by SAT1, SAT2, SLC27A2, ACSL4 and 10 morecytosolOne of 2 routes

• N(1)-(5-phospho-D-ribosyl)glycinamideReach from here →
  1. diamine N-acetyltransferase (N1-acetylspermine)
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. 5-Phospho-D-ribosylamine:glycine ligase (ADP-forming)

  Catalysed by SAT1, SAT2, GLYAT, GLYATL2 and 2 morecytosol, mitochondrial matrix

• (2E,5Z,8Z,11Z,14Z,17Z)-eicosahexaenoyl-CoAReach from here →
  1. diamine N-acetyltransferase (N1-acetylspermine)
  2. long-chain-fatty-acid-CoA ligase (EPA)
  3. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + O2 = (2E,5Z,8Z,11Z,14Z,17Z)-eicosahexaenoyl-CoA + H2O2

  Catalysed by SAT1, SAT2, SLC27A2, ACSL4 and 7 morecytosol

• 1-octadecanoyl-2-acyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. diamine N-acetyltransferase (N1-acetylspermine)
  2. long-chain-fatty-acid-CoA ligase (stearate)
  3. a 2-acyl-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA = 1-octadecanoyl-2-acyl-sn-glycero-3-phosphoethanolamine + CoA

  Catalysed by SAT1, SAT2, SLC27A2, ACSL4 and 6 morecytosol

• ophthalmateReach from here →
  1. diamine N-acetyltransferase (N1-acetylspermine)
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. gamma-L-glutamyl-(2S)-2-aminobutanoate + glycine + ATP = ophthalmate + ADP + phosphate + H(+)

  Catalysed by SAT1, SAT2, GLYAT, GLYATL2 and 2 morecytosol, mitochondrial matrix

• S-methylmercury-L-cysteineReach from here →
  1. diamine N-acetyltransferase (N1-acetylspermine)
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)

  Catalysed by SAT1, SAT2, NAGS, SLC7A8cytosol, mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• 2-aminoisobutanoateReach from here →
  1. diamine N-acetyltransferase (N1-acetylspermine)
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. 2-aminoisobutanoate(out) + L-alanine(in) = 2-aminoisobutanoate(in) + L-alanine(out)

  Catalysed by SAT1, SAT2, SLC7A10cytosol, mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• 11-cis-retinyl esterReach from here →
  1. diamine N-acetyltransferase (N1-acetylspermine)
  2. Palmitoyl-CoA:retinol O-acyltransferase
  3. 11-cis-retinol + a fatty acyl-CoA = 11-cis-retinyl ester + CoA

  Catalysed by SAT1, SAT2, DGAT1, LRAT and 3 morecytosol

• 5-(3,3-dimethylguanidino)-2-oxopentanoateReach from here →
  1. diamine N-acetyltransferase (N1-acetylspermine)
  2. ATP citrate lyase (citrate)
  3. N(omega),N(omega)-dimethyl-L-arginine + oxaloacetate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-aspartate

  Catalysed by SAT1, SAT2, ACLY, AGXT2cytosol

• N(omega),N('omega)-dimethyl-L-arginineReach from here →
  1. diamine N-acetyltransferase (N1-acetylspermine)
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine

  Catalysed by SAT1, SAT2, GLYAT, GLYATL2 and 2 morecytosol, mitochondrial matrixOne of 2 routes

• 1-butanoyl-2-(9Z-octadecenoyl)-glycerolReach from here →
  1. diamine N-acetyltransferase (N1-acetylspermine)
  2. Butanoate:CoA ligase (AMP-forming)
  3. 2-(9Z-octadecenoyl)-glycerol + butanoyl-CoA = 1-butanoyl-2-(9Z-octadecenoyl)-glycerol + CoA

  Catalysed by SAT1, SAT2, ACSM4, ACSM1 and 6 morecytosol

• 1-octanoyl-2-(9Z-octadecenoyl)-glycerolReach from here →
  1. diamine N-acetyltransferase (N1-acetylspermine)
  2. Octanoyl-CoA:L-carnitine O-octanoyltransferase
  3. 2-(9Z-octadecenoyl)-glycerol + octanoyl-CoA = 1-octanoyl-2-(9Z-octadecenoyl)-glycerol + CoA

