ANK3

Required for the organization of specialized membrane domains by linking the membrane to the cytoskeleton. In neurons, participates in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments. In skeletal muscle, required for the localization of dystrophin (DMD) and beta-dystroglycan (betaDAG1) to costameres (By similarity). In rod photoreceptors, required for the transport of cyclic nucleotide-gated (CNG) channel subunits from the inner segment to the sensory cilium outer segment, which is critical for phototransduction and outer segment morphogenesis. Regulates the activity of the potassium channel KCNA1 in response to dietary Mg(2+) levels, contributing to renal Mg(2+) reabsorption. Promotes intracellular adhesion and junctional conductance in myocytes by stabilizing GJA1/CX43 protein abundance and facilitating the localization of PKP2, GJA1/CX43, and SCN5A/Nav1.5 to cell-cell junctions (By similarity)..

Function from UniProtKB (Q12955), read 2026-09-23. CC BY 4.0.