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Proteins/UNIPROT:P60604
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Involved in endoplasmic reticulum-associated degradation (ERAD). Required for sterol-induced ubiquitination of 3-hydroxy-3-methylglutaryl coenzyme A reductase and its subsequent proteasomal degradation..
Function from UniProtKB (P60604), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
57 statements
57 statements · 4 reference databases · Subject: UBE2G2 · Sources: gene ontology, Hetionet, Reactome, WikiPathways
1 reaction
4 names
Resolves to: UBE2G2
Reaction pageLeft to rightBalance undeterminableEC 2.3.2.23, 2.3.2.27, 6.2.1.45cytosol
Human-GEM MAR09491CC BY 4.0Reference data