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Proteins/UNIPROT:Q9BTF0
Catalytic subunit of the THUMPD2-TRM112 methyltransferase complex, that specifically mediates the S-adenosyl-L-methionine-dependent N(2)-methylation of guanosine nucleotides, most probably at position 72 (m2G72), in the U6snRNA of the major spliceosome. This modification in the U6 snRNA affects the constitutive splicing efficiency of introns that have suboptimal splice sites and can impact final mRNA levels..
Function from UniProtKB (Q9BTF0), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
23 statements
23 statements · 2 reference databases · Subject: THUMPD2 · Sources: gene ontology, Hetionet
1 reaction
CHEBI:74269+S-adenosyl-L-methionineCHEBI:74481+S-adenosyl-L-homocysteine+hydron
Catalysed by THUMPD2
Reaction pageLeft to rightBalanced
Rhea RHEA:83423CC BY 4.0Reference data
3 names
Resolves to: THUMPD2