Proteins/UNIPROT:Q8WWN8

ARAP3

ProteinUNIPROT:Q8WWN8

Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Acts on ARF6, RAC1, RHOA and CDC42. Plays a role in the internalization of anthrax toxin..

Function from UniProtKB (Q8WWN8), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

1 row

lymphedema has a germline basis in ARAP3DiseaseGenCC HGNC:24097|MONDO:0019297Inferred only

Statements

24 statements

24 statements · 3 reference databases · Subject: ARAP3 · Sources: gene ontology, Hetionet, Reactome

Order

ARAP3 covaries with HOPXProteinHetionet hetionet:covaries:64411-84525Inferred only
ARAP3 covaries with LZTS2ProteinHetionet hetionet:covaries:64411-84445Inferred only
ARAP3 covaries with MDKProteinHetionet hetionet:covaries:4192-64411Inferred only
SH3KBP1 interacts with ARAP3ProteinHetionet hetionet:interacts:30011-64411Inferred only
UBC interacts with ARAP3ProteinHetionet hetionet:interacts:64411-7316Inferred only
ARAP3 participates in CDC42 GTPase cyclePathwayReactome R-HSA-9013148Inferred only
ARAP3 participates in RAC1 GTPase cyclePathwayReactome R-HSA-9013149Inferred only
ARAP3 participates in RAC3 GTPase cyclePathwayReactome R-HSA-9013423Inferred only
ARAP3 participates in RHO GTPase cyclePathwayReactome R-HSA-9012999Inferred only
ARAP3 participates in RHOA GTPase cyclePathwayReactome R-HSA-8980692Inferred only
ARAP3 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
ARAP3 participates in Signaling by Rho GTPasesPathwayReactome R-HSA-194315Inferred only

Show the remaining 12

ARAP3 participates in Signaling by Rho GTPases, Miro GTPases and RHOBTB3PathwayReactome R-HSA-9716542Inferred only
ARAP3 regulates regulation of actin cytoskeleton organizationBiological processgene ontology Q8WWN8|GO:0032956Inferred only
ALAS1 decreases the expression of ARAP3ProteinHetionet hetionet:regulates:211-64411Inferred only
ALDH18A1 decreases the expression of ARAP3ProteinHetionet hetionet:regulates:5832-64411Inferred only
FUS decreases the expression of ARAP3ProteinHetionet hetionet:regulates:2521-64411Inferred only
GNPDA1 decreases the expression of ARAP3ProteinHetionet hetionet:regulates:10007-64411Inferred only
LASP1 decreases the expression of ARAP3ProteinHetionet hetionet:regulates:3927-64411Inferred only
PFKFB3 increases the expression of ARAP3ProteinHetionet hetionet:regulates:5209-64411Inferred only
PPP4R1 decreases the expression of ARAP3ProteinHetionet hetionet:regulates:9989-64411Inferred only
SMAD2 increases the expression of ARAP3ProteinHetionet hetionet:regulates:4087-64411Inferred only
SRRM1 increases the expression of ARAP3ProteinHetionet hetionet:regulates:10250-64411Inferred only
USP22 increases the expression of ARAP3ProteinHetionet hetionet:regulates:23326-64411Inferred only

Other names

3 names

Resolves to: ARAP3

Also called: Centaurin-delta-3CENTD3Cnt-d3

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