  Catalysed by SAT1, SAT2, CROT, MOGAT2 and 1 morecytosol, mitochondrial matrix

• 1-eicosanoyl-2-(9Z-octadecenoyl)-glycerolReach from here →
  1. diamine N-acetyltransferase (N1-acetylspermine)
  2. long-chain-fatty-acid-CoA ligase (eicosanoate)
  3. eicosanoyl-CoA + 2-(9Z-octadecenoyl)-glycerol = 1-eicosanoyl-2-(9Z-octadecenoyl)-glycerol + CoA

  Catalysed by SAT1, SAT2, SLC27A2, ACSL4 and 8 morecytosol

• 5,6,7,8-tetrahydrofolic acidReach from here →
  1. diamine N-acetyltransferase (N1-acetylspermine)
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase

  Catalysed by SAT1, SAT2, GLYAT, GLYATL2 and 2 morecytosol, mitochondrial matrixOne of 2 routes

• O-butanoyl-(R)-carnitineReach from here →
  1. diamine N-acetyltransferase (N1-acetylspermine)
  2. Butanoate:CoA ligase (AMP-forming)
  3. butanoyl-CoA + (R)-carnitine = O-butanoyl-(R)-carnitine + CoA

  Catalysed by SAT1, SAT2, ACSM4, ACSM1 and 5 morecytosol

• S-disulfanyl-L-cysteineReach from here →
  1. diamine N-acetyltransferase (N1-acetylspermine)
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. S-sulfanyl-L-cysteine + L-cysteine = S-disulfanyl-L-cysteine + L-alanine

  Catalysed by SAT1, SAT2, NAGS, CARS2cytosol, mitochondrial matrix

• 3-oxo-(9Z)-eicosenoyl-CoAReach from here →
  1. diamine N-acetyltransferase (N1-acetylspermine)
  2. carnitine O-palmitoyltransferase ((7Z)-octadecenoyl-CoA)
  3. very-long-chain 3-oxoacyl-CoA synthase ((7Z)-octadecenoyl-CoA)

  Catalysed by SAT1, SAT2, CPT1A, CPT1C and 8 morecytosol

• (2E,6Z,9Z,12Z)-octadecatetraenoyl-CoAReach from here →
  1. diamine N-acetyltransferase (N1-acetylspermine)
  2. long-chain-fatty-acid-CoA ligase (gamma-linolenate)
  3. (6Z,9Z,12Z)-octadecatrienoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E,6Z,9Z,12Z)-octadecatetraenoyl-CoA + reduced [electron-transfer flavoprotein]

  Catalysed by SAT1, SAT2, SLC27A2, ACSL4 and 9 morecytosolOne of 2 routes

• (2E,7Z,10Z)-hexadecatrienoyl-CoAReach from here →
  1. diamine N-acetyltransferase (N1-acetylspermine)
  2. Fatty Acid Beta Oxidation Trans (C18:2->C16:2), Mitochondrial
  3. (7Z,10Z)-hexadecadienoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E,7Z,10Z)-hexadecatrienoyl-CoA + reduced [electron-transfer flavoprotein]

  Catalysed by SAT1, SAT2, HADHA, ACADVL and 3 morecytosol, mitochondrial matrix

• (2E,4Z,7Z,10Z,13Z)-hexadecapentaenoyl-CoAReach from here →
  1. diamine N-acetyltransferase (N1-acetylspermine)
  2. Fatty Acid Beta Oxidation (C18:4->C16:4), Mitochondrial
  3. Fatty Acid Beta Oxidation (C16:4->C16:5), Mitochondrial

  Catalysed by SAT1, SAT2, HADHA, ACADVL and 1 morecytosol, mitochondrial matrixOne of 4 routes

• (2E,7Z,10Z,13Z)-hexadecatetraenoyl-CoAReach from here →
  1. diamine N-acetyltransferase (N1-acetylspermine)
  2. Fatty Acid Beta Oxidation (C18:3->C16:3), Mitochondrial
  3. (7Z,10Z,13Z)-hexadecatrienoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E,7Z,10Z,13Z)-hexadecatetraenoyl-CoA + reduced [electron-transfer flavoprotein]

  Catalysed by SAT1, SAT2, HADHA, ACADVL and 3 morecytosol, mitochondrial matrix