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Proteins/UNIPROT:P05023
Catalytic subunit of the Na(+)/K(+)-ATPase pump that hydrolyzes ATP to exchange ions across the plasma membrane, exporting 3 Na(+) and importing 2 K(+) per cycle against electrochemical gradients. It undergoes ATP-driven conformational changes that allow alternating binding and release of Na(+) and K(+) ions across the membrane. This process maintains essential Na(+) and K(+) gradients for membrane potential and cellular function. Could also be part of an osmosensory signaling pathway that senses body-fluid sodium levels and controls salt intake behavior as well as voluntary water intake to regulate sodium homeostasis (By similarity)..
Function from UniProtKB (P05023), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 2 · transported by
2 compounds
2 compounds.
0 reported routes2 assembled routes
3 rows
289 statements
289 statements · 9 reference databases · Subject: ATP1A1 · Sources: Bgee, gene ontology, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
2 reactions
ATP+water+2potassium atom+3sodium(1+)ADP+proton+2potassium atom+3sodium(1+)+phosphate(3-)
Transported by ATP1A1 & FXYD2 & ATP1B4 or ATP1B2 & ATP1A2 & FXYD2 or ATP1A2 & ATP1B3 &
2 names
Resolves to: ATP1A1
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR05429CC BY 4.0Reference data
2K(+)+3sodium(1+)+ATP(4-)+water2K(+)+3sodium(1+)+ADP(3-)+hydrogenphosphate+hydron
Transported by ATP1A1 or ATP1A3 or ATP1A2 or ATP12A or ATP1A4
Reaction pageLeft to rightBalanced
Rhea RHEA:18353CC BY 4.0Reference data