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Proteins/UNIPROT:Q9NP61

ARFGAP3

Protein·UNIPROT:Q9NP61

Open in the graph

GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1), which is essential for COPI vesicle formation and retrograde transport between the Golgi and the endoplasmic reticulum. Hydrolysis of ARF1-bound GTP leads to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes. Promotes the proper assembly of the COPI coat lattice, rather than just acting as a simple curvature-dependent GAP like ARFGAP1..

Function from UniProtKB (Q9NP61), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

27 statements

27 statements · 3 reference databases · Subject: ARFGAP3 · Sources: Hetionet, Reactome, WikiPathways

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APP interacts with ARFGAP3ProteinHetionet hetionet:interacts:26286-351Inferred only
CD14 interacts with ARFGAP3ProteinHetionet hetionet:interacts:26286-929Inferred only
CXCL8 interacts with ARFGAP3ProteinHetionet hetionet:interacts:26286-3576Inferred only
SMAD2 interacts with ARFGAP3ProteinHetionet hetionet:interacts:26286-4087Inferred only
UBC interacts with ARFGAP3ProteinHetionet hetionet:interacts:26286-7316Inferred only
ARFGAP3 participates in Asparagine N-linked glycosylationPathwayReactome R-HSA-446203Inferred only
ARFGAP3 participates in CDC42 GTPase cyclePathwayReactome R-HSA-9013148Inferred only
ARFGAP3 participates in Ciliary landscapePathwayWikiPathways WP4352Inferred only
ARFGAP3 participates in COPI-dependent Golgi-to-ER retrograde trafficPathwayReactome R-HSA-6811434Inferred only
ARFGAP3 participates in COPI-mediated anterograde transportPathwayReactome R-HSA-6807878Inferred only
ARFGAP3 participates in ER to Golgi Anterograde TransportPathwayReactome R-HSA-199977Inferred only
ARFGAP3 participates in Golgi-to-ER retrograde transportPathwayReactome R-HSA-8856688Inferred only

Show the remaining 15

ARFGAP3 participates in Intra-Golgi and retrograde Golgi-to-ER trafficPathwayReactome R-HSA-6811442Inferred only
ARFGAP3 participates in Membrane TraffickingPathwayReactome R-HSA-199991Inferred only
ARFGAP3 participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only
ARFGAP3 participates in Post-translational protein modificationPathwayReactome R-HSA-597592Inferred only
ARFGAP3 participates in RHO GTPase cyclePathwayReactome R-HSA-9012999Inferred only
ARFGAP3 participates in RHOG GTPase cyclePathwayReactome R-HSA-9013408Inferred only
ARFGAP3 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
ARFGAP3 participates in Signaling by Rho GTPasesPathwayReactome R-HSA-194315Inferred only
ARFGAP3 participates in Signaling by Rho GTPases, Miro GTPases and RHOBTB3PathwayReactome R-HSA-9716542Inferred only
ARFGAP3 participates in Transport to the Golgi and subsequent modificationPathwayReactome R-HSA-948021Inferred only
ARFGAP3 participates in Vesicle-mediated transportPathwayReactome R-HSA-5653656Inferred only
ACAA1 decreases the expression of ARFGAP3ProteinHetionet hetionet:regulates:30-26286Inferred only
COPA increases the expression of ARFGAP3ProteinHetionet hetionet:regulates:1314-26286Inferred only
HSPA5 increases the expression of ARFGAP3ProteinHetionet hetionet:regulates:3309-26286Inferred only
STK25 decreases the expression of ARFGAP3ProteinHetionet hetionet:regulates:10494-26286Inferred only

Other names

3 names

Resolves to: ARFGAP3

Also called: ADP-ribosylation factor GTPase-activating protein 3ARF GAP 3ARFGAP1

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