arachidonoyl-CoA

Two steps

• 1,2-diacyl-sn-glycero-3-phosphocholine(1+)Reach from here →
  1. acyl-CoA pool formation and breakdown
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase

  Catalysed by LPCAT4, LPCAT3, LPCAT2, LPCAT1cytosol

• 11-cis-retinolReach from here →
  1. Arachidonyl-CoA hydrolase
  2. Palmitoyl-CoA:retinol O-acyltransferase

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 6 morecytosol

• phosphatidic acidReach from here →
  1. acyl-CoA pool formation and breakdown
  2. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 5 morecytosol, mitochondrial matrixOne of 7 routes

• oxaloacetateReach from here →
  1. Arachidonyl-CoA hydrolase
  2. ATP citrate lyase (citrate)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 2 morecytosol

• CHEBI:16856Reach from here →
  1. Arachidonyl-CoA hydrolase
  2. transport of arachidonate and GSH (cytosol to extracellular)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 1 morecytosol, extracellular spaceOne of 2 routes

• 1-acyl-sn-glycerol 3-phosphateReach from here →
  1. glycerol-3-phosphate 1-O-acyltransferase (arachidonyl-CoA)
  2. 1-acylglycerol-3P-LD-TG1 pool (liver tissue) formation

  Catalysed by GPAT3, GPAT2, GPAT4, GPAMcytosolOne of 9 routes

• a cholesterol esterReach from here →
  1. acyl-CoA pool formation and breakdown
  2. an acyl-CoA + cholesterol = a cholesterol ester + CoA

  Catalysed by SOAT2, SOAT1cytosol

• anilineReach from here →
  1. Arachidonyl-CoA hydrolase
  2. Acetyl-CoA:arylamine N-acetyltransferase

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 3 morecytosol

• CHEBI:17312Reach from here →
  1. Arachidonyl-CoA hydrolase
  2. N1,N12-diacetylspermine to N1-acetylspermine conversion

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 1 morecytosolOne of 2 routes

• 1-(alk-1-enyl)-2-acyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. acyl-CoA pool formation and breakdown
  2. Acyl-CoA:1-alkenylglycerophosphoethanolamine O-acyltransferase

  Catalysed by LPCAT4, LPCAT3, LPCAT2, LPCAT1cytosol

• L-cysteineReach from here →
  1. Arachidonyl-CoA hydrolase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 2 morecytosol, mitochondrial matrix

• (7Z,10Z,13Z)-hexadecatrienoyl-CoAReach from here →
  1. Arachidonyl-CoA hydrolase
  2. Fatty Acid Beta Oxidation (C18:3->C16:3), Mitochondrial

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 4 morecytosol, mitochondrial matrix

• a 1,2-diacyl-sn-glycerolReach from here →
  1. acyl-CoA pool formation and breakdown
  2. a 2-acylglycerol + an acyl-CoA = a 1,2-diacyl-sn-glycerol + CoA

  Catalysed by MOGAT2, AWAT2, MOGAT1cytosol

• a triacylglycerolReach from here →
  1. acyl-CoA pool formation and breakdown
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase

  Catalysed by DGAT1, MOGAT2, MOGAT3, MOGAT1 and 1 morecytosol

• CHEBI:17927Reach from here →
  1. Arachidonyl-CoA hydrolase
  2. N1,N8-diacetylspermidine to N1-acetylspermidine conversion

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 1 morecytosol

• (5Z)-dodecenoyl-CoAReach from here →
  1. Arachidonyl-CoA hydrolase
  2. acetyl-CoA C-acyltransferase (3-oxomyrist-7-enoyl-CoA)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 4 morecytosol, mitochondrial matrixOne of 2 routes

• O-[(5Z),(8Z),(11Z),(14Z)-eicosatetraenoyl]-beta-D-glucuronateReach from here →
  1. Arachidonyl-CoA hydrolase
  2. (5Z,8Z,11Z,14Z)-eicosatetraenoate + UDP-alpha-D-glucuronate = O-[(5Z),(8Z),(11Z),(14Z)-eicosatetraenoyl]-beta-D-glucuronate + UDP

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 7 morecytosol

• (11Z)-docosenoyl-CoA(4-)Reach from here →
  1. Arachidonyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (cis-cetoleic acid)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 9 morecytosolOne of 6 routes

• (7Z)-tetradecenoyl-CoAReach from here →
  1. Arachidonyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase ((7Z)-tetradecenoic acid)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 9 morecytosolOne of 9 routes

• (4Z,7Z,10Z,13Z)-hexadecatetraenoyl-CoAReach from here →
  1. Arachidonyl-CoA hydrolase
  2. Fatty Acid Beta Oxidation (C18:4->C16:4), Mitochondrial

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 4 morecytosol, mitochondrial matrixOne of 3 routes

• (7Z,10Z)-hexadecadienoyl-CoAReach from here →
  1. Arachidonyl-CoA hydrolase
  2. Fatty Acid Beta Oxidation Trans (C18:2->C16:2), Mitochondrial

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 4 morecytosol, mitochondrial matrix

• (4Z,7Z)-decadienoyl-CoAReach from here →
  1. Arachidonyl-CoA hydrolase
  2. Fatty Acid Beta Oxidation (C12:3->C10:2), Mitochondrial

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 4 morecytosol, mitochondrial matrixOne of 2 routes

• (5Z)-octenoyl-CoAReach from here →
  1. Arachidonyl-CoA hydrolase
  2. Fatty Acid Beta Oxidation (C10:2->C8:1), Mitochondrial

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 4 morecytosol, mitochondrial matrixOne of 2 routes

