Pathway
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
In the nucleus, SMAD2/3:SMAD4 heterotrimer complex acts as a transcriptional regulator. The activity of SMAD2/3 complex is regulated both positively and negatively by association with other transcription factors. In addition, the activity of SMAD2/3:SMAD4 complex can be inhibited by nuclear protein phosphatases and ubiquitin ligases.
REACT:R-HSA-2173793Reactome
What the reference databases state
Statements
50 statements
50 statements · 1 reference database · Subject: Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer · Sources: Reactome
- ATP1B4 participates in Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimerProteinReactome R-HSA-2173793Inferred only
- CCNC participates in Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimerProteinReactome R-HSA-2173793Inferred only
- CCNK participates in Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimerProteinReactome R-HSA-2173793Inferred only
- CCNT1 participates in Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimerProteinReactome R-HSA-2173793Inferred only
- CCNT2 participates in Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimerProteinReactome R-HSA-2173793Inferred only
- CDK8 participates in Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimerProteinReactome R-HSA-2173793Inferred only
- CDK9 participates in Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimerProteinReactome R-HSA-2173793Inferred only
- CDKN2B participates in Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimerProteinReactome R-HSA-2173793Inferred only
- COL1A2 participates in Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimerProteinReactome R-HSA-2173793Inferred only
- E2F4 participates in Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimerProteinReactome R-HSA-2173793Inferred only
- E2F5 participates in Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimerProteinReactome R-HSA-2173793Inferred only
- EP300 participates in Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimerProteinReactome R-HSA-2173793Inferred only
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- FURIN participates in Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimerProteinReactome R-HSA-2173793Inferred only
- HDAC1 participates in Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimerProteinReactome R-HSA-2173793Inferred only
- JUNB participates in Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimerProteinReactome R-HSA-2173793Inferred only
- MAPK1 participates in Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimerProteinReactome R-HSA-2173793Inferred only
- MAPK3 participates in Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimerProteinReactome R-HSA-2173793Inferred only
- MEN1 participates in Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimerProteinReactome R-HSA-2173793Inferred only
- MYC participates in Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimerProteinReactome R-HSA-2173793Inferred only
- NCOR1 participates in Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimerProteinReactome R-HSA-2173793Inferred only
- NCOR2 participates in Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimerProteinReactome R-HSA-2173793Inferred only
- NEDD4L participates in Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimerProteinReactome R-HSA-2173793Inferred only
- PARP1 participates in Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimerProteinReactome R-HSA-2173793Inferred only
- PPM1A participates in Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimerProteinReactome R-HSA-2173793Inferred only
- RBL1 participates in Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimerProteinReactome R-HSA-2173793Inferred only
- RNF111 participates in Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimerProteinReactome R-HSA-2173793Inferred only
- RPS27A participates in Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimerProteinReactome R-HSA-2173793Inferred only
- SERPINE1 participates in Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimerProteinReactome R-HSA-2173793Inferred only
- SKI participates in Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimerProteinReactome R-HSA-2173793Inferred only
- SKIL participates in Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimerProteinReactome R-HSA-2173793Inferred only
- SMAD2 participates in Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimerProteinReactome R-HSA-2173793Inferred only
- SMAD3 participates in Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimerProteinReactome R-HSA-2173793Inferred only
- SMAD4 participates in Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimerProteinReactome R-HSA-2173793Inferred only
- SMAD7 participates in Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimerProteinReactome R-HSA-2173793Inferred only
- SMURF2 participates in Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimerProteinReactome R-HSA-2173793Inferred only
- SNW1 participates in Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimerProteinReactome R-HSA-2173793Inferred only
- SP1 participates in Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimerProteinReactome R-HSA-2173793Inferred only
- TFDP1 participates in Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimerProteinReactome R-HSA-2173793Inferred only
- TFDP2 participates in Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimerProteinReactome R-HSA-2173793Inferred only
- TGIF1 participates in Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimerProteinReactome R-HSA-2173793Inferred only
- TGIF2 participates in Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimerProteinReactome R-HSA-2173793Inferred only
- TRIM33 participates in Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimerProteinReactome R-HSA-2173793Inferred only
- UBA52 participates in Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimerProteinReactome R-HSA-2173793Inferred only
- UBB participates in Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimerProteinReactome R-HSA-2173793Inferred only
- UBC participates in Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimerProteinReactome R-HSA-2173793Inferred only
- UBE2D1 participates in Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimerProteinReactome R-HSA-2173793Inferred only
- UBE2D3 participates in Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimerProteinReactome R-HSA-2173793Inferred only
- USP9X participates in Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimerProteinReactome R-HSA-2173793Inferred only
- WWTR1 participates in Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimerProteinReactome R-HSA-2173793Inferred only
- YBX1 participates in Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimerProteinReactome R-HSA-2173793Inferred only