• N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamineReach from here →
  1. Arachidonyl-CoA hydrolase
  2. fatty acylamide amidohydrolase

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 2 morecytosol

• CHEBI:27540Reach from here →
  1. Arachidonyl-CoA hydrolase
  2. medium-chain acyl-CoA ligase (hexanoic acid)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 7 morecytosolOne of 6 routes

• elaidic acidReach from here →
  1. Arachidonyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (elaidate)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 9 morecytosolOne of 6 routes

• CHEBI:28701Reach from here →
  1. Arachidonyl-CoA hydrolase
  2. Propanoyl-CoA:acetyl-CoA C-acyltransferase

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 4 morecytosol, peroxisomeOne of 7 routes

• an N-acylsphinganineReach from here →
  1. acyl-CoA pool formation and breakdown
  2. sphingosine N-acyltransferase (sphinganine)

  Catalysed by CERS1, CERS6, CERS3, CERS5 and 2 morecytosol

• 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerolReach from here →
  1. glycerol-3-phosphate 1-O-acyltransferase (arachidonyl-CoA)
  2. 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + phosphate

  Catalysed by GPAT3, GPAT2, GPAT4, GPAM and 1 morecytosol

• fatty acidReach from here →
  1. Arachidonyl-CoA hydrolase
  2. (10Z)-heptadecenoic acid formation

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 1 morecytosolOne of 4 routes

• a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholineReach from here →
  1. acyl-CoA pool formation and breakdown
  2. Acyl-CoA:1-alkyl-sn-glycero-3-phosphocholine O-acyltransferase

  Catalysed by LPCAT4, LPCAT3, LPCAT2, LPCAT1cytosol

• a 1,3-diacylglycerolReach from here →
  1. acyl-CoA pool formation and breakdown
  2. a 1-acylglycerol + an acyl-CoA = a 1,3-diacylglycerol + CoA

  Catalysed by MOGAT2, MOGAT1cytosol

• a 1,2-diacylglycerolReach from here →
  1. acyl-CoA pool formation and breakdown
  2. a 2-acylglycerol + an acyl-CoA = a 1,2-diacylglycerol + CoA

  Catalysed by MOGAT2, MOGAT3, LPGAT1, TMEM68 and 1 morecytosolOne of 2 routes

• taurineReach from here →
  1. Arachidonyl-CoA hydrolase
  2. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 1 morecytosolOne of 2 routes

• 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerolReach from here →
  1. Arachidonyl-CoA hydrolase
  2. fatty acid amide hydrolase (2-arachidonoylglycerol)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 2 morecytosol

• a 1,2-diacyl-sn-glycero-3-phospho-L-serineReach from here →
  1. acyl-CoA pool formation and breakdown
  2. a 1-acyl-sn-glycero-3-phospho-L-serine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CoA

  Catalysed by LPCAT4, LPCAT3, MBOAT1cytosol

• glycineReach from here →
  1. Arachidonyl-CoA hydrolase
  2. glycine N-acyltransferase (N-arachidonoylglycine)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 4 morecytosol, mitochondrial matrixOne of 10 routes

• (R)-methylmalonyl-CoAReach from here →
  1. Arachidonyl-CoA hydrolase
  2. aldehyde dehydrogenase (2-methyl-3-oxopropanoate)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 2 morecytosol, mitochondrial matrixOne of 2 routes

• (S)-methylmalonyl-CoAReach from here →
  1. Arachidonyl-CoA hydrolase
  2. (S)-methylmalonyl-CoA hydrolase

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 1 morecytosol, mitochondrial matrix

• 3'-dephospho-CoAReach from here →
  1. Arachidonyl-CoA hydrolase
  2. acid phosphatase 2, lysosomal (CoA)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 2 morecytosol, lysosomeOne of 2 routes

• (2E)-dodecenoyl-CoAReach from here →
  1. Arachidonyl-CoA hydrolase
  2. (2E)-dodecenoyl-CoA formation

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 1 morecytosol, mitochondrial matrixOne of 3 routes

• 4,8,12-trimethyltridecanoyl-CoAReach from here →
  1. Arachidonyl-CoA hydrolase
  2. propanoyl-CoA C-acyltransferase (3-ketopristanoyl-CoA)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 3 morecytosol, peroxisomeOne of 2 routes

• (6Z,9Z,12Z)-octadecatrienoyl-CoAReach from here →
  1. Arachidonyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (gamma-linolenate)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 9 morecytosolOne of 8 routes

• (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoAReach from here →
  1. Arachidonyl-CoA hydrolase
  2. (5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 12 morecytosol

• butanoyl-CoAReach from here →
  1. Arachidonyl-CoA hydrolase
  2. Butanoate:CoA ligase (AMP-forming)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 7 morecytosolOne of 9 routes

• dodecanoyl-CoAReach from here →
  1. Arachidonyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (lauric acid)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 9 morecytosolOne of 10 routes

• glutaryl-CoAReach from here →
  1. Arachidonyl-CoA hydrolase
  2. Production of Glutaryl Carnitine

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 4 morecytosolOne of 2 routes

• eicosanoyl-CoAReach from here →
  1. Arachidonyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (eicosanoate)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 9 morecytosolOne of 13 routes

• itaconyl-CoAReach from here →
  1. Arachidonyl-CoA hydrolase
  2. Itaconate:CoA ligase (GDP-forming)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 4 morecytosol, mitochondrial matrixOne of 2 routes

• (9Z,12Z)-octadecadienoyl-CoAReach from here →
  1. Arachidonyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 9 morecytosolOne of 14 routes